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 Yong-Fu
Xiao, MD, PhD,
was graduated from
Suzhou
Medical
College
(Medicine) in 1977, from
Shanghai
Medical
University
(Physiology, Master) in 1983, and from
University
of
Medicine
and Dentistry of New Jersey (Pharmacology, PhD) in 1992. After PhD
graduation, he was trained as a postdoctoral fellow at the
Department of Physiology, University of Pennsylvania School of
Medicine and at the Department of Pharmacology,
Georgetown
University
Medical
Center
during 1992 to 1994. He was a research fellow at the Department of
Medicine,
Massachusetts General
Hospital
,
Harvard
Medical
School
in 1994. He was appointed as an Assistant Biophysicist at the
Department of Medicine,
Massachusetts General
Hospital
(1995-1997) and instructor in Medicine at the Cardiovascular
Division, Department of Medicine,
Beth
Israel
Deaconess
Medical
Center
(1995-1998),
Harvard
Medical
School
. He was a Staff Scientist at the Cardiovascular Division,
Department of Medicine,
Beth
Israel
Deaconess
Medical
Center
(1999-2004), and Assistant professor of Medicine,
Harvard
Medical
School
(1999-2004). Currently, he is an Associate Biophysicist at the
Department of Medicine,
Massachusetts General
Hospital
,
Harvard
Medical
School
(1998-2006) and a Principal Scientist at Medtronic, Inc.
(2004-2006).
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His research interests include the structure and function of
cardiac ion channels, the cellular and molecular mechanism of the
antiarrhythmic effect of the n-3 polyunsaturated fatty acids,
cardiac repair by transplantation of stem cells, and cytochrome
P450 regulation of cardiac function and ion channels.
Contact
information: Cardiac Rhythm Disease Management, Medtronic Inc.,
7000 Central Avenue NE
, B252,
Minneapolis
,
MN
55432-3576
,
USA
. Phone: 763-514-4256; Fax: 763-514-3911; Email: yong-fu.xiao@medtronic.com.
Selected
recent publications:
1.
Leaf
A, Kang JX, Xiao Y-F, Billman
GE. Clinical Prevention of Sudden Cardiac Death by n-3
Polyunsaturated Fatty Acids and Mechanism of Prevention of
Arrhythmias by n-3 Fish Oils. Circulation. 2003; 107(21):2646-52.
2.
Chen
Y, Ke Q, Yang Y, Rana JS, Morgan JP, Xiao
Y-F. Cardiomyocytes
overexpressing TNF-a attract migration of embryonic stem cells via
activation of p38 and c-Jun N-terminal kinase. FASEB J. 2003; 17
(15):2231-2239.
3.
Xiao
Y-F, Ke Q, Seubert JM, Bradbury JA,
Graves J, Miller L, Falck JR, Krausz K, Gelboin HV, Morgan JP,
Zeldin DC. Enhancement of L-type calcium currents in transgenic
mice with cardiac-specific overexpression of CYP2J2. Mol Pharmacol.
2004; 66(6):1607-16.
4.
Xiao
Y-F, Ma L, Wang SY, Wang GK, Morgan JP, Leaf A. Potent Block of Inactivation-deficient Na+
Channels by n-3 Polyunsaturated Fatty Acids. Am J Physiol
Cell Physiol. 2006; 290(2):C362-70.
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