^*Corresponding author. Tel: +86-21-64154900; Fax: +86-21-64154900; E-mail: chengq@shsmu.edu.cn

This work was supported in part by National Key Program (973) for Basic Research of China (No. 2002CB512806), National Natural Science Foundation of China (No. 90408009 and 30500257) and Science and Technology Committee of Shanghai (No. 03XD14016, 05JC14032).

Phospholipid scramblase 1

HUANG Ying¹, ZHAO Qian¹, CHEN Guo-Qiang^1,2,*

¹Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiaotong University School of Medicine; ²Institute of Health Science, SJTU-SM/Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

Abstract：Phospholipid scramblase 1 (PLSCR1) is a calcium-binding, multiply palmitoylated type II endofacial plasma membrane protein，while unpalmitoylated PLSCR1 protein can import into the nucleus, where it binds to genomic DNA. Although the original work showed that PLSCR1 contributes to the transbilayer movement of phospholipids, the following studies revealed that PLSCR1 expression can be induced by some cytokines such as interferon, epidermal growth factor, and also by leukemic cell differentiation-inducing agents such as all-trans retinoic acid (ATRA) and phorbol 12-myristate 13-acetate (PMA). PLSCR1 was also shown to interact with several protein kinases including c-Abl, c-Src, protein kinase Cd as well as some other proteins such as onzin, suggesting the roles of PLSCR1 in cell signaling. Indeed, the current evidence proposes that PLSCR1 contributes to cell proliferation, differentiation, apoptosis, and plays roles in the pathogenesis of cancers, especially leukemia.

Key words: phospholipid scramblase 1 (PLSCR1); physiology; pathophysiology; leukemia

磷脂爬行酶1

黄莹^1,2，赵 倩¹， 陈国强^1,2,*

¹上海交通大学医学院病理生理学教研室、细胞分化与凋亡教育部重点实验室；²上海交通大学医学院/上海生命科学研究院健康科学研究所

摘 要：磷脂爬行酶1 (phospholipid scramblase1, PLSCR1)属于Ca²⁺结合的棕榈酰化II型膜蛋白，而非棕榈酰化的PLSCR1蛋白可定位于细胞核内，并与基因组DNA序列结合。最初的研究显示，PLSCR1参与细胞膜磷脂跨膜活动。随后的研究发现多种细胞因子如干扰素、表皮生长因子等和白血病细胞分化诱导剂如全反式维甲酸(ATRA)、佛波酯(PMA)等也能够调节PLSCR1的表达。尤其重要的是，PLSCR1蛋白可与多种蛋白如c-Abl、EGFR、c-Src、PKCd和onzin等相互作用，提示PLSCR1在细胞信号传递中的作用。越来越多的证据表明PLSCR1的确参与细胞生长、分化、凋亡过程，并可能与肿瘤尤其与白血病发病学存在关系。

关键词：磷脂爬行酶1；生理学；病理生理学；白血病