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Research advances on adrenergic receptor signaling involved in disease microenvironment through regulation of macrophages

WANG Ji-Ju1, LI Da-Jin1,2,3,

1Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China;2Key Laboratory of Reproduction Regulation of National Population and Family Planning Commission (NPFPC), Shanghai 200032, China;3Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China

Abstract

Adrenergic receptor (AR), one of the key receptors for nervous system, plays an important role in the immune microenvironment and the progression of many diseases. In recent years, the regulation of ARs and its signal on macrophages has become a research hotspot. Researchers found that ARs could exert different regulatory functions on macrophages in different microenvironments, which in turn affects occurrence and development of diseases such as tumor, heart failure, obesity, acute injury, infection and pregnancy-related diseases. This review summarizes the expression and functional regulation of ARs on macrophages, and the role of ARs in microenvironment of related diseases, which might provide new ideas for the treatments.


Key words: adrenergic receptors; macrophages; functional regulation; microenvironment of related diseases

Received: 2019-08-28  Accepted: 2020-02-13

Corresponding author: DU Mei-Rong  E-mail: mrdu@ fudan.edu.cn,mrdu@ fudan.edu.cn,mrdu@ fudan.edu.cn

DOI: 10.13294/j.aps.2020.0010

Citing This Article:

WANG Ji-Ju, LI Da-Jin, DU Mei-Rong. Research advances on adrenergic receptor signaling involved in disease microenvironment through regulation of macrophages. Acta Physiol Sin 2020; 72 (2): 227-234 (in Chinese with English abstract).