Xianguo Liu

Curriculum Vitae

Name: Xianguo Liu

Date of birth: 27.02.1957   

Place of birth: Naiman, China   

Foreign languages: English and German

 (1) Education:

09. 1992-04. 1995: Postgraduate student for doctor degree in II. Institute of Physiology of University Heidelberg (Germany).

09. 1985-07.1988: Postgraduate student for Master Degree in Department of Physiology of the Bethune University of Medical Sciences in Changchun (China).

03. 1978-12. 1982: Undergraduate student in Faculty of Medicine of Yanbian Medical College (China).

(2).Work experiences:

06. 1999-now: Professor and director of department of physiology in Zhongshan Medical School of Sun Yat-sen University

 

06.1997-05.1999: Postdoctor fellow in Institute of Physiology of Christian-Albrechts-University in Kiel (Germany).

05.1995-05.1997: postdoctor fellow in II. Institute of Physiology of University Heidelberg (Germany).

09. 1988-07. 1992: Lecturer in the Department of Physiology of North China Coal Medical College in Tanshan (China).

01. 1983-07. 1985: Assistant in the Department of Physiology of Inner Mongolia Medical College (China).

(3) Academic memberships

The president of the Society for Physiology of Guangdong province.

The number of Society for Physiology of China.

The number of Society for Neuroscience (USA).

 

1.      Main scientific achievements

(1)     Reporting at first time the long-term potentiation (LTP) of C-fiber evoked field potentials in spinal dorsal horn and discovering that activation of spinal NMDA, NK1 and NK2 receptors is essential for the induction of the spinal LTP. Natural noxious stimuli can also produce the spinal LTP but inhibited by descending inhibitory system. The spinal LTP is believed to underly hyperalgesia.

(2)     Reporting at first time that stimulation of A fibers produces long-term depression (LTD) of C fiber evoked field potentials in spinal dorsal horn in normal animals but produces LTP in spinallized ones. Confirming the descending inhibitory pathways determing the direction of plasticity in synaptic transmission in spinal dorsal horn.

(3)     Discovering that axotomized muscle afferents but no skin afferents develop ongoing discharges of dorsal root ganglion and under the condition of nerve injury uninjuured muscle afferents also produce spontanious discharges.

 

Important Publications

1.       Liu, X.-G. and Sandkuhler, J. (1995) Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal NMDA receptor blockage, Neurosci. Lett., 191: 43-46.

2.       Liu, X.-G. and Sandkuhler, J.(1995) The effects of extrasynaptic substance P on nociceptive neurons in laminae I and II in rat lumbar spinal dorsal horn. Neuroscience, 68:1207-1218.

3.       Liu, X.-G. and Sankuhler, J. (1997) Characterization of long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn of adult rat: essential role of NK1 and NK2 receptors. J. Neurophysiol., 78: 1973-1997.

4.       Sandkuhler, J, Liu, X.-G. (1998) Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury. Eur. J. Neurosci., 10: 2476-2480.

5.       Liu, X.-G. and Sandkuhler, J. (1998) Activation of spinal  N-methyl-D-aspartate- or neurokinin-receptors induces long-term potentiation of C-fiber-evoked field potentials in spinalized rats. Neuroscience, 86: 1209-1216.

6.       Liu, X.-G., Morton, C.R., Azkue, J.J., Zimmermann, M. and Sandkuhler, J. (1998) Long-term depression of C-fiber evoked spinal field potentials by stimulation of primary afferent A-delta-fibers in the adult rat. Eur. J. Neurosci., 10: 3069-3075.

7.       Liu, X.-G., Eschenfelder, S., Habler H.-J. and Janig, W. (2000) Spontaneous activity of axotomized neurons after L5 spinal nerve injury in rats. Pain, 84:309-318.

8.       Martin Michaelis, Xianguo Liu and Wilfrid Jänig 2000Axotomized and intact  muscle afferents but no skin afferents develop ongoing discharges of dorsal root ganglion origin after peripheral nerve lesion. J. Neurosci, 20:2742-2748.