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(1)
Education:
09. 1992-04. 1995:
Postgraduate student for doctor degree in II. Institute of
Physiology of University Heidelberg (Germany).
09. 1985-07.1988:
Postgraduate student for Master Degree in Department of Physiology
of the Bethune University of Medical Sciences in Changchun
(China).
03. 1978-12. 1982:
Undergraduate student in Faculty of Medicine of Yanbian Medical
College (China).
(2).Work experiences:
06. 1999-now:
Professor and
director of department of physiology in Zhongshan Medical School
of Sun Yat-sen University
06.1997-05.1999:
Postdoctor fellow in Institute of Physiology of Christian-Albrechts-University
in Kiel (Germany).
05.1995-05.1997:
postdoctor
fellow in II. Institute of Physiology of University Heidelberg
(Germany).
09. 1988-07. 1992:
Lecturer in the Department of Physiology of North China Coal
Medical College in Tanshan (China).
01. 1983-07. 1985:
Assistant in the Department of Physiology of Inner Mongolia
Medical College (China).
(3) Academic memberships
The president of the
Society for Physiology of Guangdong province.
The number of Society
for Physiology of China.
The number of Society
for Neuroscience (USA).
1.
Main scientific achievements
(1)
Reporting at first time the long-term potentiation (LTP) of
C-fiber evoked field potentials in spinal dorsal horn and
discovering that activation of spinal NMDA, NK1 and NK2 receptors
is essential for the induction of the spinal LTP. Natural noxious
stimuli can also produce the spinal LTP but inhibited by
descending inhibitory system. The spinal LTP is believed to
underly hyperalgesia.
(2)
Reporting at first time that stimulation of A¦Ä fibers produces
long-term depression (LTD) of C fiber evoked field potentials in
spinal dorsal horn in normal animals but produces LTP in
spinallized ones. Confirming the descending inhibitory pathways
determing the direction of plasticity in synaptic transmission in
spinal dorsal horn.
(3)
Discovering that axotomized muscle afferents but no skin afferents
develop ongoing discharges of dorsal root ganglion and under the
condition of nerve injury uninjuured muscle afferents also produce
spontanious discharges.
Important Publications
1.
Liu, X.-G.
and Sandkuhler, J. (1995) Long-term potentiation of C-fiber-evoked
potentials in the rat spinal dorsal horn is prevented by spinal
NMDA receptor blockage, Neurosci. Lett., 191: 43-46.
2.
Liu, X.-G.
and Sandkuhler, J.(1995) The effects of extrasynaptic substance P
on nociceptive neurons in laminae I and II in rat lumbar spinal
dorsal horn. Neuroscience, 68:1207-1218.
3.
Liu, X.-G.
and Sankuhler, J. (1997) Characterization of long-term
potentiation of C-fiber-evoked field potentials in spinal dorsal
horn of adult rat: essential role of NK1 and NK2 receptors. J.
Neurophysiol., 78: 1973-1997.
4.
Sandkuhler, J, Liu, X.-G.
(1998) Induction of long-term potentiation at spinal synapses by
noxious stimulation or nerve injury. Eur. J. Neurosci., 10:
2476-2480.
5.
Liu, X.-G.
and Sandkuhler, J. (1998) Activation of spinal N-methyl-D-aspartate-
or neurokinin-receptors induces long-term potentiation of
C-fiber-evoked field potentials in spinalized rats.
Neuroscience, 86: 1209-1216.
6.
Liu, X.-G.,
Morton, C.R., Azkue, J.J., Zimmermann, M. and Sandkuhler, J.
(1998) Long-term depression of C-fiber evoked spinal field
potentials by stimulation of primary afferent A-delta-fibers in
the adult rat. Eur. J. Neurosci., 10: 3069-3075.
7.
Liu, X.-G.,
Eschenfelder, S., Habler H.-J. and Janig, W. (2000) Spontaneous
activity of axotomized neurons after L5 spinal nerve injury in
rats. Pain, 84:309-318.
8.
Martin Michaelis, Xianguo Liu
and Wilfrid Jänig
£¨2000£©Axotomized
and intact muscle afferents but no skin afferents develop ongoing
discharges of dorsal root ganglion origin after peripheral nerve
lesion. J. Neurosci, 20:2742-2748. |
