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New research advances in relationship of endoplasmic reticulum stress and cardiovascular diseases

JI Deng-Ren1, QI Yong-Fen1,2,3,*

1Laboratory of Cardiovascular Bioactive Molecule, School of Basic Medical Sciences, Peking University, Peking University, Beijing 100083, China;2Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center, Peking University, Beijing 100083, China;33Department of Pathogen Biology, School of Basic Medical Sciences, Peking University, Beijing 100083, China

Abstract

Endoplasmic reticulum (ER) is an important organelle for protein folding, post-transcriptional modification and transport, which plays an important role in maintaining cell homeostasis. A variety of internal and external environmental stimuli can cause the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum, and then result in ER stress. ER stress activates the unfolded protein response (UPR) and initiates a cluster of downstream signals to maintain ER homeostasis. However, severe and persistent ER stress activates UPR, which eventually leads to apoptosis and diseases. In recent years, a lot of researches suggest that ER stress plays an important role in the pathogenesis of various cardiovascular diseases (CVD), including ischemic heart disease, diabetic cardiomyopathy, heart failure, atherosclerosis and vascular calcification, high blood pressure and aortic aneurysm. ER stress might be one of the important targets for treatment of multiple CVD. Herein, the regulation mechanism of ER stress by activating UPR pathways in various common CVD and the new research advances in relationship of ER stress and CVD are briefly reviewed.


Key words: endoplasmic reticulum stress; unfolded protein response; cardiovascular disease

Received: 2019-08-28  Accepted: 2020-02-27

Corresponding author: QI Yong-Fen  E-mail: yongfenqi@163.com,yongfenqi@163.com,yongfenqi@163.com

DOI: 10.13294/j.aps.2020.0015

Citing This Article:

JI Deng-Ren, QI Yong-Fen. New research advances in relationship of endoplasmic reticulum stress and cardiovascular diseases. Acta Physiol Sin 2020; 72 (2): 190-204 (in Chinese with English abstract).