李博文, 勾萌, 肖蓉*, 李庆伟*
辽宁师范大学生命科学学院 七鳃鳗研究中心，辽宁 大连 116081
[Voltage-gated sodium channels are involved in regulating the biological functions of microglial cells.]
LI Bo-Wen, GOU Meng, XIAO Rong*, LI Qing-Wei*
College of Life Science, Liaoning Normal University, Lamprey Research Center, Dalian 116081, Liaoning, China
Microglial cells are widely distributed in the brain and spinal cord, and usually act as resident immune cells which could provide continuous monitoring roles within the central nervous system. When the cells in the central nervous system are injured, microglial cells are activated and induce a series of biological effects. Recently, several voltage-gated sodium channel subtypes were found to be expressed on the surface of the microglial cells which are able to participate in the regulation of the activation, phagocytosis, secretion of multiple cytokines/chemokines, migration, invasion of microglial cells, and etc. In the present study, the latest progresses on the regulation of voltage-gated sodium channel isoforms on microglial cells were summarized and analyzed. In addition, the mechanism and future research of the relationship between voltage-gated sodium channels and microglial cells were also discussed.
通讯作者：肖蓉,李庆伟 E-mail: email@example.com,
李博文, 勾萌, 肖蓉, 李庆伟. 钠离子通道参与调节小胶质细胞的生物学功能[J]. 生理学报 2015; 67 (1): 41-47.
LI Bo-Wen, GOU Meng, XIAO Rong, LI Qing-Wei. [Voltage-gated sodium channels are involved in regulating the biological functions of microglial cells.]. Acta Physiol Sin 2015; 67 (1): 41-47 (in Chinese with English abstract).