and Chemical Research, Japan.  There Dr. Jing helped to set up a primary culture system of neuroepithelial cells of day 10 mouse embryos.  Then he found a human teratocarcinoma cell line, PA-1, secreted the growth factors related to EGF and IGF-I.  After coming back to Shanghai in 1991, he have set up his own research group to continue the work of developmental neurobiology.  Dr. Jing’s research interest is the molecular mechanism of the development of central nervous system (CNS) in mouse.  After 4 years hard work, their group has finally cloned mouse nestin gene, an intermediate filament protein expressed specifically in neural precursor cell during CNS development.  By immunochemistry and in situ hybridization, they found this gene’s specific expression pattern during mouse eye and lens development.   Using mouse embryonic carcinoma P19 cell’s neuronal differentiation as an in vitro model system, they found that stable-transfected cell lines which are over-express Wnt-1 or N-cadherin gene could differentiate into neuron-like cells without RA induction.  Besides the works mentioned above, Dr. Jing has worked as a visiting scientist in Dr. Francois Guillemot's laboratory in Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), France with the project: Isolation of genes differentially expressed in wild-type and HES1 mutant mouse embryos by Representational Difference Analysis of cDNA in 1995.  From 1996-1997, as a visiting scholar with sabbatical leave, he was in Prof. Peter Gruss's lab in Max-Planck Institute of Biophysical Chemistry, Goettingen, Germany, mainly working on eye specific cis-element analysis of mouse Six3 gene using transgenic technology.  In 2000, Dr. Jing also worked as the visiting professor in Kumamoto University, Japan for three months.

Recent publications:　

1.      X. Gao, W. Bian, J. Yang, K. Tang, H. Kitani, T. Atsumi, N. Jing*. A role of N-cadherin in neuronal differentiation of embryonic carcinoma P19 cells. Biochem. Biophy. Res. Commun., 2001, 284:1098-1103.

2.      Tang K, Yang J, Gao X, Wang C, Liu L, Kitani H, Atsumi T, Jing N*.Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19 cells. Biochem. Biophys. Res. Commun., 2002, 293:167-73.

3.      Lin W, Furthauer M, Thisse B, Thisse C, Jing N, Ang SL. Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis. Mech. Dev., 2002, 113:163-168.

4.      Tang K, Wang C, Shen C, Sheng S, Ravid R, Jing N*. Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639. Eur. J. Neurosci., 2003, 18:102-108.

5.      Shinya Tanaka, Yusuke Kamachi, Aki Tanouchi, Hiroshi Hamada, Naihe Jing and Hisato Kondoh. Interplay of SOX and POU factors in regulation of the nestin gene in neural primordial cells. Mol. Cell. Biol., 2004, 24:8834-8846.

6.      Qiuling Hou, Xiang Gao, Xuehan Zhang, Linwei Kong, Xinming Wang, Wei Bian, Yanyang Tu, Meilei Jin , Guoping Zhao, Baoming Li, Naihe Jing* and Lei Yu. SNAP -25 in hippocampal CA1 region is involved in memory consolidation. Eur. J. Neurosci., 2004, 20:1593-1603. (Also see: Eur. J. Neurosci., 2004, 20:2489).

7.      Ye Yan, Wei Bain, Zhiqin Xie, Xinmin Cao, Isabelle Le Roux, Francois Guillemot, Naihe Jing*. Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates. Dev. Dyn., 2004, 231:248–257.

8.      Leping Cheng, Zhigang Jin, Li Liu, Ye Yan, Tingting Li, Xueliang Zhu, Naihe Jing*. Characterization and promoter analysis of the mouse nestin gene. FEBS Lett., 2004, 565:195–202.

9.      Jie An, Quan Yuan, Chen Wang, Li Liu, Ke Tang, Hongyu Tian, Naihe Jing* and Fukun Zhao. Differential display of proteins involved in the neural differentiation of mouse embryonic carcinoma P19 cells by comparative proteomic analysis. Proteomics, 2005, 5:1656–1668.

10.  Lirong Diao, Bianhong Zhang, Junkai Fan, Xiang Gao, Shaogang Sun, Kai Yang, Dan Xin, Naihe Jing, Yunqi Geng and Chen Wang. Herpes virus proteins ICP0 and BICP0 can activate NF-κB by catalyzing IκB-ubiquitination. Cell. Signal., 2005, 17:217–229.

11.  Hideki Kanaya, Ryu Takeya, Kosei Takeuchi, Norinobu Watanabe, Naihe Jing and Hideki Sumimoto . Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament. Genes to Cells, 2005, 10:665-678.

12.  Xue-Han Zhang ,Hui Zhang, Yanyang Tu, Xiang Gao, Changfu Zhou, Meilei Jin , Guoping Zhao, Naihe Jing*, Bao-Ming Li ,Lei Yu. Identification of a novel protein for memory regulation in the hippocampus. Biochem. Biophy. Res. Commun., 2005, 334:418-424.

13.  Xidao Wang, Yuqiu Zhang, Lingwei Kong, Zhiqin Xie, Zhixin Lin, Ning Guo, Judith A. Strong, Johanna T. A. Meij, Zhiqi Zhao, Naihe Jing* and Lei Yu. RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour. Eur. J. Neurosci., 2005, 22:1090–1096.

14.  Wei Lin, Naihe Jing, M. Albert Basson, Andre’e Dierich, Jonathan Licht, and Siew-Lan Ang. Synergistic Activity of Sef and Sprouty Proteins in Regulating the Expression of Gbx 2 in the Mid-Hindbrain Region. Genesis, 2005, 41:110-115.

15.  Leiming Wang, Ye Yan , Liangjian Zou, Naihe Jing*, Zhiyun Xu. Moderate hypothermia prevents neural cell apoptosis following spinal cord ischemia in rabbits. Cell Research, 2005, 15:387-393.

16.  M. Jin, X.-M. Wang, Y. Tu, X.-H. Zhang, X. Gao, N. Guo, Z. Xie, G. Zhao, N. Jing*, B.-M. Li and L. Yu. The negative cell cycle regulator, TOB (Transducer of ErbB-2), is a multifunction protein involved in hippocampus-dependent learning and memory. Neuroscience, 2005, 131:647–659.

17.  Weijun Pan, Yingying Jia, Jiyong Wang, Donglei Tao, Xiaoqing Gan, Leonidas Tsiokas, Naihe Jing, Dianqing Wu, and Lin Li. b-Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells. Proc. Natl. Acad. Sci. UAS, 2005, 102:17378–17383.