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摘 要:
用行为学和电生理学的方法,
探讨脚内核在电针镇痛及兴奋尾壳核镇痛中的作用。脚内核微量注射红藻氨酸7
d后,
电针对辐射热引起的大鼠缩腿潜伏期无明显影响,
电针或兴奋尾壳核对丘脑束旁核神经元的伤害性反应亦无明显影响。
与正常对照组电针或兴奋尾壳核产生的抑制作用相比有显著性差异(Ｐ<0.05)；
与脚内核微量注射生理盐水7
d后,
电针可提高大鼠缩腿潜伏期,
及电针或兴奋尾壳核对束旁核神经元伤害性反应的抑制作用相比，
有显著性差异(Ｐ<0.05)。上述结果提示,
脚内核在电针及兴奋尾壳核镇痛中发挥重要作用。
关键词:
脚内核；
尾壳核；
电针镇痛
学科分类号:
Q426; R245
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Roles of entopeduncular nucleus in acupuncture
analgesia and caudate-putamen
nucleus s
timulation-induced analgesia
WU Guo-Ji, CHEN Zheng-Qiu, SHI Hong
(Institute of Acupuncture, China Academy of Traditional Chinese
Medicine, Beijing 100700)
Abstract:
The present study was to investigate whether entopeduncular nucleus (EP)
is involved in caudate-putamen nucleus (CPu) stimulation-induced analgesia
and in acupuncture analgesia. It was found that the foot-withdrawal
latency elicited by radiant heat exposure was increased after
electroacupuncture analgesia (EA), and the nociceptive responses of
neurons in parafascicular nucleus (Pf) were inhibited after EA or after
excitation of CPu neurons in normal rats, but the foot-withdrawal latency
and nociceptive responses of Pf neurons were unchanged by EA or excitation
of CPu in the rats with lesion of EP by local application of kainic acid.
The results obtained with microinjeciton of saline instead of kainic acid
into the EP were the same with those in the nonlesioned control group. The
differences in the results between the lesion group and the other groups
were significant (Ｐ<0.05).
It is suggested that EP is involved in acupuncture analgesia and also
plays an important role in caudate-putamen nucleus stimulation-induced
analgesia.
Key words:
entopeduncular nucleus; caudate-putamen nucleus; electroacupuncture
analgesia
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