Chen CHEN 

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Curriculum Vitae

 

1)  Name in full: Chen CHEN

2)  Sex:       Male

3) Date of birth: April 21, 1957.

4) Place of Birth: Xi¡¯an, People¡¯s Republic of China.

5)  Home address:    3 Royalty Street, Clayton, Victoria 3168, Australia. Tel: (61-3) 9515-7723 or 0409 416 386

6) Business address:   Endocrine Cell Biology, Prince Henry's Institute of Medical Research,

P. O. Box 5152, Clayton, Victoria 3168, Australia

   Tel: (61-3) 9594-4371; Fax: (61-3) 9594-6125; E-mail: chen.chen@med.monash.edu.au

7) Web site of the Institute: http://www.med.monash.edu.au/phimr/CellBiol.html

8)  Academic record and postdoctoral fellowship:

       Feb. 1978--Dec. 1982.  School of Medicine, Shanghai Medical University, Shanghai, P. R. China.  Bachelor of Medicine

       Feb. 1983--Oct. 1986.  Postgraduate student for Master of Science degree at the Department of Physiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. China.

       Oct. 1986--Oct. 1990.  Postdoctoral (Medical Doctor) fellowship supported by "Foundation pour la Recherche Medicale and INSERM" and postgraduate student for "Doctorat en Sciences" (French Ph.D.) in the University de Bordeaux II, Bordeaux, France

       Oct. 1989--Jun. 1991.  Research Associate and Postdoctoral Research Fellow at the Department of Analytical Pharmacology, Glaxo Inc. Research Institute, North Carolina, U.S.A.

9) Current status:

       Senior Research Fellow, Australian National Health & Medical Research Council

       Head, Endocrine Cell Biology, Prince Henry¡¯s Institute of Medical Research

       Honorary Senior Lecturer, Department of Physiology, Monash University, Australia

       Visiting Professor, Department of Physiology, Peking Union Medical College, China

Visiting Professor, Department of Pharmacology, University of Alberta, Edmonton, Canada

Honorary Professor, The Fourth Military Medical University, Xi¡¯an, China

10) Professional Membership:  

              Endocrine Society of Australia (ESA);

              International Society for Neurochemistry (ISN);

              Society for Neuroscience (SFN);

              Australian Physiological and Pharmacological Society (APPS);

  National Society of Research Fellows in NHMRC

Member of Cambridge International Biographical Centre Advisory Council

11)  Editorial duties:

Editorial board member: ¡°Endocrine¡±, ¡°Current Drug Target¡±, ¡°Clinic and Experimental Pharmacology and Physiology¡±, ¡°Acta Physiologica Sinica¡±

Referee for Journals: J Physiol, Am J Physiol, Endocrinology, J Endocrinol, Neuroendocrinology, J Neuroendocrinol, J Clin Endocrinol Metab, Neuroscience, J Neurosci, Clin Exp Physiol Pharmacol, Brain Res, Life Sci, etc.

Referee for Funding agents: NHMRC, US Growth Foundation, Wellcome Foundation, New Zealand HRC, ARC, Singapore NMRC, etc.

12) Completed research projects:

In China (Feb., 1983-Oct., 1986):

Topic:  Neurobiological studies on the central and peripheral relations between sympathetic and parasympathetic nervous systems.

This research in China was published in 8 papers (Publication list #1-8) and I was invited to speak at the Chinese Symposium of Cardiovascular Regulation, 1984 and to speak at the Conference of Chinese Physiological Society, 1985.

In France (Oct., 1986 - Oct., 1989):

Topic Electrophysiological properties and hormone secretions of anterior pituitary cells in culture: intracellular recording, patch-clamp recording, hormone radioimmunoassay and reverse haemolytic plaque assay studies.

These data were published in 10 original papers, one thesis and 4 reviews (Publication list #9-19, 21-22, 24, 29) and I have been invited to speak at Workshop in Brussels, Belgium 1988, at Conference INSERM, France 1987, 18th Meeting of the Society of Experimental Neuroendocrinology, France 1988, and the International Meeting on Regulation of Somatic Growth, Spain 1991.

In the United States (Oct, 1989 - May, 1991):

Topics 1:  Molecular mechanism underlying the vascular smooth muscle contraction induced by endothelin

Topics 2: Effects of amylin on pancreatic b-cell stimulus-secretion coupling

These data have been published in 2 papers and been presented at the 63rd Scientific Sessions of American Heart Association, Dallas, USA 1990, 52nd Annual Meeting of The American Diabetes Association, 1991 and at the 37th Annual Meeting of U. S. A. Biophysical Society, 1993.

In Australia (June 1991- ):

       Since coming to Australia June 1991, I had set up a modern electrophysiology laboratory and several new techniques including Nystatin-perforated patch-clamp, membrane capacitance measurement method, continuous perifusion system, Fura-2 and Indo-1 intracellular Ca2+ measurement, immunocytochemistry, pituitary cell separation, and several molecular biology (Northern analysis and quantitative RT-PCR) techniques. I had submitted application and succeeded in obtaining NH & MRC research project grants (1992-1994, 1996-2000, 1999-2003, 2001-2003), National Nature Science Foundation Grant of China (type B, 2001-2003), Aza Research Grant, US Human GH Grant and several other private funds.

13)  Competitive Research Supports and Awards:

1.   Chinese National Postgraduate Scholarship, Beijing, China; 1983-1986.

2.   Travel award from the Symposium of Cardiovascular Regulation in China for excellent young scientists to attend the symposium, Fujian, China, 1984.

3.   Award to excellent young physiologist in China to attend and give a lecture at the Conference of Chinese Physiological Society, Sichuan, China, 1985.

4.   "Foundation pour la Recherche Medicale" or Medical Research Foundation Postdoctoral Fellowship Award, Paris, France; 1986-1988.

5.   Research Support from "Institut national de la sante et de la Recherche Medicale" (INSERM), Unit 176, Bordeaux, France; 1988-1989.

6.   Postdoctoral Research Fellowship at Glaxo Inc., Research Triangle Park, North Carolina, USA; 1989-1991.

7.   Australian National Health and Medical Research Council (NH & MRC) research project grant (# 920245), Commonwealth of Australia, Canberra, Australia; 1992-1994 (Principal investigator).

8.   GHRP Research Project Fund, Kaken pharmaceutical company, Tokyo; Japan, 1992-1993 (C. Chen, Principal investigator).

9.   Eli Lilly Growth Research Award, Eli Lilly, West Ryde, NSW, Australia; 1992.

10. Travel Award from Australian Society of Physiology and Pharmacology and Endocrine Society of Australia for giving a lecture in the Symposium "Ion Channels and Patch-Clamping", Canberra, Australia, February 1993.

11. Travel Award from International Society of Neurochemistry for attending the First School of Neurochemistry, Montpellier, France, August 1993.

12. Travel Award from the Ian Potter Foundation for attending the 14th Biennial Meeting of the International Society for Neurochemistry, Montpellier, France, August 1993.

13. Travel Award from the Hong Kong Chinese University for giving a talk at the Department of Pharmacology, Hong Kong, 1994.

14. Travel Award from Singapore Neuroscience Society for giving a talk at the Asia-Pacific Colloquium in Neuroscience, Singapore, 1994.

15. Travel Award from Europeptide for giving a talk at the Asia-Pacific Colloquium in Neuroscience, Singapore, 1994.

16. Servier Award for best scientific paper from The Endocrine Society of Australia, 1994.

17. The William Buckland Foundation support to a research project 'Molecular mechanism of hormone secretion', 1994.

18. Travel Award from The Serono Symposium on GH Secretagogues, USA, 1994.

19.        Research Grant for 1995 from the Prince Henry's Specialist Foundation, Melbourne, 1995.

20.        Travel Award from the Prince Henry's Specialist Foundation to attend The Serono Symposium in USA, 1994.

21.        Australian National Health and Medical Research Council (NH & MRC) research project grant (5-year Research Fellowship Grant), Commonwealth of Australia, Canberra, Australia; 1996-2000 (C. Chen, Principal investigator).

22. Travel Award from the International Endocrine Society (IES) to attend the Conference of IES in USA, 1996.

23. Equipment Grant from the Prince Henry's Whole-time Specialist Foundation, Melbourne, 1996.

24. Travel Award from the Merck Research Laboratories, Rahway, USA, 1996.

25. Travel Award from The 2nd International Symposium on GH Secretagogues, Tampa, USA, 1997.

26. Equipment Grant from the R.L. Cooper Medical Research Foundation, Sydney, Australia, 1997.

27.        Aza Research Project Grant from Aza Research Pty. Ltd, 1998-1999, (C. Chen, Principal investigator).

28.        Human Growth Foundation Project Grant, USA, 1998-1999, (C. Chen, Principal investigator).

29.        Travel Award from the Ian Potter Foundation for attending the 11th Asia-Oceania Congress of Endocrinology, Seoul, Korea, 1998.

30.  Alberta Heritage Foundation Visiting Professor Award, Edmonton, Canada, 1998.

31.  Australian National Health and Medical Research Council (NH & MRC) research project grant (5-year Research Fellowship Grant), Commonwealth of Australia, Canberra, Australia; 1999-2003 (C. Chen, Principal investigator).

32.  Travel Award by the International Society of Neurochemistry to give a symposium at the ISN conference, Berlin, 1999.

33.  Travel Award from The 3rd International Symposium on GH Secretagogues, Colorado, USA, 2000.

34.  Invited delegate of the ¡®100 Overseas Chinese PhDs¡¯ to attend the official celebration of the 50th Anniversary of PR China.

35.  Australian National Health and Medical Research Council (NH & MRC) research project grant, Commonwealth of Australia, Canberra, Australia; 2001-2003 (C. Chen, Principal investigator).

36.  National Nature Science Foundation of China research project grant, Beijing, China; 2001-2003 (C. Chen, Principal investigator).

14) Administration:

       Member of Research Management Committee, Prince Henry¡¯s Institute of Medical Research;

       Member of Scientific Staff Committee, Prince Henry's Institute of Medical Research;

       Member of Computer Committee, Prince Henry's Institute of Medical Research;

       Member of Staff Committee, Department of Physiology, Monash University.

15) List of 20  publications:

* C Chen is Corresponding Author.

a. Paper in refereed journal    a'. Review in refereed journal

b. Chapter in book

1 (a').* Chen CHEN: (1985) Role of endothelium cell in the vascular relaxation. Physiological Sciences, 4(2):11-14. (in Chinese).

2 (a').* Chen CHEN and Meng-Chin CHEN: (1985) Arterial wall renin-angiotensin-system and its role in hypertension. Physiological Sciences, 5(2):65-70. (in Chinese).

3 (a).  Wen-Min ZOU, Chen CHEN and Meng-Chin CHEN: (1986) Relations between depressor effect induced by stimulation of peripheral ends of abdominal vagi and serotonin.  Acta of Academy of Medicine Sinicae, 8(3): 180-184 (in Chinese).

4 (a).  Li-Tian SHEN, Da-Wei ZHANG, Yan CHEN, Chen CHEN and Meng-Chin CHEN: (1986) Power spectral estimation analysis and its use on evaluate the renal neural activity.  Beijing Biomedical Engineering, 6(2): 51-54 (in Chinese).

5 (a).* Chen CHEN, Yan CHEN and Meng-Chin CHEN: (1987) A study on the pressor mechanism of abdominal vagus.  Proceedings of Chinese Academy of Medical Sciences, 2(1): 16-21 (in English).

6 (a).  Ying-Nian CAI, Xi-Xian DEN, Meng-Chin CHEN, Zhi-Liang WANG, Bao-Sheng QI, Chen CHEN and Wen-Li LIU: (1987) Central effect on pulmonary pressor response during hypoxia in dogs.  Proceedings of Chinese Academy of Medical Sciences,  2(4)l220-225 (in English).

7 (a).  Meng-Chin CHEN, Chen CHEN, Yan CHEN, Qi ZHANG, Hong-Xiang WANG, Xui-Wen ZHAO and Bin REN: (1988) Studies on the cervical and abdominal vagal pressor responses in the cat. Acta Physiologica Sinica 40(6): 561-568 (in Chinese).

8 (a).* Chen CHEN, Meng-Chin CHEN, Hong-Xiang WANG and Yan CHEN: (1989) The role of the nucleus tractus solitarius and the locus coeruleus in the abdominal vagal pressor response.  Proceedings of Chinese Academy of Medical Sciences, 4(3): 142-146 (in English).

9 (a).* Chen CHEN, Jean-Marc ISRAEL and Jean-Didier VINCENT: (1989) Electrophysiological responses to somatostatin of rat hypophysial cells in somatotroph-enriched primary cultures. Journal of Physiology (London), 408:493-510.

10 (a).* Chen CHEN, Jean-Marc ISRAEL and Jean-Didier VINCENT: (1989) Electrophysiological responses of rat pituitary cells in somatotroph-enriched primary culture to human growth hormone-releasing factor.  Neuroendocrinology, 50:679-687.

11. (a¡¯)* Chen CHEN: (2000) Growth hormone secretagogue actions on the pituitary gland: multiple receptors for multiple ligands? Clinical and Experimental Pharmacology and Physiology, 27: 323-329.

12. (a¡¯)* Chen CHEN: (1999) A highly specific approach for studying intracellular signalling and membrane ion channels. Chinese Physiological Communication, (invited review), 18: 32-34.

13. (a) H. ISHIWATA, M. NAGANO, Y. SASAKI, Chen CHEN and K. KATOH: (2000) Short-chain fatty acids inhibit the release and content of growth hormone in anterior pituitary cells of the goat. General & Comparative Endocrinology, 118: 400-406.

14. (a¡¯)* Chen CHEN, Ruwei XU, Iain J. CLARKE, Ming RUAN, Kylie LONERAGAN and Sang-gun ROH: (2000) Diverse intracellular signalling systems used by growth hormone-releasing hormone in regulating voltage-gated Ca2+ or K+ channels in pituitary somatotropes. Immunology and Cell Biology, 78: 356-368.

15. (c)* Chen CHEN: (2000) Diverse intracellular signalling systems employed by growth hormone releasing or inhibitory hormones in regulating membrane ion channels in pituitary somatotropes. 2000 Symposium on Neuroscience (Hefei, China), pp266-276.

16. (a¡¯)* Chen CHEN, Sang-gun ROH, Arieh GERTLER, and Kylie LONERAGAN: (2001) Effect of leptin on GHRH and GHRP-receptor synthesis in ovine somatotropes in vitro. Endcorine, 14: 73-78.

17. (b)* Chen CHEN: (2001) Cell biology and membrane function. Chapters for Chinese ¡®Textbook of Medical Physiology¡¯ (by invitation).

18. (a¡¯)* Chen CHEN: (2001) Multiple intracellular signalling systems involved in regulating activity of membrane ion channels by hypothalamic GH releasing or inhibitory hormones in primary cultured somatotropes. Progress in Natural Sciences, 11: 161-172.

19. (a)* Sang-Gun ROH, Gui-Ying NIE, Kylie LONERAGAN, Arieh GERTLE and Chen CHEN (2001) Direct modification of somatotrope function by long-term leptin treatment of primary cultured ovine pituitary cells. Endocrinology, 142: 5167-5171.

20. (a) Ming YAN, Dong Ling LIU, Yeow Leng CHUA, Chen CHEN and Yean Leng LIM (2001) Effects of micromolar concentrations of manganese, copper, and zinc on a1-adrenoceptor-mediating contraction in rat aorta. Biological Trace Element Research, 82: 159-166.