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Research progress in regulation of exercise on mitochondrial respiratory chain supercomplex

WANG Yan1,2, , BO Hai3,2

1School of Sports Science, Beijing Sport University, Beijing 100084, China;2Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Research Center for Exercise & Health Science, Tianjin University of Sport, Tianjin 310617, China;3Department of Military Training Medicines, Logistics University of Chinese People’s Armed Police Force, Tianjin 300162, China


The mitochondrial respiratory chain supercomplex (mitoSC) is a complex super-assembly formed by free complexes on the mitochondrial inner membrane respiratory chain through the interaction between their subunits, mainly including mitoSCI1+III2+IV1-4, mitoSCI1+III2, mitoSCIII2+IV1-2, high molecular weight mitoSC (HMW mitoSC) and mitochondrial metacomplex (mitoMC). mitoSC has been shown to improve the efficiency of electron transport in the respiratory chain and reduce the production of reactive oxygen species. The species and content of mitoSC change in different tissues in aging and many mitochondria-related diseases. By summarizing the structure and function of mitoSC in different tissues of human and mammals, and the changes of mitoSC under conditions of aging, heart disease, type 2 diabetes, cancer and genetic defects, this review focuses on the effects of exercise on mitoSC and its related regulation mechanisms in order to offer an insight for exercise interventions in mitochondria-related diseases.

Key words: mitochondrial respiratory chain supercomplex; exercise; reactive oxygen species; electron transport; mitochondria-related diseases

Received: 2019-08-26  Accepted: 2020-02-13

Corresponding author: ZHANG Yong  E-mail:

DOI: 10.13294/j.aps.2020.0016

Citing This Article:

WANG Yan, BO Hai, ZHANG Yong. Research progress in regulation of exercise on mitochondrial respiratory chain supercomplex. Acta Physiol Sin 2020; 72 (2): 205-219 (in Chinese with English abstract).