Dr. and prof. Guo-Qiang Chen is currently responsible for the Department of Pathophysiology and Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine(SJTU-SM). He is also director of Div. Cancer Genomics, Institute of Health Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/SJTU-SM.

He got his Master and the Ph.D degrees in Shanghai Second Medical University (presently SJTU-SM), respectively in 1985 and 1996. Afterwards, he also worked as visiting assistant professor in Paris and New York respectively in 1997 and 1999-2001. During the recent more than ten years, Dr. Chen has been devoted his efforts on the basic research about pathogenesis and therapeutics of leukemia. Meanwhile, he published up to 40 articles in the international peer-reviewed journals such as Blood, Leukemia, JBC, which were cited totally by about 2200 of literatures. These publications mainly involved the discoveries as following: (1) In vitro and in vivo effects of arsenic trioxide (As₂O₃), an effective drug for the treatment on acute promyelocytic leukemia (APL), on leukemic and other malignant cells. Those related discoveries were highly evaluated by the journals such as Science and JNCI; (2) Discoveries of hypoxia-induced AML cell differentiation and elucidation of its molecular mechanisms; (3) Regulation of the expression of phospholipid scramblase 1 (PLSCR1) by protein kinase Cδ (PKCδ) and its roles in the process of leukemic cell differentiation; (4) NSC606985 can effectivly induce the cell apoptosis in AML and its signal pathway; (5) the biological roles of leukemia related protein AML-ETO and found that AML-ETO can increase the sensitivity of leukemic cells to cell apoptosis and inhibit the cell proliferation  through up-regulating the expression of CX43.

Main publications:

1.        Lu Y, Xu YB, Yuang TT, Song MG, Michael Lubbert, Manfred Fliegauf, Chen GQ. Inducible Expression of AML1-ETO Fusion Protein Endows Leukemic Cells with Susceptibility to Extrinsic and Intrinsic apoptosis. Leukemia, 2006, in press.

2.         Han YH, Xia L, Song LP, Zheng Y,  Chen WL,  Zhang L,  Huang Y, Chen GQ,  Wang LS. Comparative Proteomic Analysis of Hypoxia-treated and Untreated Human Leukemic U937 cells. Proteomics, 2006 in press.

3.        Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Peter J. Sims, Zhao KW, Chen GQ. Anti-leukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells. Oncogene, 2006, in revision.

4.        Jin X, Xia L, Wang LS, Shi JZ, Zheng Y, Chen WL, Zhang L, Liu ZG, Chen GQ, Fang NY.Differential protein expression in hypertrophic heart with and without hypertension in spontaneously hypertensive rats.Proteomics. 2006; 6(6):1948-56 PMID: 16485256 [PubMed - as supplied by publisher]

5.        Guo M, Song LP, Jiang Y, Liu W, Yu Y, Chen GQ.Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms.Apoptosis. Apoptosis. 2006 Jan;11(1):67-77. 2005 Dec 21; [Epub ahead of print] PMID: 16374551 [PubMed - as supplied by publisher]

6.         Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ.Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia.Blood. 2006 Jan 15;107(2):698-707. Epub 2005 Sep 15. PMID: 16166593 [PubMed - in process]

7.        Zhang L, Wang LS, Xia L, Chen WL, Zheng Y and Chen GQ. Comparative proteomic analysis of human leukemic cells with and without inducible expression of leukemogenic AML1-ETO protein. Chinese J Physiology 2006; in press

8.        Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica. 2005 Dec;90(12):1607-16. PMID: 16330433 [PubMed - in process]

9.        Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ. Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.J Biol Chem. 2005 Dec 30;280(52):42707-14. Epub 2005 Oct 28. PMID: 16260419 [PubMed - in process]

10.    Li Z, Liu Q, Song M, Zheng Y, Nan P, Cao Y, Chen G, Li Y, Zhong Y. Detecting correlation between sequence and expression divergences in a comparative analysis of human serpin genes.Biosystems. 2005 Dec;82(3):226-34. Epub 2005 Aug 19. PMID: 16112386 [PubMed - in process]

11.    Fu GH, Wang Y, Xi YH, Guo ZW, Liu XB, Bai SZ, Yang BF, Chen GQ.  As₂O₃ enhances the anion transport activity of band 3 and the action is related with the C-terminal 16 residues of the protein(dagger). J Drug Target. 2005 May;13(4):235-43. PMID: 16051535 [PubMed - indexed for MEDLINE]

12.    Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ, Zhao Q.Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1alpha protein. Biochem Biophys Res Commun. 2005 Jul 15;332(4):1140-5.PMID: 15935329 [PubMed - indexed for MEDLINE]

13.    Jiang Y, Xue ZH, Shen WZ, Du KM, Yan H, Yu Y, Peng ZG, Song MG, Tong JH, Chen Z, Huang Y, Lubbert M, Chen GQ.  Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha. Leukemia. 2005 Jul;19(7):1239-47.PMID: 15902299 [PubMed - indexed for MEDLINE]

14.    Yu Y, Chen S, Wang LS, Chen WL, Guo WJ, Yan H, Zhang WH, Peng CH, Zhang SD, Li HW, Chen GQ.  Prediction of pancreatic cancer by serum biomarkers using surface-enhanced laser desorption/ionization-based decision tree classification.Oncology. 2005;68(1):79-86. Epub 2005 Apr 8.PMID: 15864000 [PubMed - indexed for MEDLINE]

15.    Fu GH, Wang Y, Xi YH, Shen WW, Pan XY, Shen WZ, Jiang XS, Chen GQ.  Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1).FEBS Lett. 2005 Apr 11;579(10):2105-10.PMID: 15811326 [PubMed - indexed for MEDLINE]

16.    Song MG, Gao SM, Du KM, Xu M, Yu Y, Zhou YH, Wang Q, Chen Z, Zhu YS, Chen GQ.  Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms.Blood. 2005 May 1;105(9):3714-21. Epub 2005 Jan 25.PMID: 15671440 [PubMed - indexed for MEDLINE]

17.    Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, Jin XL, You JH, Yang G, Shen ZX, Chen J, Xiong SM, Chen GQ, Xu F, Liu YW, Chen Z, Chen SJ.AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1104-9. Epub 2005 Jan 13.PMID: 15650049 [PubMed - indexed for MEDLINE]

18.    Yin T, Wu YL, Sun HP, Sun GL, Du YZ, Wang KK, Zhang J, Chen GQ, Chen SJ, Chen Z.Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein.Blood. 2004 Dec 15;104(13):4219-25. Epub 2004 Aug 31.PMID: 15339852 [PubMed - indexed for MEDLINE]

19.    Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ.  Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation.Blood. 2004 Dec 1;104(12):3731-8. Epub 2004 Aug 12.PMID: 15308560 [PubMed - indexed for MEDLINE]

20.    Zhao Q, Tao J, Zhu Q, Jia PM, Dou AX, Li X, Cheng F, Waxman S, Chen GQ, Chen SJ, Lanotte M, Chen Z, Tong JH.Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation.Leukemia. 2004 Feb;18(2):285-92.PMID: 14628075 [PubMed - indexed for MEDLINE]

21.    Huang Y, Du KM, Xue ZH, Yan H, Li D, Liu W, Chen Z, Zhao Q, Tong JH, Zhu YS, Chen GQ. Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha.Leukemia. 2003 Nov;17(11):2065-73.PMID: 14523474 [PubMed - indexed for MEDLINE]

22.    Cai X, Yu Y, Huang Y, Zhang L, Jia PM, Zhao Q, Chen Z, Tong JH, Dai W, Chen GQ. Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells.Leukemia. 2003 Jul;17(7):1333-7. PMID: 12835721 [PubMed - indexed for MEDLINE]

23.    Chen GQ, Zhou L, Styblo M, Walton F, Jing Y, Weinberg R, Chen Z, Waxman S.Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells.Cancer Res. 2003 Apr 15;63(8):1853-9.

24.    Gu BW, Xiong H, Zhou Y, Chen B, Wang L, Dong S, Yu ZY, Lu LF, Zhong M, Yin HF, Zhu GF, Huang W, Ren SX, Gallagher RE, Waxman S, Chen GQ, Wang ZG, Chen Z, Fu G, Chen SJ.Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy.Proc Natl Acad Sci U S A. 2002 May 28;99(11):7640-5. PMID: 12032336 [PubMed - indexed for MEDLINE]

25.    Jing Y, Wang L, Xia L, Chen GQ, Chen Z, Miller WH, Waxman S.Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo.Blood. 2001 Jan 1;97(1):264-9.

26.    Jia P, Chen G , Huang X, Cai X, Yang J, Wang L, Zhou Y, Shen Y, Zhou L, Yu Y, Chen S, Zhang X, Wang Z.Arsenic trioxide induces multiple myeloma cell apoptosis via disruption of mitochondrial transmembrane potentials and activation of caspase-3. Chin Med J (Engl). 2001 Jan;114(1):19-24. PMID: 11779429 [PubMed - indexed for MEDLINE]

27.    Cai X, Shen YL, Zhu Q, Jia PM, Yu Y, Zhou L, Huang Y, Zhang JW, Xiong SM, Chen SJ, Wang ZY, Chen Z, Chen GQ. Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia.Leukemia. 2000 Feb;14(2):262-70.PMID: 10673743 [PubMed - indexed for MEDLINE]

28.    Niu C, Yan H, Yu T, Sun HP, Liu JX, Li XS, Wu W, Zhang FQ, Chen Y, Zhou L, Li JM, Zeng XY, Yang RR, Yuan MM, Ren MY, Gu FY, Cao Q, Gu BW, Su XY, Chen GQ, Xiong SM, Zhang TD, Waxman S, Wang ZY, Chen Z, Hu J, Shen ZX, Chen SJ.Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients.Blood. 1999 Nov 15;94(10):3315-24.PMID: 10552940 [PubMed - indexed for MEDLINE]

29.    Zhu J, Guo WM, Yao YY, Zhao WL, Pan L, Cai X, Ju B, Sun GL, Wang HL, Chen SJ, Chen GQ, Caen J, Chen Z, Wang ZY.Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents.Leukemia. 1999 Jul;13(7):1062-70.PMID: 10400422 [PubMed - indexed for MEDLINE]

30.    Zhu XH, Shen YL, Jing YK, Cai X, Jia PM, Huang Y, Tang W, Shi GY, Sun YP, Dai J, Wang ZY, Chen SJ, Zhang TD, Waxman S, Chen Z, Chen GQ. Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations.J Natl Cancer Inst. 1999 May 5;91(9):772-8.PMID: 10328107 [PubMed - indexed for MEDLINE]

31.    Ni J, Chen G , Shen Z, Li X, Liu H, Huang Y, Fang Z, Chen S, Wang Z, Chen Z.Pharmacokinetics of intravenous arsenic trioxide in the treatment of acute promyelocytic leukemia.Chin Med J (Engl). 1998 Dec;111(12):1107-10.

32.    Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Qiu QY, Zhu J, Tang W, Sun GL, Yang KQ, Chen Y, Zhou L, Fang ZW, Wang YT, Ma J, Zhang P, Zhang TD, Chen SJ, Chen Z, Wang ZY.Use of arsenic trioxide (As₂O₃) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients.Blood. 1997 May 1;89(9):3354-60. PMID: 9129042 [PubMed - indexed for MEDLINE]

33.    Chen GQ, Shi XG, Tang W, Xiong SM, Zhu J, Cai X, Han ZG, Ni JH, Shi GY, Jia PM, Liu MM, He KL, Niu C, Ma J, Zhang P, Zhang TD, Paul P, Naoe T, Kitamura K, Miller W, Waxman S, Wang ZY, de The H, Chen SJ, Chen Z.Use of arsenic trioxide (As₂O₃) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells.Blood. 1997 May 1;89(9):3345-53.PMID: 9129041 [PubMed - indexed for MEDLINE]

34.    Chen GQ, Zhu J, Shi XG, Ni JH, Zhong HJ, Si GY, Jin XL, Tang W, Li XS, Xong SM, Shen ZX, Sun GL, Ma J, Zhang P, Zhang TD, Gazin C, Naoe T, Chen SJ, Wang ZY, Chen Z.In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As₂O₃) in the treatment of acute promyelocytic leukemia: As₂O₃ induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins.Blood. 1996 Aug 1;88(3):1052-61.PMID: 8704214 [PubMed - indexed for MEDLINE]

35.    Chen GQ, Shen ZX, Wu F, Han JY, Miao JM, Zhong HJ, Li XS, Zhao JQ, Zhu J, Fang ZW, Chen SJ, Chen Z, Wang ZY.Pharmacokinetics and efficacy of low-dose all-trans retinoic acid in the treatment of acute promyelocytic leukemia.Leukemia. 1996 May;10(5):825-8.PMID: 8656678 [PubMed - indexed for MEDLINE]

Reviews and Books

36.    Chen GQ, Peng ZG, Liu W, Song LP, Jiang Y, Huang Y, Zhao Q.Hypoxia inducible factor-1alpha and leukemic cell differentiation.Sheng Li Xue Bao. 2006 Feb 25;58(1):5-13. PMID: 16489397 [PubMed - as supplied by publisher]

37.    Fang J, Chen SJ, Tong JH, Wang ZG, Chen GQ, Chen Z.Treatment of acute promyelocytic leukemia with ATRA and As2O3: a model of molecular target-based cancer therapy.Cancer Biol Ther. 2002 Nov-Dec;1(6):614-20. Review.PMID: 12642682 [PubMed - indexed for MEDLINE]

38.    Chen Z, Chen GQ, Shen ZX, Sun GL, Tong JH, Wang ZY, Chen SJ.Expanding the use of arsenic trioxide: leukemias and beyond.Semin Hematol. 2002 Apr;39(2 Suppl 1):22-6. Review. PMID: 12012319 [PubMed - indexed for MEDLINE]

39.    Zhao WL, Chen SJ, Shen Y, Xu L, Cai X, Chen GQ, Shen ZX, Chen Z, Wang ZY.Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical and basic studies.Leuk Lymphoma. 2001 Nov-Dec;42(6):1265-73. Review. PMID: 11911407 [PubMed - indexed for MEDLINE]

40.    Zhang TD, Chen GQ, Wang ZG, Wang ZY, Chen SJ, Chen Z.Arsenic trioxide, a therapeutic agent for APL.Oncogene. 2001 Oct 29;20(49):7146-53. Review. PMID: 11704843 [PubMed - indexed for MEDLINE]

41.    Chen Z, Chen GQ, Shen ZX, Sun GL, Tong JH, Wang ZY, Chen SJ.Expanding the use of arsenic trioxide: leukemias and beyond.Semin Hematol. 2002 Apr;39(2 Suppl 1):22-6. Review.PMID: 12012319 [PubMed - indexed for MEDLINE]

42.    Chen Z, Chen GQ, Shen ZX, Chen SJ, Wang ZY.Treatment of acute promyelocytic leukemia with arsenic compounds: in vitro and in vivo studies.Semin Hematol. 2001 Jan;38(1):26-36. Review.PMID: 11172537 [PubMed - indexed for MEDLINE]