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1978-1982年
南京大学化学系,获理学学士学位。
1982-1988年
中科院上海生物化学研究所研究生,获理学博士学位。
1989-1991年
日本理化学研究所博士后研究。
1992-1993年
以访问学者身份赴日本理化学研究所进行合作研究。
1995年
以访问学者身份在法国Strasbourg的遗传与分子细胞生物学研究所(IGBMC)进行合作研究。
1996-1997年
以访问学者身份在德国Geottingen之马普生物物理化学研究所(Max-Planck
Institute for Biophysical Chemistry)进行合作研究。
2000年
以访问教授身份赴日本熊本大学进行合作研究。
2003年
以访问教授身份赴日本大阪大学进行合作研究。
中国生物化学与分子生物学学会副理事长兼秘书长;中国细胞生物学学会理事;上海生物化学与分子生物学学会理事长;中国神经科学学会神经化学专业委员会主任委员。《生理学报》、《J.
Mol. Cell Biol.》编委和《Neuroscience
Bulletin》常务编委。
研究方向
大脑发育与脑功能的分子和细胞机制。大脑是生物体内最复杂的器官之一,而这一复杂系统是由胚胎发育早期的神经干细胞发育分化而来的。因此,研究神经干细胞发生和神经元发育分化的分子机制,将有助于加深人们对大脑是如何形成的这一问题的认识。同时,在分子水平上研究脑重要功能相关基因,将有助于加深人们对大脑是如何工作的这一问题的认识。
目前从事的主要研究工作有:
1. 以胚胎干细胞(ES)和多潜能P19细胞的体外神经分化为模型,研究多潜能干细胞神经命运决定过程中FGF、BMP和WNT信号通路间的调控网络。
2.
以鸡胚神经发育为模型,研究在神经发生过程中神经元和胶质细胞命运决定的分子机制。
3.
小鼠巢蛋白基因表达调控的分子机制。
4. 脑功能及神经系统疾病相关基因的筛选、鉴定及功能研究。
近期发表的研究论文:
1.
X. Gao,
W. Bian, J. Yang, K. Tang, H. Kitani, T. Atsumi, N. Jing*. A role of N-cadherin in neuronal differentiation of
embryonic carcinoma P19 cells. Biochem.
Biophy. Res. Commun., 2001, 284:1098-1103.
2.
Tang K,
Yang J, Gao X, Wang C, Liu L, Kitani H, Atsumi T, Jing N*.Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19
cells. Biochem.
Biophys. Res. Commun.,
2002, 293:167-73.
3.
Lin W,
Furthauer M, Thisse B, Thisse C, Jing
N, Ang SL. Cloning of the mouse Sef gene and comparative analysis of its expression
with Fgf8 and Spry2 during embryogenesis.
Mech. Dev., 2002,
113:163-168.
4.
Tang K,
Wang C, Shen C, Sheng S, Ravid R, Jing
N*. Identification of a novel alternative splicing isoform of human amyloid
precursor protein gene, APP639. Eur.
J. Neurosci.,
2003, 18:102-108.
5.
Shinya Tanaka, Yusuke Kamachi, Aki Tanouchi, Hiroshi Hamada, Naihe
Jing and Hisato Kondoh. Interplay of SOX and POU factors in
regulation of the nestin gene in neural primordial cells. Mol.
Cell. Biol., 2004, 24:8834-8846.
6.
Qiuling Hou, Xiang Gao, Xuehan Zhang, Linwei Kong, Xinming Wang,
Wei Bian, Yanyang Tu,
Meilei Jin
, Guoping Zhao, Baoming Li, Naihe Jing* and Lei Yu. SNAP
-25 in
hippocampal CA1 region is involved in memory consolidation. Eur.
J. Neurosci., 2004, 20:1593-1603. (Also see: Eur. J.
Neurosci., 2004, 20:2489).
7.
Ye Yan, Wei Bain, Zhiqin Xie, Xinmin Cao, Isabelle Le Roux,
Francois Guillemot, Naihe Jing*.
Stat3 signaling is present and active during development of the
central nervous system and eye of vertebrates. Dev. Dyn.,
2004, 231:248–257.
8.
Leping Cheng, Zhigang Jin, Li Liu, Ye Yan, Tingting Li, Xueliang
Zhu, Naihe Jing*.
Characterization and promoter analysis of the mouse nestin gene. FEBS
Lett.,
2004, 565:195–202.
9.
Jie An, Quan Yuan, Chen Wang, Li Liu, Ke Tang, Hongyu Tian, Naihe
Jing* and Fukun
Zhao. Differential display of proteins involved in the neural
differentiation of mouse embryonic carcinoma P19 cells by
comparative proteomic analysis. Proteomics,
2005, 5:1656–1668.
10.
Lirong
Diao, Bianhong Zhang, Junkai Fan, Xiang Gao, Shaogang Sun, Kai
Yang, Dan Xin, Naihe
Jing, Yunqi Geng and Chen Wang. Herpes virus proteins
ICP0 and BICP0 can activate NF-κB by catalyzing IκB-ubiquitination.
Cell. Signal., 2005, 17:217–229.
11.
Hideki
Kanaya, Ryu Takeya, Kosei Takeuchi, Norinobu Watanabe, Naihe
Jing and
Hideki Sumimoto
. Fhos2, a novel formin-related actin-organizing protein, probably
associates with the nestin intermediate filament. Genes to
Cells,
2005, 10:665-678.
12.
Xue-Han
Zhang ,Hui Zhang, Yanyang Tu, Xiang Gao, Changfu Zhou,
Meilei Jin
, Guoping Zhao, Naihe
Jing*,
Bao-Ming Li
,Lei Yu. Identification of a novel protein for memory
regulation in the hippocampus. Biochem. Biophy. Res. Commun.,
2005, 334:418-424.
13.
Xidao Wang, Yuqiu Zhang, Lingwei Kong, Zhiqin Xie, Zhixin Lin, Ning
Guo, Judith A. Strong, Johanna T. A. Meij, Zhiqi Zhao, Naihe
Jing* and Lei Yu. RSEP1 is a novel gene with
functional involvement in neuropathic pain behaviour. Eur.
J. Neurosci., 2005,
22:1090–1096.
14.
Wei
Lin, Naihe Jing,
M. Albert Basson, Andre’e Dierich, Jonathan Licht, and Siew-Lan
Ang. Synergistic
Activity of Sef and Sprouty Proteins in Regulating the Expression
of Gbx
2 in
the Mid-Hindbrain Region. Genesis,
2005, 41:110-115.
15.
Leiming
Wang,
Ye Yan
, Liangjian Zou, Naihe Jing*, Zhiyun Xu. Moderate hypothermia prevents neural cell
apoptosis following spinal cord ischemia in rabbits. Cell
Research, 2005,
15:387-393.
16.
M.
Jin, X.-M. Wang, Y. Tu, X.-H. Zhang, X. Gao, N. Guo, Z. Xie, G.
Zhao, N. Jing*,
B.-M. Li and L. Yu. The negative cell cycle regulator, TOB
(Transducer of ErbB-2), is a multifunction protein involved in
hippocampus-dependent learning and memory. Neuroscience,
2005, 131:647–659.
17.
Weijun Pan, Yingying Jia, Jiyong Wang, Donglei Tao, Xiaoqing Gan,
Leonidas Tsiokas, Naihe
Jing, Dianqing Wu, and Lin Li. b-Catenin regulates myogenesis by relieving I-mfa-mediated
suppression of myogenic regulatory factors in P19 cells. Proc. Natl. Acad. Sci. UAS,
2005, 102:17378–17383.
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