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Name
Huirong
Liu
M.D., Ph.D.
PRESENT
POSITION AND ADDRESS
Position
Professor
Department
of Physiology
Shanxi
Medical
University
Work
Address Department of Physiology
Shanxi
Medical
University
86
Xinjian South Road
,
Taiyuan
,
Shanxi
, 030001 P.R. China
Phone
( 351) 4135076
Fax (351) 4083014
E-Mail Address
liuhr2000@yahoo.com
PERSONAL INFORMATION
Date of
Birth: Aug.
26, 1959
Sex:
Female
Nationality:
P.R.
of
China
Birth
Place:
Shanxi
Province P.R.
of
China
EDUCATION:
Aug.
2001
to Aug.
2004
Department of Physiology
Thomas
Jefferson
University
Philadelphia
,
PA
,
U.S.A.
Postdoctoral
Fellow
Sep.
1996
to Jul. 1999
Department of Physiology
Shanxi
Medical
University
Taiyuan
,
P.R. China
Ph.D.
Sep. 1992
to Jul.
1995
Department of Immunology
Shanxi
Medical
College
Taiyuan
,
P.R. China
MA.
Med.
Mar.
1978
to Jan.
1981
Changzhi
Medical
College
Changzhi, P.R China
BA.
Med.
PROFESSIONAL INTERESTS:
Doctoral:
Relationship
of myocardial remodeling to the genesis of serum autoantibodies
to cardiac beta(1)-adrenoceptors and muscarinic type 2
acetylcholine receptors.
Postdoctoral:
a).
Role of Omi/HtrA
2 in
Apoptotic Cell Death After Myocardial Ischemia and Reperfusion.
b)
Apoptosis and myocardial ischemia-reperfusion injury.
c) Anti-Apoptosis Effects and
its Mechanisms of a Peroxisome Proliferator
activated Receptor-gamma Agonist in
Hypercholesterolemia.
d) Peroxynitrite in systemic
shock and post-ischemic tissue injury.
Current:
a) Relationship between autoantibodies against G-protein coupled receptors (i.e.,
b1
Adrenoceptor, b2
Adrenoceptor, b3
Adrenoceptor, a1
Adrenoceptor, Muscarinic type2 receptor) and cardiovascular
structure and their function.
b)
Investigation in mechanisms of myocyte cell death (i.e.,
necrosis
and
apoptosis) and vascular endothelial dysfunction,
role of apoptosis in extension of infarction during early and late phases of reperfusion after ischemia.
c) Illustration of signal transduction pathways involved in induction of
apoptotic cell death, such as Ca2+ overload,
expression in anti-apoptotic protein (XIAP) and pro-apoptotic proteins, p38, caspase activity, Omi/HtrA2 release
from mitochondria
as
well as cytochrome C in in vivo and in in vitro
model of ischemia and reperfusion.
Selected
publications£º
1.
HR.Liu,E.Gao,A.Hu,L.Tao,Y.Qu,P.Most,WJ.Koch,TA.Christoher,BL.Lopez,ES.Alnemri,A..
Role of Omi/HtrA
2 in
Apoptotic Cell Death After Myocardial Ischemia and Reperfusion. Circulation,
January,2005,111:90-96
2.
HR. Liu, L. Tao, E. Gao, BL. Lopez, TA. Christopher, RN. Willette, EH.
Ohlestein, TL.Yue, XL.Ma.
Anti-apoptosis effects of rosiglitazone in
hypercholesterolemic rabbits subjected to myocardial ischemia
and reperfusion. Cardiovascular
Research, 2004, 62:135-144
3.
HR. Liu, F. Gao, L. Tao, WL. Yan,
E. Gao, TA. Christopher, BL. Lopez, A.Hu, XL. Ma. Antiapoptotic
mechanisms of benidipine in the ischemic/reperfused heart. Br J
Pharmacol, June 1, 2004,142 (4):627-34
4.
L.Tao, HR.Liu,
F.Gao, Y.Qu,
TA.Christopher, BL.Lopez,
and XL. Ma. Mechanical traumatic injury without
circulatory shock causes cardiomyocyte apoptosis: role of
reactive nitrogen and
reactive oxygen species. Am
J Physiol Heart Circ Physiol ,Feb 4,2005,288:H2811-H2818
5.
HR. Liu, RR. Zhao, XY. Jiao, YY. Wang, M.Fu. Relationship of Myocardial
Remodeling to Genesis of Serum Autoantibodies to cardiac Beta1-Adrenoceptors
and Muscarinic Type 2 Acetylcholine Receptors in Rats. Journal of the
American
College
of Cardiology 2002, 39(11): 1866-1873
6.
HR Liu, RR Zhao, JM Zhi, BW Wu, Michael Fu. Screening of Serum
Autoantibodies to Cardiac ¦Â1-adrenoceptors and M2-muscarinic
Acetylcholine Receptors in 408 Healthy Subjects of Varying Ages.
Autoimmunity 1999,29:43-51
7.
Huirong Liu, Jianming Zhi, Xiaoliang Wang, Sa Li, Weifang Zhang, Xinliang Ma,
Rongrui Zhao. Effects of immunization with synthetic peptides
corresponding to the sequence of the second extracellular loop
of either ¦Â1-adrenoceptor or M2-muscarinic
receptor on cardiac activity in rats. EXPERIMENTAL
BIOLOGY 2006
8.
Hui-Rong Liu, Xiao-Liang Wang, Mei-Xia Li, Jin Wang, Lin Zuo, Zhong-Mei He, Xin
L. Ma, Rong-Rui Zhao. Negative
inotropic effects
of autoantibodies
against ¦Â3-adrenoceptor
in patients
with dilated
cardiomyopathy on isolated cardiomyocyte.
EXPERIMENTAL BIOLOGY
2006
9.
HR. Liu, L. Tao, E. Gao, BL. Lopez,
TA. Christopher, TL. Yue, XL. Ma. Anti-Apoptosis
Effects and its Mechanisms of a Peroxisome Proliferator-activated
Receptor-gamma Agonist in Hypercholesterolemic Rabbits Subjected
to Myocardial Ischemia and Reperfusion .
Circulation,
October 28,2003, Supplement 10
10.
L.Tao,
HR.Liu, E.Gao, ZP.Teng, BL.Lopez, TA.Christopher, XL.Ma.
Antioxidative, Antinitrative, and Vascularprotective Effects of
a Peroxisome Proliferator-activated Receptor-gamma Agonist in
Hypercholesterolemia. Circulation, December 2, 2003,108:2805-2811
11.
H.R.Liu,
R.R.Zhao, J.M.Zhi, B.W.Wu and Fu LX. Screening of serum
autoantibodies against cardiac b1-adrenoceptors
and M2-muscarinic acetycholine receptor in 408 healthy subjects
with varying ages. Autoimmunity.
1999; 29:43-51.
12.
LIU Huirong
,Wang Fengzhi, Zhang weifang,and zhao rongrui. Detection of
antibodies against cardiac b1-adrenoceptor.
Chinese Journal of Medical Laboratory Sciences, 1999 ;22(6):339-341.
13.
LIU Huirong,
Li Sa , Jiao Xiangying and ZHAO Rongrui. Investigation of
Streptavidin-ELISA for IgG antibody against cardiac
M2-muscarinic receptor in sera. Chinese
Journal of Experimental & Clinical Immunology. 1999;11(3):174-177.
14.
LIU Huirong
and ZHAO Rongrui. Relation of autoantibodies against cardiac b1-
and M2-receptors to cardiac structure and functional
activity. Caps News
Communication
(Physiology).1999;18(5):119-120.
15.
LI
Sa, LIU Huirong, JIAO Xiangying and ZHAO Rongrui.
Relation of cardiac structural and functional changes to the
genesis of cardiac receptor autoantibodies.
Chinese Journal of Pathophysiology. 1999;15(12):1060-1063.
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