王殿仕, 徐天乐, 李继硕
第四军医大学基础部解剖学教研室,梁qiu锯脑研究中心.陕西,西安 710032；中国科学技术大学生命科学学院神经生物学与生物物理学系.安徽,合肥 230027
Modulation of glycine-activated chloride currents by substance P in rat sacral dorsal commissural neurons
Wang Dianshi, Xu Tianle, Li Jishuo
Department of Anatomy and K. K. Leung Brain Research Center,Fourth Military Medical University.Xi^an 710032,Shaanxi；China
The modulatory effect of substance P (SP) on strychnine-sensitive glycine (Gly) response was examined in neurons acutely dissociated from the rat sacral dorsal commissural nucleus (SDCN) using nystatin perforated patch recording configuration under voltage-clamp conditions. The facilitatory action of SP on I_(Gly) could also be abolished by pretreatment with chelerythrine or KN-62 in different neurons, a finding suggesting that protein kinase C (PKC) or Ca~(2+)/calmodulin-dependent protein kinase II (CaMKII) possibly contributes to an intracellular pathway of SP in the augmentation of I_(Gly). The results imply that SP may suppress nociception in the spinal cord by potentiating Gly response.
王殿仕, 徐天乐, 李继硕. P物质对大鼠骶髓后连合核神经元甘氨酸激活的氯电流的调控[J]. 生理学报 1999; 51 (4): .
Wang Dianshi, Xu Tianle, Li Jishuo. Modulation of glycine-activated chloride currents by substance P in rat sacral dorsal commissural neurons. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).