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Progress on the role of synaptic cell adhesion molecules in stress

WU Zhen-Zhen, WANG Xiao-Dong*

Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China

Abstract

Synaptic cell adhesion molecules (CAMs) are a type of membrane surface glycoproteins that mediate the structural and functional interactions between pre- and post-synaptic sites. Synaptic CAMs dynamically regulate synaptic activity and plasticity, and their expression and function are modulated by environmental factors. Synaptic CAMs are also important effector molecules of stress response, and mediate the adverse impact of stress on cognition and emotion. In this review, we will summarize the recent progress on the role of synaptic CAMs in stress, and aim to provide insight into the molecular mechanisms and drug development of stress-related disorders.


Key words: synaptic cell adhesion molecules; stress; learning and memory; emotion

Received: 2019-08-27  Accepted: 2019-10-17

Corresponding author: WANG Xiao-Dong  E-mail: xiaodongwang@zju.edu.cn

DOI: 10.13294/j.aps.2020.0020

Citing This Article:

WU Zhen-Zhen, WANG Xiao-Dong. Progress on the role of synaptic cell adhesion molecules in stress. Acta Physiol Sin 2020; 72 (2): 220-226 (in Chinese with English abstract).