吉永华

     吉永华,男, 1955年生,1978年毕业于中国科技大学二系. 曾任中科院上海生理所研究员、研究组负责人、博导、兼任研究生处负责人、所学术委员会副主任、所科研计划处处长。曾多次出访日本岗崎国立生理学研究所并在法国爱克斯-马赛第2大学北区医学院学习进修一年。94年获日本静冈县立大学药学博士学位。97年受聘JSPS特别研究员出访日本工作一年。主要从事神经药理与毒理学的研究。迄今已发表学术合作研究论文50余篇(其中被国际期刊SCI收录的论文共33), 学术综述19. 94年获首届上海市自然科学牡丹奖, 95年被上海市科委审定为上海市首批优秀学科带头人之一,96年获第3届国家自然科学杰出青年基金的资助。98年获首届明治乳业生命科学奖。自95年以来已负责培养毕业了一名博士生、三名硕士生和八名本科生的学位毕业论文。

Selected Publications:

[1] Zhao Y.J., Zhang S.X. & Ji Y.H. (1980) Isolation and recombination of ATPase complex F1X from the mitochondria of swine heart, Prog.Biochem.Biophys., 3:61-64 (In Chinese)

[2] Ji Y.H et al. (1983) Isolation and identification of cardiotoxic and neurotoxic components from venom of Bungarus fasciatus Schneider, Acta Herpetologica Sinica, 2(2):69-74 (In Chinese)

[3] Ji Y.H & Hsu K. (1983) Isolation and purification of mammal neurotoxins from the venom of the scorpion Buthus martensi Karsch, Acta Biochem.Biophys.Sinica, 15(6): 517-521 (In Chinese)

[4] Ji Y.H, Hsu K. & Gu Z.W. Partial amino acid sequence of mammalian neurotoxin I from the venom of the scorpion Buthus martensi Karsch, Kexue Tongbao, 1984, 29(19):1200-1202 (In Chinese), Chinese Sci. Bull., 1985, 30(6):813-816 (English version)

[5] Ji Y.H & Hsu K. (1986) Biochemical study on scorpion anti-mammal neurotoxins, Prog.Physiol.Sci., 17(3):234-239 (In Chinese)

[6] Shin Y.L., Ji Y.H & Wang W.P. (1987) Effects of the extract from the centipede (Scolopendra subspinipes mutilans, Lkoch) on heart and uterus contraction and on blood glueose level, Zoological Res., 8(1):68,76 (In Chinese)

[7] Ji Y.H, Shin Y.L. & Hsu K. (1988) Scorpion venoms and scorpion neurotoxins, The Study and Practice of Natural Toxins, Science Press, Beijing, China, pp. 145-158 (In Chinese)

[8] Ji Y.H, Kimura Y., Hsu K. & Terakawa S. (1988) Purification and the partial amino acid sequence of an insect neurotoxin from the venom of scorpion Buthus martensi Karsch, Comp.Biochem.Physiol., 90C (1):237-240

[9] Kimura Y., Terakawa S., Hsu K. & Ji Y.H. (1988) Ionic composition of the haemolymph of a Chinese scorpion Buthus martensi Karsch, Comp.Biochem.Physiol., 91A (2):323-325

[10] Terakawa S., Kimura Y., Hsu K. & Ji Y.H. (1989) Lack of effect of a neurotoxin from the scorpion Buthus martensi Karsch on nerve fibers of this scorpion, Toxicon, 27(5):569-578

[11] Zhang Y., Liu W.Y., Ji Y.H & Hsu K. (1989) Study on phosphomonoesterase, RNase and Dnase in spider (Lycosa singoriensis) venom, Zoological Res., 10(2):139-142 (In Chinese)

[12] Hsu K., Ji Y.H & Qu X.M. (1989) Identification and purification of an antibacterial polypeptide from the venom of spider Lycosa singoriensis, Acta Zoological Sinica, 35(3):300-305 (In Chinese)

[13] Luo G.X., Zhang L.Q., Gu Z.W., Ji Y.H & Hsu K. (1989) Partial sequence of toxin II of Buthus martensi Karsch active on mammals, Prog.Biochem. Biophys., 16(1):46-47 (In Chinese)

[14] Ji Y.H & Lu L.F. (1990)  Molecular structure and pharmacological effect of scorpion neurotoxins, Chemistry of life, 10(1):1-3 (In Chinese)

[15] Ji Y.H. (1990) Biochemical study on scorpion anti-insect neurotoxins, Prog.Biochem. Biophys., 17(2):100-105 (In Chinese)

[16] Ji Y.H & Hsu K. (1991) Surveying on heat resistance and polymeric property of antibacterial substances in the venom of spider Lycosa singoriensis, Acta Zoological Sinica, 37:258-262 (In Chinese)

[17] Zhao W.Q., Ji Y.H, Hsu K., Chen Z.G., Sha H.F. & Bao G.L. (1991) Cytopathic action of spider (Lycosa singoriensis) venom and it’s fractions on the cultured human lung adenocarcinoma cells (SPA-A1), Zoological Res., 12(1):67-71 (In Chinese)

[18] Zhu D.Y. & Ji,Y.H.* (1992) Classification of alpha type scorpion neurotoxins on the basis of their structure features, Chin. J Pharm. Toxicol., 6(2):91-96 (English version)

[19] Ji Y.H,* Mansuelle P., Hsu K., Granier C., Kopeyan C., Terakawa S. & Rochat H., Amino acid sequence of an excitatory insect-selective toxin (BmK IT) from venom of the scorpion Buthus martensi Karsch, Sci. China, 1993, 23(1):46-52 (In Chinese);  1994, 37(1):42-49 (English version)

[20] Ji Y.H,* Lu L.F., Zhu D.Y., Hsu K., Kajiura H. & Terakawa S. HPLC purification and partial amino acid sequence of an alpha type anti-insect neurotoxin from venom of scorpion Buthus martensi Karsch, Chin. Sci. Bull., 1993, 38(5):465-467 (In Chinese); 1993, 38(14):1211-1215 (English version)

[21] Ji Y.H,* Hattore H., Ksu K. & Terakawa S., Molecular characteristics of four new depressant insect neurotoxins purified from venom of Buthus martensi Karsch by HPLC, Sci. China, 1993, 23(9):923-930 (In Chinese); 1994, 37(8):954-963 (English version)

[22] Marchot P., Khelif A., Ji Y.H, Mansuelle P. & Bougis P.E. (1993) Binding of 125I-Fasciculin to rat brain acetylcholinesterase: The complx still binds diisopropyl fluorophosphate, J. Biol. Chem., 268 (17): 12458-12467

[23] Ji Y.H.,* Lu L.F., Hsu K., Hattori H. & Terakawa S. Purification and partial amino acid sequence of a novel presynaptic toxin and a cytotoxin from venom of the pit veper Agkistrodon blomhoffii brevicadus, Sci. China, 1993, 23(12):1259-1266 (In Chinese);  1995, 38(2):169-178 (In English)

[24] Ji Y.H.,* Terakawa S. & Hsu K. (1994) Primary structure of a depressant insect-selective toxin from venom of scorpion Buthus martensi Karsch, Chin. Sci. Bull., 39(3):269-272 (In Chinese); 39(11): 945-949 (English version)

[25] Hsu K. & Ji Y.H. (1994) b2 -agkistrodotoxin: an presynaptic toxin purified from the venom of the pit veper, Chin. J. Snakology, 3(1):26-29, (In Chinese)

[26] Ji Y.H.* & Liu Y. (1995)  Potassium channel-blocking peptides from scorpion, Chin. Bull. Life Sci. 7(5): 1-5,10 (In Chinese)

[27] Liu Y. & Ji Y.H,* (1996) Research advance on molecular biology of scorpion neurotoxins, Chin. Bull. Life Sci., 8(2): 34-37 (In Chinese).

[28] Ji Y.H.,* Terakawa S. & Hsu K. (1994) Primary structure of a depressant insect-selective toxin from venom of scorpion Buthus martensi Karsch, Chin. Sci. Bull., 39(3):269-272 (In Chinese);  39(11): 945- 949 (English version)

[29] Ji Y.H.,* Mansuelle P., Terakawa S., Kopeyan C., Yanaihara N., Xu K. & Rochat H. (1996) Two neurotoxins (BmK I and BmK II) from the venom of scorpion Buthus martensi Karsch: purification, amino acid sequences and assessment of specific activity, Toxicon, 34(9):987-1001

[30] Ji Y.H.,* Xu K., Kawano S., Hirayama Y., Hiraroka M., Kuniyasu A. & Nakayama H. An new scorpion polypeptide enhances the binding of radiolabeled-ryanodine on ryanodine-receptor in sarcoplasmic reticulum of rabbit skeletal-muscle, Chin. Sci. Bull., 1996,22:2077-2080 (In Chinese);  1997, 42(2):147-150 (English version)

[31] Liu Y., Ren H.M., Ji Y.H.,* Ohishi T., Hoshino M., Mochizuki T. & Yanaihara N. (1996) Purification and the partial amino acid sequence of an new activator homologue of ryanodine receptor on skeletal muscle, Biomedical Res., 17(6): 451-455

[32] Ji Y.H.* & Zhao J. (1996) Scorpion toxins could be used as a “scaffold” to build new peptide drug molecules. Chemistry of Life, 16(4):32-34

[33] Ji Y.H.* & Zhao J. (1996) How far the virus containning the gene(s) of insect-selective neurotoxic peptide(s) from scorpion venom to reach to bio pesticide ? Chin.Bull.Life Sci.8(3):37-39 (In Chinese)

[34] Ji Y.H,* Liu Y., Xu K., Ohishi T., Hoshino M., Mochizuki T. & Yanaihara N. (1997) Amino acid sequence of BmK AS, an novel polypeptide activator of ryanodine receptor on skeletal muscle, Chin. Sci. Bull., 9:976-980  (In Chinese);  11:952-956 (English version)

[35] Ren H.M. & Ji Y.H.* (1997) Observation of polymerism and isomerism of b-agkistrodotoxin. Prog.Biochem. Biophys., 6:521-525 (In Chinese)

[36]Wu H.M., Huang X.L., Ji Y.H. & Wang D.C. (1997) Two-dimensional 1H nuclear magnetic resonance study on neurotoxin BmK I----Sequential resonance assignments and secondary structure, Prog. Natu Sci. 6:741-747 (In Chinese); 3:366-370 (English version)

[37] Ji Y.H.,* Huang H.Y., Zhou C.W., Liu Y., Hoshino M., Mochizuki T. & Yanaihara N. (1997) BmK AS, an active scorpion polypeptide, enhances [3H]noradrenal release from rat hippocampal slices. Biomedical Res. 3:257-260

[38] Liu Y., Zhao Q., Ji Y.H.*, Oiki S., Hazama A., Morishima S., Sabirov R., Zhou S.S., Hayashi S., Tsumura T., Ito T., Furuya K & Okada Y (1997) The venom of Scorpion B.martensi Selectively Inhibits Transient Outward K+ Currents in Neonatal Rat Ventricular Cells and Kv+ Channel currents in NG108-15 Cells. Biomedical Res. 5:383-388

[39] Ohishi T., Iguchi K., Mochizuki T., Hoshino M., Ji Y.H. & Yanaihara N (1997) Isolation and characterization of neuropeptide Y from the brain of a Chinese snake, Dinodon rufozonatus. Biomedical Res. 18:87-93

[40] Ohishi T., Nakajima H., Iguchi K., Mochizuki T., Hoshino M., Ji Y.H. & Yanaihara N. (1997) Isolation and sequence determination of snake (Dinodon rufozonatus Cantor) and yellow fin tuna (Thunnus albacares) NPYs. Peptide Chemistry 1996, pp. 153-156

[41] Ji Y.H.,* Li Y.J., Song B.L., Yamaki T., Mochizuki T., Hoshino M & Yanaihara N (1997) Covalent structures of BmK AS and BmK AS-1, two novel neurotoxic polypeptides purified from Chinese scorpion Buthus martensi karsch. Advances in Comparative Endocrinology, Tome 1: 629-633

[42] Ji Y.H.,* (1998) A reform on :Brain Research” occuring in Japan . World Sci-Tech R & D., 20(1):59-60  (In Chinese)

[43] Ji Y.H.*, Li Y.J., Zhang J.W., Song B.L., Yamaki T., Mochizuki T., Hoshino M., Yanaihara N. (1999) Covalent structures of BmK AS and BmK AS-1, two novel bioactive polypeptides purified from Chinese scorpion Buthus martensi Karsch. Toxicon 37:519-536  [IF=1.248]

[44] Kuniyasu A., Kawano S., Hirayama Y., Ji Y.H., Xu K., Ohkura M., Furukawa K., Ohizumi Y., Hiraoka M., Nakayama H (1999) A new scorpion toxin (BmK-PL) stimulates Ca2+-release channel activity of the skeletal-muscle ryanodine receptor by an indirect mechanism. Biochem J. 339: 343-350                                                [IF=4.35]

[45] Tong Q.C., Zhang Y., Zhou Z.N. & Ji Y.H.* (1999) The characterization and blocking effects on Ito of rat ventricular myocyte of new minipeptides from Buthus martensi Karsch. Acta Biochimica et Biophysica Sinica 31(3): 347-349  (In Chinese)             [IF=0.153]

[46] Li Y.J., Liu Y. & Ji Y.H. * (1999) Characteristics of BmK AS binding to rat brain and cockroach nervecord synaptosomes Acta Biochimica et Biophysica Sinica 31(5): 604-606  [IF=0.153]

[47] Ji Y.H.* (1999) Scorpion neurotoxic polypeptides and their ion channel targets. Fudan Lectures in Neurobiology, XV:91-104 (in Chinese)

[48] Jia L.Y. & Ji Y.H.* (1999) Subtypes and functions of voltage-gated Na+ channel, Prog.Physiol.Sci., 30(2):107-112 (In Chinese)

[49]Tan Z.Y. & Ji Y.H.* (1999) Voltage-gated Na+ channel in nociceptive afferents of DRG neurons. Prog.Physiol.Sci., 30(3):198-202 (In Chinese)

[50] Li Y.J. & Ji Y.H.* (1999) Channelopathy of voltage-gated sodium channel. Prog.Physiol.Sci., 30(4):297-302 (In Chinese)

[51] Tong Q.C. & Ji Y.H.* (1999) A new type of antimicrobial peptide—defensin. Chin. Bull. Life Sci. 11(3):117-120  (In Chinese)

[52] Li Y.J. & Ji Y.H.* (1999) A new investigation of toxicological mechanism of mercury and arsenic.Shanghai J. Traditional Chin. Medicine, 3:40-42 (In Chinese)

[53] Jia L.Y., Zhang J.W. & Ji Y.H.* (1999) Biosensor binding assay of BmK AS-1, a novel Na+ channel-blocking scorpion ligand on rat brain synaptosomes Neuroreport 10(16): 3359-3362     [IF=2.682]

[54] Jia L.Y., Xie H.F. & Ji Y.H.* (2000) Characterization of four distinct monoclonal antibodies specific to BmK As-1, a novel scorpion bioactive polypeptide. Toxicon 38: 605-617    [IF=1.445]

[55] Li Y.J., Jia L.Y. & Ji Y.H.* (2000) Kinetic distributioin of long-chain scorpion neurotoxins in mice. Chin J Pharm. Toxic 14(2): 116-120 (English version)

[56] Huang X.L., Xiao H., Tang Y., Yu X.Y., Liu X.J., Ji Y.H. & Wang H.L. (2000) Effects of the polypeptide of scorpion venom: BmK VII, BmK XIII on spontaneous active potential of the central nerve of periplaneta americana, Acta Universitatis Medicinalis Nanjing, 20(3):181-185 (In Chinese)

[57] Ji Y.H.* & Tong Q.C. (2000) Advances on the study of several kinds of K+ channels. Chin. Bull. Life Sci.,12(2):63-67  (In Chinese)

[58] Tong Q.C., Zhang Y., Zhou Z.N. & Ji Y.H.* (2000) BmP02, one short-chain scorpion peptide selectively blocks transient outward K+ channel of adult rat ventricular myocyte. Regulatory Peptides 9(1-3): 85-92   [IF=2.634]

[59] Li Y.J., Liu Y. & Ji Y.H.* (2000) A new scorpion neurotoxin BmK AS binds to distinct receptor sites of voltage-gated sodium channel on rat brain and insect synaptosomes. J Neurosci Res. 61(5): 541-548   

       [IF=3.207]

[60] Ye J.G., Tan Z.Y., Li Y.J., Yan Y.P., Li C., Chen J. & Ji Y.H.* (2000) Purification, cDNA cloning and functional assessment of BmK abT, a novel type neurotoxin from the scorpion species in the old world. FEBS Letters 479(3): 136-140       [IF=3.44]

[61] Xiao H., Mao X., Tan Z.Y., Shi Y., Zhang J.W., Chen J., Zhao Z.Q. & Ji Y.H. (2000) Effect of BmK AS-1, polypeptide purified from Chinese Buthus martensi Karsch (BmK) toxin, on rat cutaneous nociception. Chin. J. Pharm. Toxicol., 14(4):283-286  (In Chinese)

[62] Li Y.J. & Ji Y.H.* (2000) The binding of BmK I, an a-like scorpion toxin on rat brain and cockroach nerve cord synaptosomes, J Peptide Res. 2000, 56(4):195-200     [IF=1.439]

[63] Li Y.J., & Ji Y.H* (2000) The binding of BmK IT2, a depressant insect-selective scorpion toxin on the rat brain and cockroach nerve cord synaptosomes, Neurosci. Res., 38(3):257-264 [IF=1.807]

[64] Wang C.Y., Tan Z.Y., Zhao Z.Q. & Ji Y.H.* (2000) Antihyperalgesia effect of BmKIT2, a depressant insect-selective scorpion toxin in rat by peripheral administration, Brain Res. Bull., 53:335-338    [IF=1.758]

[65] Xu Y.Q., Wu J.H., Pei J.M., Shi Y.Y., Ji Y.H. & Tong,Q.C. (2000) Solution structure of BmP02, a new potassium channel blocker from the venom of Chinese scorpion Buthus martensi Karsch. Biochemistry 39(45):13669-13675       [IF=4.221]

[66] Tan Z.Y., Xiao H., Mao X., Wang C.Y., Zhao Z.Q. & Ji Y.H.* (2001) The inhibitory effects of BmK IT2, a scorpion neurotoxin on rat nociceptive flexion reflex and possible mechanism of modulating voltage-gated Na+ channels, Neuropharmacology 40(3):352-357  [IF=3.854]

[67] Tan Z.Y., Mao X., Xiao H., Zhao Z.Q. & Ji Y.H.* (2001) Buthus martensi Karsch agonist of skeletal-muscle RyR-1, a acorpion active polypeptide: antinociceptive effect on rat peripheral nervous system and spinal cord, and inhibition of voltage-gated Na+ currents in dorsal root ganglion neurons, Neurosci. Lett. 297(2):65-68     [IF=2.021]

[68] Ye J.G., Chen J., Zuo X.P. & Ji Y.H.* (2001) Cloning and characterization of cDNA sequences encoding two novel toxin precursors from the venom of Chinese scorpion Buthus martensi Karsch. Toxicon 39:1191-1194        [IF=1.575]

[69] Wu Y., Ji Y.H. & Shi Y.L.,* (2001)Sodium current in NG108-15 cell inhibited by scorpion BmK AS-1 and restored by its specific monocolonal antibodies. J. Natural Toxins 10: 193~198   [IF=0.894]

[70] Chen B., Wang C.Y. & Ji Y.H.* (2001) Scorpion BmK venom induces nociceptive response of rat by plantar injection. Neurotoxicol. Teratol. 23:675-679       [IF=2.288]

[71] Chen B. & Ji Y.H.* (2001) Structural classification and functional characterization of short-chain scorpion toxic peptides. Prog. Biochem. Biophys., 28(1):44-48 (in Chinese)

[72] Chen,B., Zuo,X.P., Wang,C.Y., Ji,Y.H.* (2002) Scorpion BmK venom induces plasma extravasation of rats by intraplantar injection. Toxicon 5:527-533            [IF=2.003]

[73] Zhang,X.Y.,Zhang,J.W.,Chen,B.,Bai,Z.T.,Shen,J., Ji,Y.H.* (2002) Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch, Brain Res. Bull. 58(1):27-31           [IF=2.283]

[74] Chen,B. & Ji,Y.H.* (2002) Antihyperalgesia effect of BmK AS , a scorpion toxin, in rat by intraplantar injection, Brain Res. 952(2):322-326                  [IF=2.409]

[75] Ji,Y.H.*  Wang,W.X., Wang,Q., Huang,Y.P. (2002) Biosensor binding of BmK abT, a unique neurotoxic polypeptide on mammal brain and insect sodium channels, Eur.J.Pharmacol. 454(1):25-30      [IF=2.342]

[76] Bai,Z.T.,Chen,B.,Zhang,X.Y., Fan,G.L., Ji,Y.H.* (2002) c-Fos expression in rat spinal cord induced by scorpion BmK venom via plantar subcutaneous injection, Neurosci. Res. 44:447-454      [IF=1.812]

[77] Sun H.Y. & Ji Y.H.* (2002) Structural characteristic of molecular inter-recognition between scorpion neurotoxins and insect sodium channel. Prog Nat Sci. 12(11) :9-11  (In Chinese)

[78] Zuo X.P. & Ji Y.H* (2002) Molecular mechanism of interactions between voltage-gated sodium channels and its modulators, Chin J Neurosci. 18(4): 736-739 (In Chinese)

[79] Ji Y.H.* Ye J.G., Wang W.X.,He L.L., Li Y.J.,Yan Y.P.,Tan Z.Y.,Chen J.,Zhou Z. (2003) Martentoxin, a distinct K+ channel-blocking ligand: purification, genomic organization, electrophysiological and biosensor binding characteristics. J. Neurochem. 84:325-335   [IF=4.969]

[80]Tan Z.Y.,Chen J.,Shun H.Y.,Ji Y.H.* (2003) Modulation of BmK AS, a Scorpion Neurotoxic Polypep-tide on Voltage-Gated Na+ Channels in B104 Neuronal Cell Line. Neurosci. Lett. 340:123-126    [IF=2.1]

[81] Sun H.Y., Zhu H.F., Ji Y.H.* (2003)  BmK I, an a-Like scorpion neurotoxin, specifically modulates isolated rat cardiac mechanical and electrical activity, Acta Physiological Sinica 55(5):530-534

[82] Bai Z.T., Zhang X.Y., Ji Y.H.* (2003) Fos expression in rat spinal cord induced by peripheral injecton of BmK I, a a-like scorpion neurotoxin. Toxicol. Appl. Pharm. 192:78-85 [IF=2.851]

[83] Zhang X.Y., Bai Z.T., Zhang J.W., Liu Y., Ji Y.H.* (2003) The suppression of BmK IT2 on nociceptive behavior and c-Fos expression in spinal cord induced by formalin. J. Neurosci. Res. 74:167-173  [IF=3.374]

[84] Chai Z.F. & Ji Y.H* (2003) The protein engineering of using scorpion toxin’s scaffold, Chin Bull Life Sci. 15(5):317-320  (In Chinese)

[85] Tan M. & Ji Y.H.* (2003) The allosteric modulating of neurotoxins on voltage-gated sodium channels. Chin J Neurosci. 19(4):264-267 (In Chinese)

[86]Tan Z.Y., Chen J., Feng X.H., Terakawa S., Ji Y.H.* (2004) Modulation of intracellular free Na+ con-centration by BmK AS, a scorpion toxin, in B104 neuronal cell line. Neuroreport, 15:13-16      [IF=2.503]

[87] Li Z.P., Zhang X.Y., Lu X., Ji Y.H.* (2004) Dynamic release of amino acid transmitter induced by valproate in PTZ-kindled epileptic rat hippocampus, Neurochem. Int., 44:263-270    [IF=3.261]

[88] Li Z.P, Zhang X.Y, Zhong M.K, Shi X.J, Ji Y.H* (2004)  The Neuropharmacokinetics of valproate in pentylenetetrazol-kindled conscious epileptic rat hippocampus, Biomedical Res.25(3):119-123       [IF=0.412]

[89] Qiao P., Zuo X.P., Chai Z.F. and JI Y.H.* (2004) The cDNA and Genomic DNA Organization of a Novel Toxin SHT-I from Spider Ornithoctonus huwena, Acta Bioch et Bioph Sin. 36(10):656-660  [IF=0.524]

[90] Zuo X.P., Ji Y.H* (2004) Molecular mechanism of scorpion neurotoxins acting on sodium channels: insight into their diverse selectivity, Mol Neurobiology. 30(3):265-278  [IF=4.516]

[91] Ji Y.H.* & Sun H.Y. (2004) Cardiac Excitation-Contraction Coupling Mediated by Ca2+. Acta Bio Exper Sin. 37(1):78-83 (In Chinese)

[92] Bai Z.T., Zhang X.Y., Ji Y.H.* (2004) Modulation and cellular/molecular mechanism of sodium channel-specific modulators on nociception /antinociception, Prog Chin Neurosci ()pp.266-272  (In Chinese)

[93] He H.Q., Zou X.P., Ji Y.H.* (2004) Voltage-gated sodium channel involved in clinic malady, Chin J Pharm. Clinic., 4(3):165-172 (In Chinese)

[94] Sun H.Y., Zhou Z.N., Ji Y.H.* (2005) The performance of voltage-gated Na+ channels in excitation-contraction coupling of rat ventricular myocytes determined by BmK I, an a-like scorpion neurotoxin, Toxicology in vitro, 19(2):183-190         [IF=1.642]

[95] Wang W.X., Ji Y.H.* (2005) Scorpion venom induces glioma cell apoptosis in vitro and inhibits glioma tumor growth in vivo, J Neuro-Oncology. 73:1-7       [IF=1.568]

[96] Chen J., Tan Z.Y., Zhao R., Feng X.H., Shi J., Ji Y.H*. (2005) The modulation effects of BmK I, an a-like scorpion neurotoxin, on voltage-gated Na+ currents in rat dorsal root ganglion neurons, Neurosci. Lett. 390:66-71       [IF=2.019]

[97] Zhao R.,Bai Z.T.,Chen J.,Liu T.,Tan Z.Y.,Chen B.,Zhang X.Y. Wang C. Y.,Ji Y.H.*  (2005) The nociceptive /antinociceptive effects of scorpion BmK toxins by specifically modulating sodium channels.Toxins et douleur, 139-148.

[98] Zhang X.Y., Zhao R., Ji Y.H.* (2005) Relationship between ion channelopathies and epilepsy, Chin J Neurmedicine, 4(1):86-91  (In Chinese)

[99] Bai Z.T., Zhao R., Zhang X.Y., Chen J., Liu T., Ji Y.H*. (2006) The epileptic seizures induced by BmK I, a modulator of sodium channels. Exp Neurol. 197(1):167-176.    [IF=3.369]

[100] Chai Z.F., Bai Z.T., Liu T., Pang X.Y., Ji Y.H*. (2006) The binding of BmK IT2 on mammal and insect sodium channels by surface plasmon resonance assay. Pharmacol. Res.(accepted), [IF=1.48]

[101] Chen J., Feng X.H., Shi J., Tan Z.Y., Bai Z.T., Liu T., Ji Y.H.* (2006) The anti-nociceptive effect of BmK AS, a scorpion active polypeptide and the possible mechanism on specifically modulating voltage-gated Na+ currents in primary afferent neurons. Peptides, (in revision)          [IF=2.511]

[102] Chen Y.N., Li K.C., Shang G.W., Liu D.N., Lu Z.M.m Zhang J.W., Ji Y.H., Gao G.D., Chen J.* (2006)  Effects of Bee venom peptidergic components on rat pain-related behaviors and inflammation, Neurosci., (accepted)    [IF=3.456]

[103] Bai Z.T., Liu T., Chai Z.F., Pang X.Y., Ji Y.H.* (2006) Pain responses induced by experimental scorpion BmK sting, Neurosci., (in revision)          [IF=3.456]