许文燮

许文燮,1983年毕业于吉林省延边医学院医学系,获学士学位,1993年毕业于延边医学院生理学专业,获硕士学位,1997年毕业于韩国国立汉城大学医学院,获博士学位。20003月~20013月在韩国国立全北大学医学院生理学教研室从事博士后工作。现任上海交通大学生命科学院生物医学工程系教授、博士生导师。现兼任中国神经科学会理事、上海神经科学会理事、中国生理学会消化内分泌代谢生殖生理学专业委员会委员、中国生理学会青年工作委员会委员、上海神经科学会理事、国家自然科学基金项目评人,中国《生理学报》和《世界华人消化病学》杂志的编委,《中国药理学报》、《中国神经科学》等杂志的同行审稿人。目前主要从事消化道平滑肌动力学及其离子通道机制方面的研究工作。2000年以来,共承担国家自然科学基金资助课题四项、教育部资助课题两项,在国内外重要的学术刊物和各类学术会议上发表了80多篇学术论文,其中收录于《SCI》论文25篇,已鉴定科研成果两项。2002年被评为吉林省主讲教授、教育部优秀骨干教师,2004年获得吉林 省科技进步二等奖。近五年来,参编《糖尿病的基础与临床》(人民军医出版社)和《神经胃肠病学与动力》(科学出版社)等两部专著,主编或参编全国成人教育专科用《生理学》(人民军医出版社)、卫生部计划教材专科用《生理学》(人民卫生出版社)、科学出版社出版的21世纪医学本科教材《生理学》等三部教材。1997年以来,共招收30名研究生,其中硕士生19名已毕业16名,招收博士生12名已毕业9名。

近期发表的论文:

1.   An SC, Xu WX, Kim SJ, So I, Kang TM, Kim KW. Effect of purinergic agonist on mechnical and electrical activities of gastric smooth muscle of guinea-pig. J. Smooth Muscle Res. 31: 60-63, 1995.

2.    Xu WX, Kim SJ, So I, Kang TM, Kim KW: Effect of stretch on calcium channel currents recorded from the antral circular myocytes of guinea-pig stomach. Pflugers Arch. 432: 159-164, 1996.

3.    Xu WX, Kim SJ, So I, Kang TM, Kim KW: Role of actin microfilament in osmotic stretch-induced increase of voltage-operated calcium channel current in guinea-pig gastric myocytes. Pflugers Arch. 434: 502-504, 1997. 

4.    Xu WX, Kim SJ, So I, Kang TM, Kim KW. Volume-sensitive chloride current activated by hyposmotic swelling in antral gastric myocytes of the guinea-pig.  Pflugers Arch. 435: 9-19, 1997. 

5.    Xu WX, Kim SJ, So I, Kang TM, Kim KW. Effects of arachidonic acid on the calcium channel current (IBa)and on the osmotic stretch-induced increase of IBa in guinea-pig gastric myocytes. Korean J. Physiol. Pharmacol. 1: 435-443, 1997.

6.   Kang TM, Xu WX, Kim SJ, So I, Kim KW. Evidence for Adenosine Triphosphate (ATP) as an Excitatory Neurotransmitter in Guinea-pig Gastric Antrum. The Korean J Physiol & Pharmacol, 1999, 3: 165-174.

7.   Xu Wen Xie, Li Ying, Li Zhai Liu. Effects of different kinds of stretch on voltage-dependent calcium current in antral circular smooth muscle cells of the guinea-pig. Acta Physiologica Sinica, 2000, 52: 69-74.

8.   Li Ying, Xu Wen Xie, Li Zai Liu. Effects of nitroprusside, 3-morpholino-sydnonimine, and spermine on calcium-sensitive potassium currents in gastric antral circular myocytes of guinea pig.  Acta Pharmacol Sin, 2000, 21: 571-576. 

9.  Jin Nan-Ge, Li Ying, Xu Wen Xie and Li Zai-Liu: Exogenous nitric oxide directly inhibits antral circular muscle motility of rat sromach in vitro. World chinese journal of digestion,6(3): 188-191.1998

10.   Jin Jing Yu , Xu Wen Xie et al. Effect of nitric oxide on electric and mechanical activities of gastric antral circular muscles in guinea pigs. Acta Pharmacol Sin, 2000, 21: 369-373.

11.   Piao Lin, Li Ying, Li Lin, Xu Wen Xie. Increment of calcium-activated and delayed rectifier potassium current by hyposmotic swelling in gastric antral circular myocytes of guinea pig. Acta Pharmacol Sin, 2001, 22: 566-572。

12.    Lin Piao, Ying Li, Lin Li, Nan Ge Jin, Zai Liu Li, Wen Xie Xu. The involvement of calcium mobilization in the calcium-activated potassium currents actvated by hyposmotic swelling in gastric antral circular myocytes of the guinea-pig. Jpn J Physiol, 2001, 51: 223-230。

13.  XUN CUI, JIN FU WEN, YINGYU JIN, WEN XIE XU, SUNG ZOO KIM, SUHN HEE KIM, HO SUB LEE, AND KYUNG WOO CHO. Protein kinase-dependent and Ca2+-independent cAMP inhibition of ANP release in beating rabbit atria. Am J Phiol Reguatory Integrative comp Phyiol 2002, 282:R1477-1489.

14.   Lin Li, Nan-Ge Jin, Lin Piao, Ming-Yu Hong, Zheng-Yuan Jin, Ying Li, Wen-Xie Xu. Hyposmotic membrane stretch potentiated muscarinic receptor agonist-induced depolarization of membrane potential in guinea-pig gastri myoccytes. World J Gastroenterol 2002, 8 (4): 724-727.  

15.  Yong Chun Yu, Hui Shu Guo, Piao Lin, Li Lin, Lee Zai Liu, Xu Wen-Xie. Intracellular calcium involved in muscarinic currents increased by hyposmotic membrane stretch in gastric myocytes of guinea-pig. Acta Pharmacol Sin 2002, 23: 961-1056.

16.    Yong Chun Yu, Ying Li, Lin Piao, Lin Li, Zhai Liu Li, Wen Xie Xu. The role of calcium mobilization in sodium nitroprusside-induced increase of calcium-activated potassium currents in gastric antral circular myocytes of guinea-pig. Acta Pharmacol Sin 2003, 24: 819-825.

17.    Zuo Yu Wang, Yong Chun Yu, Yi Feng Cui, Lin Li , Hui Shu Guo, Zai Liu Lee, Wen Xie Xu.  Role of actin microfilament in hyposmotic membrane stretch-induced increase of muscarinic current in guinea-pig gastric myocytes. Acta Physiologica Sinica  2003, 55: 177-182.

18.  CUI Yi-Feng 1, JIN Hai2, GUO Hui-Shu1, LI Lin1, YU Yong-Chun1, XU Wen-Xie. Effect of unsaturated fatty acid on muscarinic current in guinea pig gastric myocytes. Acta Pharmacol Sin  2003, 24: 283-288.

19.   Cui Yi-Feng 1, Li Lin 1, Yu Yong-Chun 1, Jin Zheng-Yuan 1, Lee Zai-Liu 1, Xu Wen-Xie. Role of unsaturated fatty acids in the process of hyposmotic membrane stretch enhanced-muscarinic current in guinea pig smooth muscle cells. Acta Physiologica Sinica,2003,55:96-100.

20.  Hui-Shu Guo1, Zheng-Jin1, Zheng-Yuan Jin1, Zhe-Hao Li2, Yi-Feng Cui1, Zuo-Yu Wang, Wen-Xie Xu. Comparative study in the effect of C-type natriuretic peptide on gastric motility in various animals. World J Gastroenterol  2003; 9(3): 547-552.

21.    GUO Hui-Shu, CUI Xun, CUI Yong-Gen3 , Kim Sung-Zoo4, CHO Kyung-Woo4, LI Zai-Liu, Xu Wen-Xie. Inhibitory effect of C-type natriuretic peptide on spontaneous contraction in gastric antral circular smooth muscle of rat1. Acta Pharmacol Sin   2003, 24: 1021-1026

22.   Hui-Shu Guo, Zheng-Xu Cai, Hai-Feng Zheng, Xiang-Lan Li, Yi-Feng Cui, Zuo-Yu Wang, Wen-Xie Xu. The role of calcium-activated potassium currents in CNP-induced relaxation of gastric antral circular smooth  muscle in guinea-pigs  World J Gastroenterol, 2003, 9(9): 2054-2059.

23.    Li Xiang Lan, Zheng Hai FengJin Zheng YuanYang MengLi Zhai LiuXu Wen Xie. Effect of actin microfilament on potassium current in guinea pig gastric myocytes. World J Gastroenterol   2004, 10: 3303-3307  

24.   Jin Zheng1, Guo Hui-Shu2, Hong Ming Yu2, Li Xiang Lan2, Xu Wen-Xie1. Effects of purinergic analogues on spontaneous contraction and electrical activities of gastric antral circular muscle in guinea-pig.  Acta Physiologica Sinica, 2004, 56: 678-684.

25.     Piao WH, Song XG, Liu MC, He Y, Zhang HH, Xu WX, Li ZL, Zhang HQ, Ling SG, Wang GQ. Cloning, expression, and purification of HLA-A2-BSP and beta -2m in Escherichia coli. Protein Expr Purif. 2004 Jun;35(2):210-7. 

26.     Piao WH, He Y, Xi HL, Sun XT, Zhang HH, Xu JH, Zhao H, Xu WX, Li ZL, Wang GQ. Construction of HLA-A2-peptide tetramer and application in HBV/HCV infection. Zhonghua Yi Xue Za Zhi. 2004,8:1818-22. 

27.    ZHENG Hai-Feng, LI Xiang-Lan, JIN Zheng-Yuan, SUN Jia-Bin, LI Zai-Liu, XU Wen-Xie. Effect of unsaturated fatty acid on calcium-activated potassium current in guinea pig gastric myocytes. World J Gastroenterol  2005, 11: 672-675.

28.   Meng Yang, Xing Lan Li , Hui Ying XU , Jia Bin Sun, Bin Mei , Hai Feng Zheng, Lian Hua Piao, Zhai Liu Li, Wen Xie Xu.   Role of Arachidonic acid in hyposmotic membrane stretch-induced increase in calcium-activated potassium current in gastric myocytes. Acta Pharmacol Sin, 2005, 261233-1242.  

29. Li CH, Piao DM, Xu WX, Yin ZR, Jin JS, Shen ZS. Morphological and serum hyaluronic acid, laminin and type IV collagen changes in dimethylnitrosamine-induced hepatic fibrosis of rats. World J Gastroenterol. 2005, 11: 7620-4.  

30.   Kim YC, Sim JH, Lee SJ, Kang TM, Kim SJ, Kim SR, Youn SJ, Lee SJ, Xu WX, Kim KW. Regulation of L-type calcium channel currents by somatostatin in guinea-pig gatric myocytes. KJPP, 2005, 9: 103-108.  

31.   Chun-hui Li, Zong-wei Yang, Zheng-ri Yin, Zheng Jin, De-gang Xing, Lian Hua Piao, Yong-chul Kim, Wen-xie Xu. Relationship between atrial natriuretic peptide-immunoreactive cells and microvessels in rat gastric mucosa. Acta Pharmacol Sin2006, 27: 205-11.