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Role of adrenergic receptors in tumorigenesis and development of glioma

HE Ye1, ZHU Yu-Ge2, LIU Wei-Zhu3, ZHANG Wen-Hua3, PAN Bing-Xing3, HU Ping2,*

1Center for Basic Medical Experiment, Nanchang University, Nanchang 330031, China;2The Center for Biotechnology and Biopharmaceutics, Institute of Translational Medicine, Nanchang University, Nanchang 330031, China;3Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang 330031, China

Abstract

Gliomas are malignant tumors with strong invasiveness. The current treatment strategy is surgical treatment assisted by a variety of radiotherapies, chemotherapies and immunotherapies. However, the curative efficacy is limited. Adrenergic receptor (AR) is an important stress hormone receptor, which is highly involved in the regulation of the tumorigenesis and progression of various tumors by activating different downstream signal transduction pathways. Recent studies have shown that AR is dysregulated in glioma cells and tissues, and plays an important role in a series of biological behaviors such as tumorigenesis, invasion and metastasis of glioma. This article reviews the research progress of AR in the field of glioma in recent years, which provides a theoretical basis for the prevention and treatment of glioma targeting the AR.


Key words: glioma; adrenergic receptor; chronic stress; tumor growth

Received: 2019-08-24  Accepted: 2020-01-02

Corresponding author: HU Ping  E-mail: canyhp@163.com

DOI: 10.13294/j.aps.2020.0011

Citing This Article:

HE Ye, ZHU Yu-Ge, LIU Wei-Zhu, ZHANG Wen-Hua, PAN Bing-Xing, HU Ping. Role of adrenergic receptors in tumorigenesis and development of glioma. Acta Physiol Sin 2020; 72 (2): 235-242 (in Chinese with English abstract).