5-羟色胺抑制谷氨酸对海马神经元的毒性作用

Suppression of glutamate neurotoxicity by 5-HT in hippocampal neurons

马强  刘卫  吴丽颖  晁福寰 

摘 要:为探讨5-羟色胺(5-HT)对过量谷氨酸(glutamate,Glu)神经毒性的影响,观察了5-HT存在时,过量Glu对海马细胞存活率、海马脑片CA1区群锋电位(population spike,PS)及神经细胞膜Ca2+电流的影响。结果发现:5-HT可明显提高过量Glu作用下海马神经细胞的存活率,减缓Glu对海马脑片CA1区PS的降低作用;在细胞膜上,5-HT可明显减弱Glu诱导的Ca2+内向电流。推测,一定浓度的5-HT具有抑制过量Glu神经毒性的作用,其机制可能在于5-HT与细胞膜上特定的受体结合,抑制了Glu诱导的Ca2+内流。
关键词:5-羟色胺 (5-HT); 谷氨酸 (Glu); 海马神经细胞; 应激
分类号:Q421; R338 文献标识码:A

 

作者单位:马强(军事医学科学院卫生学环境医学研究所, 天津 300050) 
     刘卫(军事医学科学院药物毒物研究所) 
     吴丽颖(基础医学研究所, 北京 100850) 
     晁福寰(军事医学科学院卫生学环境医学研究所, 天津 300050) 

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收稿日期:2000年10月15日

修稿日期:2000年12月15日