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 徐晓明简介：1975年毕业于上海第二医科大学，1985年获上海第二医科大学硕士，1990年获美国俄亥俄州立大学博士，1991至1994年在美国迈阿密大学医学院从事博士后研究，1994至2001年任美国圣路易斯大学医学院解剖和神经生物学系助理教授、副教授，2001年6月至今任美国路易维尔大学医学院神经外科系副教授、教授,
James R. Petersdorf 讲座教授及路易维尔大学优秀学者。1999年起任上海第二医科大学（现上海交通大学医学院）神经生物学实验室客座教授、博士生导师。2005年起任成都军区昆明总医院客座教授。曾获俄亥俄州立大学校长奖学金、Daniel
Heumann 国际学者、美国神经创伤学会Michael
Goldberger奖、Christopher
Reeve自由研究奖等。近十多年来，连续获得美国国立健康研究院（NIH）及国际脊髓损伤研究基金会等多项资助。目前任美国NIH
CNNT评审组评委。迄今已在国外有影响的杂志，包括Nature
Neuroscience, Journal of Neuroscience, Annals of Neurology, and
FASEB Journal等，发表论文六十余篇。研究方向：脊髓损伤、移植和再生。
Selected
peer-reviewed publications (Selected from over 80 peer-reviewed research articles)
Xu
XM,
Martin GF. Developmental plasticity of the rubrospinal tract in
the North American opossum. J Comp Neurol, 279:368-381, 1989.
Xu
XM,
Martin GF. The response of rubrospinal neurons to axotomy in the
adult opossum, Didelphis virginiana. Exp Neurol, 108:46-54,
1990.
Xu
XM,
Martin GF. Evidence for new growth and regeneration of cut axons
in developmental plasticy of the rubrospinal tract in the North
American opossum. J Comp Neurol, 313:103-112, 1991.
Martin
GF, Ghooray G, Ho R, Pindzola RR, Xu
XM. The origin of serotoninergic projections to the
lumbosacral spinal cord at different stages of development in the
North American opossum. Develop Brain Res, 58:203-213, 1991.
Xu
XM,
Martin GF. Ipsilaterally projecting rubrospinal neurons in adult
and developing opossum. Anat Rec, 231:538-547, 1991.
Xu
XM,
Martin GF. The response of rubrospinal neurons to axotomy at
different stages of development in the North American opossum. J
Neurotrauma, 9:93-195, 1992.
Martin
GF, Pindzola RR, Xu
XM. The origins of descending projections to the lumbar spinal
cord at different stages of development in the North American
opossum. Brain Res Bull, 30:303-317, 1993.
Xu
XM,
Guenard V, Kleitman N,
Bunge
MB
. Axonal regeneration into Schwann cell-seeded guidance channels
grafted into transected adult rat spinal cord. J Comp Neurol,
351:145-160, 1995.
Xu
XM,
Guenard V, Kleitman N,
Bunge
MB
. A combination of BDNF and NT-3 promotes supraspinal axonal
regeneration into Schwann cell grafts in adult rat thoracic spinal
cord. Exp Neurol 134:261-272, 1995.
Martin
GF, Ghooray GT, Wang XM, Xu XM. Plasticity of descending spinal pathways in developing
mammals. Adv Neur Sci, 2:169-204, 1995.
Chen
AQ, Xu XM,
Kleitman N,
Bunge
MB
. Methylprednisolone administration improves axonal regeneration
into Schwann cell grafts in transected adult rat thoracic spinal
cord. Exp Neurol, 138:261-276, 1996.
Oudega M, Xu XM,
Guenard V, Kleitman N, Bunge MB. A combination of insulin-like
growth factor-I and platelet-derived growth factor enhances
myelination but diminishes axonal regeneration into Schwann cell
grafts in the adult rat spinal cord. Glia, 19:247-258, 1997.
Liu
XZ, Xu XM, Hu
R, Cheng D, Zhang SX, McDonald JW, Dong HX, Wu YJ, Fan GS, Jacquin
ME, Hsu CY, Choi DW. Neuronal and glial apoptosis after traumatic
spinal cord injury. J Neurosci, 17:5395-5406, 1997.
Xu XM,
Chen A, Guenard V, Kleitman N,
Bunge
MB
. Bridging Schwann cell transplants promote axonal regeneration
from both the rostral and caudal stumps of transected adult rat
spinal cord. J Neurocytol, 16:1-16, 1997.
Xu J, Fan GS, Chen SW, Wu YJ, Liu XZ, Xu XM, Hsu CY. Methylprednisolone reduced TNF-a
expression and
NF-
kb
activation caused by spinal cord injury in rat. Molec Brain Res,
59:135-142, 1998.
Gianino S, Stein SA, Li H, Lu X, Biesiada E, Ulas J, Xu
XM. Postnatal growth of corticospinal axons in the spinal cord
of developing mice. Devel Brain Res, 112:189-204, 1999.
Xu
XM,
Zhang SX, Li H, Aebischer P,
Bunge
MB
. Regrowth of axons into the distal spinal cord through a Schwann
cell-seeded mini-channel implanted into hemisected adult rat
spinal cord. Eur J Neurosci, 11:1723-1740, 1999.
Thomas CK, Esipenko V, Xu
XM, Madsen PW, Gordon T. Innervation and properties of the rat
FDSBQ muscle: an animal model to evaluate voluntary muscle
strength after incomplete spinal cord injury. Exp Neurol,
158:279-289, 1999.
Yan P, Xu J, Li Q, Chen SW, Kim GM, Hsu CY, Xu
XM. Glucocorticoid receptor expression in the spinal cord
after traumatic injury in adult rats. J Neurosci 19:9355-9363,
1999.
Bamber NI, Li HY, Aebischer P, Xu XM. Fetal spinal cord tissue in guidance channels promotes
longitudinal axonal growth in the partially lesioned adult rat
spinal cord. Neur Plastic, 6:103-121, 1999.
Kanellopoulos GK, Xu
XM, Hsu CY, Lu XB, Sundt TM, Kouchoukos NK. White matter
injury in spinal cord ischemia: Protectection by AMPA/kainite
glutamate receptor antagonism. Stroke, 31:1945-1952, 2000.
Kim ES, Li H, McCulloch PF, Morrison LA, Yoon KW, Xu
XM. Spatial and temporal patterns of transneuronal labeling in
CNS neurons after injection of pseudorabies virus into the sciatic
nerve of adult rats. Brain Res, 857:41-55, 2000.
Ahmed
SH, He YY, Nassief A, Xu J, Xu XM, Hsu CY. Effects of lipopolysaccharide priming on acute
ischemic brain injury. Stroke, 31:193-199, 2000.
Iannotti C, Lu X, Lu P, Xu
XM. Neural stem cell transplantation in the repair of spinal
cord injury. Prog Natural Sci, 7:490-502, 2001.
Xu J, Kim G-M, Ahmed SH, Xu J, Yan P, Xu XM, Hsu CY. Glucocorticoid receptor-mediated suppression of AP-1
activation and matrix metalloproteinase expression after spinal
cord injury. J Neurosci, 21:92-97, 2001.
Bamber NI, Li H, Lu X, Oudega M, Aebischer P, Xu
XM. Neurotrophins BDNF and NT-3 promote axonal re-entry into
the distal host spinal cord through Schwann cell-seeded
mini-channels. Eur J Neurosci, 13:257-268, 2001.
Yan P, Li Q, Kim G-M, Xu J, Hsu CY, Xu XM. Cellular localization of tumor necrosis factor-a
following acute spinal cord injury in adult rats. J Neurotrauma,
18:563-568, 2001.
Xu J, Kim G-M, Chen S, Yan P, Ahmed SH, Ku G, Beckman JS, Xu
XM, Hsu CY. iNOS and nitrotyrosin expression after spinal cord
injury. J Neurotrauma, 18:523-532, 2001.
Warden P, Bamber NI, Li H, Esposito A, Ahmad KA, Hsu CY, Xu
XM. Delayed glial cell death following Wallerian degeneration
in white matter tracts after spinal cord dorsal column cordotomy
in adult rats. Exp Neurol, 168:213-224, 2001.
Kim G-M, Xu J, Xu J, Song S-K, Yan P, Ku G, Xu
XM, Hsu CY. Tumor necrosis factor receptor deletion reduces
nuclear factor-kb
activation, cellular inhibitor of apoptosis protein 2 expression,
and functional recovery after traumatic spinal cord injury. J
Neurosci, 21:6617-6625, 2001.
Kim E-S, Kim G-M, Lu X, Hsu CY, Xu XM. Neural connection in the adult rat CNS after spinal cord
injury – A study using fast blue and the bartha strain of
Pseudorabies virus. J Neurotrauma, 19:787-800, 2002.
Iannotti CI, Li H, Stemmler M, Perman WH, Xu
X-M. Identification of regenerative tissue cables using in
vivo MRI after spinal cord hemisection and Schwann cell bridging
transplantation. J Neurotrauma, 19:1543-1554, 2002.
Yan P, Liu N, Kim G-M, Xu J, Xu J, Li
Q, Hsu CY, Xu X-M. Expression
of the type 1 and type 2 receptors for tumor necrosis factor after
traumatic spinal cord injury in adult rats. Exp Neurol
183:286-297, 2003.
Iannotti
C, Li H, Yan P, Lu X, Wirthlin L, Xu
X-M. Glial cell line-derived neurotrophic factor (GDNF)-enriched
bridging transplants promote propriospinal axonal regeneration and
enhance myelination after spinal cord injury. Exp Neurol
183:379-393, 2003.
Chau
CH, Shum
DKY, Li
H, Lu X, Liu YY, Wirthlin L, Chan YS, Xu X-M (2004) Chondroitinase ABC
enhances axonal regrowth through Schwann cell-seeded guidance
channels after spinal cord
injury. FASEB J. 18: 194-196.
Sivasankaran,
R.,
Pei
, J., Wang, K.C., Zhang, Y.P., Shields, C.B., Xu,
X.-M.* and He, Z.* (2004) Protein kinase C mediates inhibitory
effects of myelin and chondroitin sulfate proteoglycans on axonal
regeneration. Nat. Neurosci. 7:261-268. (* co-corresponding
authors)
Liu
NK, Han S, Lu P-H, Xu X-M (2004)
Upregulation of annexins I, II and V following traumatic
spinal cord injury in adult rats. J
Neurosci Res, 77:391-401.
Zhang
YP, Iannotti C, Han Y, Shields LBE, Burke DA, Xu X-M,
Shields CB (2004) Dural closure, cord approximation, and clot
removal enhancing tissue sparing in a novel laceration spinal cord
injury model? J Neurosurg
100 (4):343-352.
Iannotti
C, Zhang YP, Shields CB, Han Y, Burke DA, Xu
X-M (2004) A neuroprotective role of glial cell line-derived
neurotrophic factor following moderate spinal cord contusion
injury. Exp Neurol, 189:317-332.
Zhang
KH, Xiao H-S, Lu P-H, Shi J, Li G-D, Wang Y-T, Zhang X, Xu X-M (2004) Differential gene expression after complete spinal cord
transection in adult rats: An analysis focused on a sub-chronic
post-injury stage. Neuroscience,
128:375-388.
Chau
CH, Shum DKY, Xu X-M
(2004) Combinatorial strategies towards spinal cord repair:
enhancement of the Schwann cell bridge and modification of the graft-host
interface.
Preclinica, 2:409-415.
Hu
J-G, Fu S-L, Zhang K-H, Li Y, Ying L, Lu P-H, Xu X-M (2004)
Differential gene expression in neural stem cells and
oligodendrocyte precursor cells: A cDNA microarray analysis.
J
Neurosci Res, 78:637-646.
Cao
Q, Zhang YP, Iannotti C, DeVries WH, Xu
X-M, Shields CB, Whittemore SR (2005) Functional and
electrophysiological changes after graded traumatic spinal cord
injury in adult rat. Exp
Neurol, 191:S3-16.
Hsu
J-Y, Stein SA, and Xu
X-M (2005)
Temporal
and spatial distributions of growth-associated molecules and
astroglial cells in the rat corticospinal tract during development
J Neurosci Res 80:330-340.
Fu
S, Ma Z, Yin L, Iannotti C, Lu P, and Xu
X-M (2005) Region-specific growth properties and trophic
requirements of brain- and spinal cord-derived embryonic neural
precursor cells. Neurosci 135:851-862.
Cao Q, Xu X-M,
DeVries WH, Enzmann GU, Ping PP, Tsoulfas P, Wood PM, Bunge MB,
and Whittemore SR (2005) Functional recovery in traumatic spinal
cord injury after transplantation of multineurotrophin-expressing
glial-restricted precursor cells. J
Neurosci 25:6947-6957.
Hsu
J-YC and Xu X-M
(2005) Early axonal growth and astroglial response after spinal
cord hemisection and Schwann cell-seeded guidance channel
implantation in adult rats. J
Neurosci Res 82:472-483.
Iannotti C, Zhang YP, Han Y, Burke DA, Shields BE, Xu
X-M and Shields CB (2006) Dural repair reduces connective
tissue scar invasion and cystic cavity formation following acute
spinal cord laceration injury in the rat. J. Neurotrauma (Accepted).
Oudega M, Xu
X-M (2006) Schwann cell transplantation for repair of the
adult spinal cord. J
Neurotrauma (Invited review, accepted).
Wang X-F, Huang L-D, Yu P-P, Hu J-G, Yin L, Wang L, Xu
X-M*, Lu P-H* (2006) Upregulation of type
I
interleuke-1 receptor after traumatic spinal cord injury in adult
rats. Acta Neuropathol (Accepted) (*
co-corresponding authors)
Liu
NK, Zhang YP, Titsworth WL,
Jiang X, Han S, Lu PH, Shields CB and Xu X-M (2006) A
Novel Role of Phospholipase A2 in Mediating Spinal Cord
Secondary Injury. Annal
Neurol (Accepted)
Ongoing
Research Support
1R01
NS52290 (Xu)
7/1/05-6/30/10
NIH/NINDS
PKC
inhibition-mediated spinal cord regeneration
The
major goal of this project is to investigate protein kinase C (PKC)
inhibition-mediated axonal regeneration and recovery of functions
of long sensory and motor pathways following spinal cord injury.
R01
NS36350 (Xu)
07/15/03-04/30/07
NIH/NINDS
Schwann cells, neurotrophins and spinal cord
regrowth
The
major goal of this project is to investigate the effects and
mechanisms of GDNF on axonal regeneration and recovery of function
in a model of spinal cord hemisection and Schwann cell-seeded
guidance channel transplantation.
Role:
PI
#04-16
(Xu)
1/15/05-1/14/08
Kentucky
Spinal Cord & Head Injury Research Trust
A
novel role of PLA2 in mediating spinal cord secondary
injury
The
major goal of this project is to investigate the pathological role
and underlying mechanism of phospholipase A2 in
mediating spinal cord secondary injury.
Role:
PI
Not
numbered (Xu)
10/01/03-09/30/05
Daniel
Heumann Fund for Spinal Cord Research
Combination of glycosaminoglycan-modulation and neurotrophin infusion
strategies in SC regeneration
The
major goal of this project is to examine the attractiveness of
soluble forms of heparin sulfates (HS) to growing axons in a model
of spinal cord hemisection and Schwann cell bridge
transplantation.
Role:
PI
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