Abstract It has been postulated that Angiotensin Ⅱ type 2 receptor (AT2) functionally antagonizes ac 1 (AT1) receptor. In the present study, we investigated whether gene deletion of AT2 receptor causes the compensatory chaos of renin-angiotensin system in mice. It was shown that the concentrations of Angiotensin Ⅱ in plasma and kidney tissues and the expressions of renin and AT1A receptor in the AT2 gene null face were unchanged, as compared with those in AT2 wild-type mice. Thiss result suggests that gene deletion of AT2 receptor does not markeddly impact the stability of renin-angiotensin system all the inductive function of AT2 receptor is compensated in a way remaining to be clarified.
Key words
AT2 receptor gene deletion renin-angiotensin system
|
