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Education and work experience:
Jul.1978-July.1983
Yanbian Medical college
Bachelor
Aug.1983-Nov.1988
Department of Physiology,
Yanbian Medical college Assistant
Dec.1988-Nov.1993
Department of Physiology,
Yanbian Medical college
Lecturer
Mar.1990-Mar.1991
Department of Physiology,
Beijing Medical University
Visit researcher
Jan. 1994-Dec.1996
Department of Physiology,
Yanbian Medical college Associate
professor
Sep.1994-Sep.1997
Department of Physiology,
Medical
School
,
Seoul National
University
,
Korea
Ph.D
Jan.1997-Sep.2003 Department
of Physiology,
Medical
College
,
Yanbian
University
Professor
Mar.2000
–Mar.2001 Department of Physiology,
Medical
School
,
Jeonbug National University
,
Korea
Post Dr
Oct.2003-now
Department of Biomedical
Engineering, College of Life Science & Biotechnology, Shanghai
Jiaotong Univerty Professor
Membership
and Committees:
Member of the American Physiological Society.
Member of the
Chinese Physiological Society.
Member of the
Chinese Neuroscience Society.
Digestion,
Endocrine, Metabolism and Reproduction Professional Committee,
Chinese Physiological Society.
Council member
Editorial
Boards:
Acta Physiol Sin
2002-present.
J Med Sci Yanbian University
2000-present
World Chinese J Digestiol
2003- present
Editorial reviews for Scientific Journals:
Acta Pharmacol Sin
Chinese Neuroscience
Prizes:
A Prize of Outstanding Key Teacher in Chinese Ministry of
Education 2002
Second
Prize of
Science and Technology Advance in Jilin Province 2004
Grants:
1.
In charge of the project:
The study of membrane stretch on muscarinic current and its
mechanism in gastric myocytes, supported
by the grant from National Nature Science Foundation of China, 1999.
2.
In charge of the project:
The study of membrane stretch on delayed rectifying potassium
currents and its mechanism in gastric myocytes, supported by the grant from Ministry of Education of
China, 2000.
3.
In charge of the project:
The study of membrane stretch on calcium-activated potassium
currents and its mechanism in gastric myocytes, supported by the grant from Ministry of Education of
China
, 2002.
4.
In charge of the project:
The study of natriuretic peptides on ion channel currents and its
mechanism in gastric myocytes, supported
by the grant from National Nature Science Foundation of China, 2001.
5.
In charge of the project:
The study of natriuretic peptides on pacemaker currents and its
mechanism in gastric interstitial cell of Cajal, supported by the grant from National Nature Science Foundation of China, 2004.
Published
Abstracts:
1.
Wen Xie Xu, et al.
Hyposmotic cell stretch increases voltage-dependent calcium
current in guinea-pig gastric antral circular smooth muscle cells.
Gastroenterology, 1996, 110: A783.
2.
Wen Xie Xu, et al. ATP as an
excitatory NANC neurotransmitter in guinea-pig
gastric antral circular muscle. Gastroenterology, 1996, 110: A784.
3.
Wen Xie Xu, et al. Modulation of
L-type calcium channel current by fatty acid in antral gastric
myocytes of guinea-pig. 48th Annual Meeting of the
Korean Physiological Society, October 17-18, 1996,
Seoul
Korea
.
4.
Wen Xie Xu et al. Hyposmotic
stimulation activates outward rectifying chloride current in
antral gastric myocytes of guinea-pig. 48th Annual
Meeting of the Korean Physiological Society, October 17-18, 1996,
Seoul
Korea
.
5.
Wen Xie Xu, et al. Effect of
stretch on calcium channel currents recorded from the antral
circular myocytes of guinea-pig. Federation Meeting of Korean
Basic Medical Scientists, April 24-25, 1996,
Seoul
Korea
.
6.
Wen Xie Xu, et al.
Volume/stretch-sensitive chloride current in guinea-pig antral
gastric myocytes. Federation
Meeting of Korean Basic Medical Scientists, April 24-25, 1996,
Seoul
Korea
.
7.
Wen Xie Xu, Tong Mook Kang, Ki
Whan Kim: Effects of purinergic agonists on the contractility of
antral circular muscle in guinea pig stomach. The International
Symposium “Smooth Muscle” February 17, 1995,
Seoul
Korea
.
8.
Wen Xie Xu, et al. Effects of
purinergic agonists on mechanical and electrical activity of
antral circular muscle of guinea-pig stomach. Federation Meeting
of Korean Basic Medical Scientists, June 15-16, 1995,
Seoul
Korea
.
9.
Wen Xie Xu, et al. Effect of
stretch on Barium channel currents recorded from the antral
circular myocytes of guinea-pig. 47th Annual Meeting of
the Korean Physiological Society, October 19-20, 1995,
Seoul
Korea
.
10.
Wen Xie Xu, Tong Mook Kang and Ki
Whan Kim: Effects of purinergic agonists on the contractility and
membrane potential of antral circular muscle in guinea-pig
stomach. Joint Symposium with the Physiological Society of the
United Kingdom
, April 4-5, 1995,
Seoul
Korea
.
11.
Wen Xie Xu, et al. Effect of
stretch on Barium channel currents recorded from the antral
circular myocytes of guinea-pig. Annual Meeting of the Korean
Smooth Muscle Society, May 10, 1996,
Seoul
Korea
.
12.
Wen Xie Xu, et al.
Volume/stretch-sensitive chloride current in guinea-pig antral
gastric myocytes. Annual Meeting of the Korean Smooth Muscle
Society, May 10, 1996,
Seoul
Korea
.
13.
Wen Xie Xu, et al.
Enhancement of the L-type calcium current by mechanical
stretch in antral circular myocytes of guinea-pig stomach. Annual
Meeting of the Korean Smooth Muscle Society, June 20, 1997,
Seoul
Korea
.
14.
Wen Xie Xu, et al. Role of the
actin cytoskeleton on osmotic swelling-induced increase of L-type
calcium channel current in guinea-pig gastric myocytes. Federation
Meeting of Korean Basic Medical Scientists, April 24-25, 1997,
Seoul
Korea
.
15.
Jing-Yu Jin, Ying Li, Nan-Ge Jin,
Wen-Xie Xu and Zai-Liu Li: Effects of nitric oxide on electrical
and motility of gastric antrial circular muscle in various
animals. Annual Meeting of the Korean Smooth Muscle Society, May
22, 1998,
Seoul
Korea
.
16.
Wen Xie Xu et al. Inhibitory
effect of volumedial hypothalamus on gastric electrical and
mechanical actions and role of nitric oxide in this effect. Asian
chapter of international college of psychosomatic medicine (ACIPCM)
biannual meeting. Oct.30, 1998,
Seoul
Korea
.
17.
Wen Xie Xu and Zai Liu Li. Effect
of Nitric oxide on Gastric Antral Circular Muscle Motility and
It’s Mechanism in guinea-pig. 51th
Annual Meeting of the Korean Physiological Society,
October 15-16, 1999,
Seoul
Korea
.
18.
Wen Xie Xu, et al. Intracellular
calcium concentration modulated by C-type Natriuretic peptide in
rabbit atrial myocytes.52th Annual Meeting of the
Korean Physiological Society, October 20-21, 2000, Seoul Korea.
19.
Xun Cui, Wen Xie Xu, et al.
Cyclic AMP-elevating agents inhibit atrial ANP Release:
Ca2+-independent inhibition of the release.52th Annual
Meeting of the Korean Physiological Society, October 20-21, 2000,
Seoul
Korea
.
20.
Xun Cui, Wen Xie Xu et al.
Ca2+-independent inhibition of ANP release by cAMP-elevating
agents. FASEB 2001,
A146: 161.7.
21.
Wen Jin Fu, Xun Cui, Wen Xie Xu
et al. Jin Fu Wen, Xun Cui et al. Distinct roles for L- and T-type
Ca2+ channel in the regulation of atrial ANP release. FASEB.
2001, A447: 404.1.
22.
Wen Xie Xu, Xun Cui et al.
Inhibitory effect of C-type natriuretic peptide on spontaneous
contraction of gastric circular smooth muscle: cyclic GMP-dependent
mechanism. FASEB
2001, A827: 659.1.
23.
Meng Yang, Jia Bin Shun, Hai Feng
Zheng, Wen Xie Xu. Role of Arachidonic Acid in Hyposmotic Membrane
Stretch-Induced Increase of Calcium-Activated Potassium Current in
Gastric Myocytes. The First International Conference of Chinese
Physiological Scientists, July 14-17, 2004
Beijing
,
China
.
Published
Mauscripts:
1.
Sheong Chul An,Wen Xie Xu, Sung Joon Kim, Insuk
So, Tong Mook Kang, Ki Whan Kim :
Effect of purinergic agonist on mechnical and electrical
activities of gastric smooth muscle of guinea-pig. J.
Smooth Muscle Res. 31: 60-63, 1995.
2.
Wen Xie Xu, Sung Joon Kim, Insuk
So, Tong Mook Kang, Ki Whan Kim : Effect of stretch on calcium
channel currents recorded from the antral circular myocytes of
guinea-pig stomach. Pflugers
Arch. 432: 159-164, 1996.
3.
Wen Xie Xu, Sung Joon Kim, Insuk
So, Tong Mook Kang, Ki Whan Kim :
Role of actin microfilament in osmotic stretch-induced
increase of voltage-operated calcium channel current in guinea-pig
gastric myocytes. Pflugers
Arch. 434: 502-504, 1997.
4.
Wen Xie Xu, Sung Joon Kim, Insuk
So, Tong Mook Kang, Ki Whan Kim : Volume-sensitive chloride
current activated by hyposmotic swelling in antral gastric
myocytes of the guinea-pig. Pflugers Arch. 435: 9-19, 1997.
5.
Wen Xie Xu, Sung Joon Kim, Insuk
So, Tong Mook Kang, Ki Whan Kim :
Effects of arachidonic acid on the calcium channel current
(IBa)and on the osmotic stretch-induced increase of IBa
in guinea-pig gastric myocytes. Korean
J. Physiol. Pharmacol.
1: 435-443, 1997.
6.
Wen Xie Xu et al. Evidence for
Adenosine Triphosphate (ATP) as an Excitatory Neurotransmitter in
Guinea-pig Gastric Antrum. The
Korean J Physiol & Pharmacol, 1999, 3: 165-174.
7.
Xu Wen Xie,
Li Ying, Li Zhai Liu. Effects of
different kinds of stretch on voltage-dependent calcium current in
antral circular smooth muscle cells of the guinea-pig. Acta
Physiologica Sinica, 2000, 52: 69-74.
8.
Li Ying, Xu Wen Xie, Li Zai Liu.
Effects of nitroprusside, 3-morpholino-sydnonimine, and spermine
on calcium-sensitive potassium currents in gastric antral circular
myocytes of guinea pig. Acta Pharmacol Sin, 2000, 21: 571-576.
9.
Jin Nan-Ge, Li Ying, Xu Wen Xie
and Li Zai-Liu: Exogenous nitric oxide directly inhibits antral
circular muscle motility of rat sromach in vitro. World chinese
journal of digestion,6(3): 188-191.1998
10.
Jin Jing Yu , Xu Wen Xie et al.
Effect of nitric oxide on electric and mechanical activities of
gastric antral circular muscles in guinea pigs. Acta
Pharmacol Sin, 2000, 21: 369-373.
11.
Piao Lin, Li Ying, Li Lin, Xu Wen
Xie. Increment of calcium-activated and delayed rectifier
potassium current by hyposmotic swelling in gastric antral
circular myocytes of guinea pig. Acta
Pharmacol Sin, 2001, 22: 566-572。
12.
Lin Piao, Ying Li, Lin Li, Nan Ge
Jin, Zai Liu Li, Wen Xie Xu. The involvement of calcium
mobilization in the calcium-activated potassium currents actvated
by hyposmotic swelling in gastric antral circular myocytes of the
guinea-pig. Jpn J Physiol,
2001, 51: 223-230。
13.
XUN CUI, JIN FU WEN, YINGYU JIN,
WEN XIE XU, SUNG ZOO KIM, SUHN HEE KIM, HO SUB LEE, AND KYUNG WOO
CHO. Protein kinase-dependent and Ca2+-independent cAMP
inhibition of ANP release in beating rabbit atria. Am J Phiol
Reguatory Integrative comp Phyiol 2002, 282:R1477-1489.
14.
Lin Li, Nan-Ge Jin, Lin Piao,
Ming-Yu Hong, Zheng-Yuan Jin, Ying Li, Wen-Xie Xu. Hyposmotic
membrane stretch potentiated muscarinic receptor agonist-induced
depolarization of membrane potential in guinea-pig gastri
myoccytes. World J Gastroenterol 2002, 8 (4): 724-727.
15.
Yong Chun Yu, Hui Shu Guo, Piao
Lin, Li Lin, Lee Zai Liu, Xu Wen-Xie. Intracellular calcium
involved in muscarinic currents increased by hyposmotic membrane
stretch in gastric myocytes of guinea-pig. Acta
Pharmacol Sin 2002, 23:
961-1056.
16.
Yong Chun Yu, Ying Li, Lin Piao,
Lin Li, Zhai Liu Li, Wen Xie Xu. The role of calcium mobilization
in sodium nitroprusside-induced increase of calcium-activated
potassium currents in gastric antral circular myocytes of
guinea-pig. Acta Pharmacol Sin 2003, 24: 819-825.
17.
Zuo Yu Wang, Yong Chun Yu, Yi
Feng Cui, Lin Li , Hui Shu Guo, Zai Liu Lee, Wen Xie Xu. Role
of actin microfilament in hyposmotic membrane stretch-induced
increase of muscarinic current in guinea-pig gastric myocytes. Acta Physiologica Sinica
2003, 55: 177-182.
18.
CUI Yi-Feng , JIN Hai, GUO Hui-Shu,
LI Lin, YU Yong-Chun, XU Wen-Xie. Effect
of unsaturated fatty acid on muscarinic current in guinea pig
gastric myocytes. Acta
Pharmacol Sin
2003, 24: 283-288.
19.
Cui Yi-Feng , Li Lin ,
Yu Yong-Chun, Jin Zheng-Yuan , Lee Zai-Liu Xu Wen-Xie. Role of unsaturated fatty acids in the
process of hyposmotic membrane stretch enhanced-muscarinic current
in guinea pig smooth muscle cells. Acta
Physiologica Sinica，2003，55：96-100.
20.
Hui-Shu Guo,
Zheng-Jin,, Zheng-Yuan Jin, Zhe-Hao Li,
Yi-Feng Cui, Zuo-Yu Wang, Wen-Xie Xu.
Comparative study in the effect of
C-type natriuretic peptide on gastric motility in various animals. World J Gastroenterol 2003;
9(3): 547-552.
21.
GUO Hui-Shu, CUI Xun, CUI
Yong-Gen , Kim Sung-Zoo, CHO Kyung-Woo,
LI Zai-Liu, Xu Wen-Xie.
Inhibitory effect of C-type natriuretic
peptide on spontaneous contraction in gastric antral circular
smooth muscle of rat1. Acta
Pharmacol Sin 2003,
24: 1021-1026
22.
Hui-Shu Guo, Zheng-Xu Cai,
Hai-Feng Zheng, Xiang-Lan Li, Yi-Feng Cui, Zuo-Yu Wang, Wen-Xie Xu.
The role of calcium-activated potassium currents in CNP-induced
relaxation of gastric antral circular smooth
muscle in guinea-pigs World
J Gastroenterol, 2003, 9(9): 2054-2059.
23.
Li Xiang Lan, Zheng Hai Feng，Jin
Zheng Yuan，Yang
Meng，Li
Zhai Liu，Xu
Wen Xie. Effect of actin microfilament on potassium current in
guinea pig gastric myocytes. World J Gastroenterol
2004, 10: 3303-3307
24.
Jin Zheng, Guo
Hui-Shu, Hong Ming Yu, Li Xiang Lan,
Xu Wen-Xie. Effects of purinergic analogues on
spontaneous contraction and electrical activities of gastric
antral circular muscle in guinea-pig.
Acta Physiologica
Sinica, 2004, 56: 678-684.
25.
Piao WH, Song XG, Liu MC, He Y,
Zhang HH, Xu WX, Li ZL, Zhang HQ, Ling SG, Wang GQ. Cloning,
expression, and purification of HLA-A2-BSP and beta
-2m
in Escherichia coli. Protein Expr
Purif. 2004 Jun;35(2):210-7.
26.
Piao
WH, He
Y, Xi
HL, Sun
XT, Zhang
HH, Xu
JH, Zhao
H, Xu
WX, Li
ZL, Wang
GQ.Construction
of HLA-A2-peptide tetramer and application in HBV/HCV infection. Zhonghua
Yi Xue Za Zhi. 2004，8:1818-22.
27.
ZHENG Hai-Feng, LI Xiang-Lan, JIN Zheng-Yuan, SUN Jia-Bin, LI Zai-Liu,
XU Wen-Xie. Effect of unsaturated fatty acid on calcium-activated
potassium current in guinea pig gastric myocytes. World J
Gastroenterol 2005, 11: 672-675.
28.
Meng Yang, Xing Lan
Li , Hui Ying XU , Jia Bin Sun,
Bin Mei , Hai Feng Zheng, Lian Hua Piao,
Zhai Liu Li, Wen Xie Xu Role
of Arachidonic
acid in
hyposmotic membrane stretch-induced increase in calcium-activated
potassium current in gastric myocytes. Acta
Pharmacol Sin, 2005, 26：1233-1242.
29.
Li CH, Piao DM, Xu WX, Yin ZR, Jin JS,
Shen ZS. Morphological and serum
hyaluronic acid, laminin and type IV collagen changes in
dimethylnitrosamine-induced hepatic fibrosis of rats. World J
Gastroenterol. 2005, 11: 7620-4.
30.
Kim YC, Sim JH, Lee SJ, Kang TM,
Kim SJ, Kim SR, Youn SJ, Lee SJ, Xu WX, Kim KW. Regulation of
L-type calcium channel currents by somatostatin in guinea-pig
gatric myocytes. KJPP, 2005, 9: 103-108.
31.
Chun-hui Li, Zong-wei Yang, Zheng-ri Yin, Zheng Jin,
De-gang Xing, Lian Hua Piao, Yong-chul Kim, Wen-xie Xu.
Relationship between atrial natriuretic peptide-immunoreactive
cells and microvessels in rat gastric mucosa. Acta Pharmacol Sin，2006,
27: 205-11.
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