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梅岩艾,
1954年4月6日出生
教授、博导、复旦大学生命科学学院科研副院长、生理学和生物物理学系代系主任
学习和工作经历
1980年上海第二医科大学医学系毕业，同年留校任基础部生理教研室助教。
1983至1986年上海第二医科大学生理专业硕士研究生，毕业后继续留校任讲师。
1990至1991年在巴黎第十二大学生理系进修，学习膜片箝技术。
1991至1995年在法国鲁昂大学生命学院生物系、国家医学研究院所属细胞和分子神经内分泌实验室攻读神经生物学
博士研究生学位
1995年6月获博士学位后回国,同年11月晋升为副教授。
1996年10月调入复旦大学生理学和生物物理学系，1999年5月晋升为教授。
2001年评为博士生导师。
学术兼职
中国生物物理学会常务理事；
上海生物物理学会常务理事
上海神经科学会理事
中国生理学报编委；
中国生物物理学报编委
目前主要从事的研究内容为:
1.
神经递质和神经肽受体激活后对细胞膜离子通道的调控及其跨膜信号转导机制.
2.
细胞膜离子通道在神经和心血管细胞发育、增殖、凋亡和迁移中的作用及机制。
3.
细胞膜离子通道的结构与功能。
近年来发表的SCI论文：
1. Xin Wang, Jie Bao, Xi-Min Zeng, Zheng Liu,
and Yan-Ai Mei Elevation of intracellular Ca2+ modulates
A-currents in rat cerebellar granule neurons. Journal of
Neuroscience Research 2005 (4): 530-540 AUG 15.
2. Bo-Xun Lu, Lin-Yun Liu, Zhao-Ming Li, Zhi-Hong
Zhang, Yan-Ai Mei. Inhibition of Na+ channel currents in rat
myoblasts by 4-aminopyridine. Toxicology and Applied
Pharmacology. 2005；15; 207(3):275-82
3. Lin-Yun Liu, Xiao-Wei Fei, Zhao-Min Li, Yan-Ai
Mei. The nonsteroidal anti-inflammatory drug, diclofenac,
activates the transient outward K+ current in rat cereballer
granule cells. Neuropharmacology 2005 ,48: 918-926.
4. Hu Chang-Long, Gao Zhen-Yu, Liu Zheng,
Zhang Zhi-Hong, Mei Yan-Ai
2-iodomelatonin prevents apoptosis of cerebellar granule neurons
via inhibition of A-type transient outward K+ currents. J.
Pineal Res. 2005, 38:53-61
5. Liao L, Zeng XM, Gao PJ, Zhu DL, Mei YA .PKC
pathway associated with the expression of an A-type K+ channel
induced by TGF-beta1 in rat vascular myofibroblasts. Biochem
Biophys Res Commun. 2005 Oct 28;336(3):854-9.
5. Yan-ai Mei, D. Vaudry et al, PACAP inhibits
delayed rectifier potassium current via a cAMP/PKA transduction
pathway. Evidence for the involvement of Ik in the
anti-apoptosis action of PACAP. Eur. J. Neuronsci. 2004
14:225-230.
6．MiOu Zhou, Zheng Liu, ChangLong Hu,
ZhiHong Zhang and Yan-Ai Mei
Developmental Regulation of a Na+-activated Fast Outward K+
Current in Rat Myoblasts. Cell Physiol Biochem 2004;14 ：225-230.
7．Lin-Yun Liu , Chang-Long Hu, Lai-ji Ma,
Zhi-hong Zhang, and Yan-Ai Mei. ET-1 inhibits B-16 murine
melanoma cell migration by decreasing K+ currents. Cell Motility
Cytoskel . 2004: 58:127-136.
8．Song Jiao, Ming-Ming Wu, Chang-Long Hu,
Zhi-Hong Zhang and Yan-Ai Mei.
Melatonin receptor agonist 2-iodomelatonin prevents apoptosis of
cerebellar granule neurons via K+ currents inhibition. J. Pineal
Res. 2004; 36:109-116
.
9. Lai-Ji Ma , Lin-Yun Liu, Song Jiao, Shao-Ming Wei, Yan-Ai Mei
Ca2+- inactivated K+ current modulated by endothelin-I in B-16
murine melanoma cells. Pigment Cell Res. 2003,16:463-469
10．ZHOU Mi-ou, JIAO Song, LIU Zheng, ZHANG
Zhi-hong, Mei Yan-ai. Luzindole, a melatonin receptor
antagonist, inhibits the transient outward K+ current in rat
cerebellar granule cells. Brain Res.2003,970: 169-177
11. Wu M, Gao P, Jiao S, Zhu D, Zhang Z, Mei
Y.A. TGF- 1 induceds the expression of inactivating K+(IA)
channels in rat vascular myofiblast. BBRC 2003 30:17-23. 2.836
12．Hua Wei, Yan Ai Mei, Jia Ting Sun, Han Ging Zhou, Zhi Fong
Zhang. Regulation of sewlling-activated chloride channels in
embryonic chick heart cells. Cell Res. 2003, 1: 21-28.
13. Wei DS, Mei YA, Bagal A, Kao JP, Thompson
SM, Tang CM.
Compartmentalized and binary behavior of terminal dendrites in
hippocampal
pyramidal neurons. Science. 2001 Sep 21;293(5538):2272-5.
14. Mei YA, Lee PP, Wei H, Zhang ZH, Pang SF.
Melatonin and its analogs potentiate the nifedipine-sensitive
high-voltage-activated calcium current in the chick embryonic
heart cells.
J Pineal Res. 2001 Jan;30(1):13-21.
15. Huan CL, Zhou MO, Wu MM, Zhang ZH, Mei YA.
Melatonin receptor Activate the rectify inward K+ current by a
MT2 melatonin receptor in cerebellar granule cells. Brain Res,
2001,917:182-190.
16. Wei H, Mei YA, Wu MM, Sun JT, Zhou HQ,
Zhang ZH.
Swelling-activated chloride currents in embryonic chick heart
cells.
Acta Pharmacol Sinica. 2000 Nov;21(11):986-90.
17. Mei YA, Wu MM, Huan CL, Sun JT, Zhou HQ,
Zhang ZH.
4-aminopyridine, a specific blocker of K(+) channels, inhibited
inward Na(+)
current in rat cerebellar granule cells.
Brain Res. 2000 Aug 4;873 (1):46-53.
18. Mei YA, Huang LX, Wei H, Sun JT, Zhou HQ,
Zhang ZH.
Characterization of outward potassium current in embryonic chick
heart cells.
Acta Pharmacol Sinica. 1999 Apr;20(4):303-7.
19. Mei YA.
High-voltage-activated calcium current and its modulation by
dopamine D4 and
pituitary adenylate cyclase activating polypeptide receptors in
cerebellar
granule cells. Acta Pharmacol Sinica. 1999 Jan;20(1):3-9.
20. Mei YA, Vaudry H, Cazin L.
Patch clamp study on mechanism of adenosine-induced inhibitory
effects in frog
pituitary melanotrophs. Acta Pharmacol Sinica. 1996
Sep;17(5):385-9.
21. Soriani O, Vaudry H, Mei YA, Roman F,
Cazin L. Sigma ligands stimulate the electrical activity of frog
pituitary melanotrope cells through a G-protein-dependent
inhibition of potassium conductances. J Pharmacol Exp Ther. 1998
286(1):163-71.
22. Mei YA, Soriani O, Castel H, Vaudry H,
Cazin L. Adenosine potentiates the delayed-rectifier potassium
conductance but has no effect on the hyperpolarization
-activated Ih current in frog melanotrophs. Brain Res. 1998
793(1-2):271-8.
23. Mei YA, Vaudry H, Cazin L. Patch clamp
study on mechanism of adenosine-
induced inhibitory effects in frog pituitary melanotrophs. Acta
Pharmacol Sinica. 1996 Sep;17(5):385-9.
24. Gonzalez BJ, Basille M, Mei YA, Vaudry D,
Fournier A, Cazin L, Vaudry H.
Ontogeny of PACAP and PACAP receptors in the rat brain: role of
PACAP in the
cerebellum during development. Ann N Y Acad Sci. 1996
26;805:302-13;
25. Mei YA, Le Foll F, Vaudry H, Cazin L.
Adenosine inhibits L- and N-type calcium channels in pituitary
melanotrophs.
Evidence for the involvement of a G protein in calcium channel
gating.
J Neuroendocrinol. 1996 Feb;8(2):85-91.
26. Mei YA, Louiset E, Vaudry H, Cazin L.
A-type potassium current modulated by A1 adenosine receptor in
frog
melanotrophs.J Physiol. 1995 Dec 1;489 ( Pt 2):431-42.
27. Mei YA, Griffon N, Buquet C, Martres MP,
Vaudry H, Schwartz JC, Sokoloff P,Cazin L. Activation of
dopamine D4 receptor inhibits an L-type calcium current in
cerebellar granule cells. Neuroscience. 1995 Sep;68(1):107-16.
28. Mei YA, Vaudry H, Cazin L. Inhibitory
effect of adenosine on electrical activity of frog melanotrophs
mediated through A1 purinergic receptors.
J Physiol. 1994 481 ( Pt 2):349-55.
29. Louiset E, Mei YA, Valentijn JA, Vaudry H,
Cazin L.
Characterization of the GABA-induced current in frog pituitary
melanotrophs.
J Neuroendocrinol. 1994 Feb;6(1):39-46.
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