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基金项目：This work was supported by National Major Basic Research Program
(G2000056905).
作者单位：曹军（北京大学第一医院心血管研究所）
曹军（宁夏医学院病理生理教研室, 银川 750004）
王蕾（北京大学第一医院神经研究中心, 北京 100034）
赵保路（中国科学院生物物理研究所, 北京 100101）
陈清棠（北京大学第一医院神经研究中心, 北京 100034）
齐永芬（北京大学第一医院心血管研究所）
唐朝枢（北京大学第一医院心血管研究所）
参考文献：
［1］Brown GC. Nitric oxide and mitochondrial respiration.
Bio～chim Biophys Acta, 1999, 1411(2-3):351～369.
［2］Bolnos JP, Almeida A, Heales SJR. Nitric oxide-mediated mitochondrial
damage in the brain: mechanisms and implications for neurodegenerative
diseases. J Neurachem, 1997, 68:2227～2240.
［3］Giulivi C,Poderoso JJ,Boveris A.Production of nitric oxide by mitochondrial.J
Biol Chem,1998, 273(18):11038～11043.
［4］Brorson JR, Schumacker PT, Zhang H. Nitric oxide acutely inhibits neuronal
energy production. The Committees on Neurobiology and Cell Physiology. J
Neurosci, 1999, 19(1):147～158.
［5］Wang Lei (王蕾), Tang CS (唐朝枢), Zhao BL(赵保路) et al. Production of nitric
oxide by mitochondrial of brain in rat. Natl Med J Chin (中华医学杂志), 2000,
80(7):544～545.
［6］Lai JK, Clark JB. Preparation of synaptic and nonsynaptic mitochondria
from mammalian brain. Methods Enzymol, 1979, 55:51～60.
［7］Simis RN. Rapid isolation of metabolically active mitochondria from rat
brain and subregions using percoll density grandient centrifugation. J
Neurochemistry, 1990, 55:689～707.
［8］Swanson MA. Glucose-6-phosphatas from liver. Methods En～zymol, 1955, 2:541～543.
［9］Fretes-RE, De-Fabro-SP. In vivo and in vitro analysis of lysosomes and
acid phosphatase activity in human chagasic placentas. Exp Mol Pathol, 1995,
63(3):153～160.
［10］Durante W, Liao L, Iftikhar J et al. Differential regulation of L-arginine
transport and nitric oxide production by vascular smooth muscle and
endothelium. Circ Res, 1996, 78:1075～1083.
［11］Zhang XB (张新波),Huang HL (黄海鹭),Zhang LZ (张灵芝) et al. Measurement of nitric
oxide synthase activity and its application. J Beijing Med Univ (北京医科大学学报),
1994, 26(Suppl):173～176 (Chinese, English abstract).
［12］Green LG, Wager DA, Glogowski L et al. Analysis of nitrate nitrite and
[15N] nitrate in biological fluids. Anal Biochem, 1982, 126:131～136.
［13］Tatoyan A, Giulivi C. Purification and characterization of a nitric oxide
synthase from rat liver mitochondria. J Biol Chem, 1998, 332:673～679.
［14］Tang CS (唐朝枢), Tang jian (汤健). Nitric oxide and diseases. Chin Med J (中华医学杂志),
1998, 78(1):5.
［15］Zheng HZ(郑惠珍),Tang CS(唐朝枢),SU JL(苏加林) et al.Effects of myocardial
ischemia reperfusion injury on L-arginine/nitric oxide system in rat heart.
Acta Physiol Sin(生理学报),1999,51(1):25～30 (Chinese, English abstract).
［16］William WS, Ellen IC, James MC et al . Cytokines and insulin induce
cationic amino acid transporter (CAT) expression in cardiac myocytes. J Bio
Chim, 1996, 271(20):11694～11702.
［17］郑惠珍, 唐朝枢. L-精氨酸的跨膜转运及临床意义. 国外医学 (生理、病理科学与临床分册), 1999, 6(19):475～478.
［18］Hotta Y, Otsuka MH, Fujjta M et al. Protective role of nitric oxide
synthase against mit ischemia-reperfusion injury in guinea pig myocardial
mitochondria. Eur J Pharmacol, 1999,380(1):37～48.
［19］Abe K, Hayashi N, Terada H. Effect of endogenous nitric oxide on energy
metabolism of rat heart mitochondria during ischemia and reperfusion. Free
Radic Biol Med, 1999, 26(3～4):379～387.
［20］Ghafuorifar P, Richter C. Mitochondria nitric oxide synthase regulates
mitochondria matrix pH. Biol Chem, 1999, 380(7～8):1025～1028.
收稿日期：2000年10月27日
修稿日期：2000年12月15日
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