Huang-Tian Yang, M.D., Ph.D.

CURRENT APPOINTMENTS:

Principal Investigator

Head, Laboratory of Molecular Cardiology

Institute of Health Science

Shanghai Institutes for Biological Sciences

Chinese Academy of Sciences and

Shanghai Jiao Tong University School of Medicine

              OFFICE ADDRESS:

225 Chong Qing Nan Rd. Build. #1, Rm 613
Shanghai 200025, China
Phone:+86-21-63852793(O); +86-21-63852773(L)
Fax: +86-21-63852593

e-mail: htyang@sibs.ac.cn

MEMBERSHIP IN PROFESSIONAL SOCIETIES

Chinese Association for Physiological Sciences (Council member)

The International Society for Heart (member)

The International Society for Heart Research-China Section (Council member)

Chinese Society of Medicine Association of Cardiovascular Sciences (member)

Chinese Society of High Altitude Medicine (Council member)

Chinese Association of  Pathophysiology, Cardiovascular Sciences (Council member)

Chinese Society for Cell Biology (member)

Shanghai Society for Physiological Sciences (Council member)

Japanese Society of Pharmacology

PRESENTATION ON SCIENTIFIC ACTIVITIE

EDITORIAL BOARD MEMBERSHIPS

Acta Physiologica Sinica

Zhongguo Shengwuxue Wenzhai

Regular Review for the following journals:

Acta Pharmacol. Sinica

Cell Research

Chinese Journal of Applied Physiology

Chinese Journal of Cell Biology

Chinese Science Bulletin

Journal of Biosciences

Journal of Biotechnology

Journal of Molecular and Cellular Cardiology

Life Science

Neuroscience Letters

ACADEMIC HONORS

Awards:

2^nd Award of Science and Technology Progress in Nantong （1990）

Weihala Scholarship (1993-1995)

Fellows Award for Research Excellence from National Institutes of Health (2001)

2003-2004年度上海市科教系统“三八红旗手” (2005)

MAIN PUBLICATIONS

1.       Yang, Huang-Tian., Yang, Yu-Lin. Effect of naphthylmethyl isoquinoline on the isolated guinea pig myocardium. Acta Pharmaceutica Sinica. 25(7): 485-489, 1990

2.       Yang, Huang-Tian., Yang, Yu-Lin., Peng, Si-Xun. and Huang, Wen-Long. Hypotensive effect of naphthylmethyl isoquinoline. Acta Pharmaceutica Sinica. 25(7): 551-554, 1990

3.       Kohi M., Yang HT., Endoh M. Myocardial a 1A -adrenoceptor subtypes in rabbit: differentiation by a selective antagonist, HV723. Eur. J. Pharmacol. 250: 95-101, 1993

4.       Endoh M., Yang HT., Kohi M., Norota I., Takanashi M. Myocardial a 1A -adrenoceptors mediating the positive inotropic effect in the rabbit ventricular myocardium: WB4101- and (+)-niguldipine-sensitive receptors belong to different subclasses. J Mol Cell Cardiol. 25 (Suppl. II): S29, 1993

5.       Huang-Tian Yang and Masao Endoh. Dissociation of the methoxamine-induced positive inotropic effect and phosphoinositide hydrolysis in rabbit ventricular myocardium: comparison with phenylephrine and alpha-1 adrenoceptor subtype involved. J. Pharmacol. Exp. Ther. 269(2): 732-742, 1994

6.       Huang-Tian Yang, Ikuo Norota, Masao Endoh. Influence of WB4101, (+)-niguldipine and chlorethylclonidine (CEC) on the methoxamine-induced positive inotropic effect (PIE) and phosphoinositide (PI) hydrolysis in rabbit ventricular muscle. Japan . J. Pharmacol. 64(suppl I): 264p, 1994

7.        Huang-Tian Yang, Ikuo Norota and Masao Endoh. Positive inotropic effect and acceleration of phosphoinositide hydrolysis by methoxamine. Heart 26(Suppl. 4): 24-28, 1994

8.       Masao Endoh, Ikuo Norota, Huang-Tian Yang. Endothelin receptor subtypes mediating the positive inotropic effect and hydrolysis of PI in rabbit ventricular muscle: influence of a selective ETA antagonist FR 139317 on response induced by ET-1 and ET-3. J Mol Cell Cardiol. 26(11): CCXXXV(152), 1994

9.       杨黄恬，杨毓麟．中国药理学通报. 心脏alpha-1肾上腺素受体研究进展 ─ 正性肌力作用机制及受体亚型．10:411-414, 1994

10.    Huang-Tian Yang and Masao Endoh. Differential antagonistic action of tamsulosin on the positive inotropic effect and the acceleration of phosphoinositide (PI) hydrolysis mediated by alpha1-adrenoceptors in rabbit ventricular muscle. Japan . J. Pharmacol. 67(Suppl I): 168p, 1995

11.   Huang-Tian Yang, Ikuo Norota, Yi Zhu and Masao Endoh. Mechanisms for the inhibitory action of methoxamine on the receptor-mediated inotropic response. Heart 27(Suppl. 2): 16-19, 1995

12.    M. Endoh, A. Ishihata, H.-T. Yang, I. Norota, H. Morita and J. Kimura. Regulation of phosphoinositide hydrolysis, ion channels and contraction by angiotensin II in comparison with endothelin, and a1-adrenoceptor agonists in myocardial cells. Heart and Vessels, Suppl. 10: 13, 1995

13.    H.-T. Yang, I. Norota, Y. Zhu and M. Endoh. Selective inhibition by methoxamine via a 1A -adrenoceptor of the positive inotropic effect of endothelin in rabbit ventricular myocardium. Heart and Vessels, Suppl. 10: 30, 1995

14.    Huang-Tian Yang, Ikuo Norota, Yi Zhu and Masao Endoh. Methoxamine-induced inhibition of the positive inotropic effect of endothelin via a1-adrenoceptors in the rabbit heart. Eur. J. Pharmacol. 296(1): 47-54, 1996

15.    Masao Endoh, Ikuo Norota, Huang-Tian Yang, Shinji Fujita and Masahiro Takanashi. Positive inotropic effect and the hydrolysis of phosphoinositide induced by endothelin -3 in rabbit ventricular myocardium: inhibition by a selective antagonist of ETA receptors, FR139317. J. Pharmacol. Exp. Ther. 277(1): 61-71, 1996

16.     Huang-Tian Yang and Masao Endoh. Effect of BMY 7378, a selective antagonist of the a1D-adrenoceptors in the rabbit. Jap J Pharmacol. 71(suppl. I): 137P,  1996

17.    Yi Zhu, Huang-Tian Yang and Masao Endoh. Different mechanisms responsible for the inhibitory action of endothelins on the chronotropic and inotropic responses to b-adrenergic stimulation. Jap J Pharmacol. 71(suppl. I): 138P (P-317), 1996

18.    Huang-Tian Yang & Masao Endoh. (")-Tamsulosin, an a 1A -adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart. Eur. J. Pharmacol. 312(3): 281-291, 1996

19.    Huang-Tian Yang, Yi Zhu & Masao Endoh. Species-dependent difference in the endothelin-3-induced inotropic effect in mammalian ventricular muscles: relation to specific binding sites and phosphoinositide hydrolysis Circulation 94(8): I-723 (4231), 1996

20.    Huang-Tian Yang & Masao Endoh. Does a1D-adrenoceptor contribute to the contractile response in the rabbit ventricular myocardium: study with BMY 7378. Jap J Pharmacol. 73 (Suppl. I): 237P, 1997

21.    Yi Zhu, Huang-Tian Yang and Masao Endoh:  Pertussis toxin sensitive G protein mediates the inhibitory action of endothelin-1 on the positive inotropic response to b stimulation in dog ventricular myocardium. Jap J Pharmacol. 73 (Suppl. I): 236P, 1997

22.   Huang-Tian Yang, Yi Zhu and Masao Endoh. Species-dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin -3 in relation to specific binding sites in mammalian ventricular myocardium. Br. J. Pharmacol. 120: 1497 - 1504, 1997

23.   Yi Zhu, Huang-Tian Yang and Masao Endoh: Negative chronotropic and inotropic effects of endothelin isopeptides in mammalian cardiac muscle. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H119 - H127 , 1997

24.    Y. Zhu, H.-T. Yang & M. Endoh: Does nitric oxide contribute to the negative choronotropic and inotropic effects of endothelin -1 in the heart? Eur. J. Pharmacol. 332: 195-199, 1997

25.   Huang-Tian Yang & Masao Endoh. Pharmacological evidence for a1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br. J. Pharmacol. 122: 1541-1550, 1997

26.   Huang-Tian Yang & Masao Endoh. Effects of endothelin-1 on contractility in isolated rabbit ventricular cardiomyocytes loaded with indo-1. Jap J Pharmacol. 111(1): p35, 1998

27.    Masao Endoh, Shinji Fujita, Huang-Tian Yang, M.A. Hassan Talukder, Jun Maruya and Ikuo Norota. Endothelin: recetpor subtypes, signal transduction, regulation of Ca²⁺ transients and contractility in rabbit ventricular myocardium. Life Sciences. 62(17/18): 1485-1489, 1998

28.    Endoh, M., Maruya, J., Norota, I. , Yang, H.-T., Talukder, M.A. Hassan, Watanabe, T., Sakurai, K. Cardiac effects of endothelin: difference between signal myocytes and intact ventricular myocardium. Current Topics in Pharmacology 4: 293-300, 1998

29.    Huang-Tian Yang, Kiyoharu sakurai, Hiromi Sugawara, Tomoo Watanabe, Ikuo Norota & Masao Endoh. Contribution of Na+/Ca²⁺ exchange to the endothelin-1-induced increases in  Ca²⁺ transient and contractility in rabbit ventricular cardiac myocytes: pharmacological analysis with KB-R7943. Br. J. Pharmacol. 126(8): 1785‑1795, 1999

30.    Michail D. Stern, Long-Sheng Song, Heping Cheng, James S. K. Sham, Huang-Tian Yang, Kenneth R. Boheler and Eduardo Rios. Local control models of cardiac excitation-contraction coupling: a possible role for allosteric interactions between ryanodine receptors. J. Gen. Physiol. 113:469-489, 1999

31.   Yi Zhu, Huang-Tian Yang , Lydia ONeill, Edward G. Lakatta, Kennethe R. Boheler. Transitions in MHC Iso-mRNAs differ among rat strains and correlate with heart mass only in advanced age. J. Mol. Cell. Cardiol. 31(5): A20, 1999

32.    D. Tweedie, H-T Yang and K. R. Boheler. Temporal profile of ryanodine receptor gene expression and protein synthesis in mouse embryonic embryonic stem cell derived cardiac myocytes. Biophys. J. 78 (1, Part 2): 370A JAN 2000

33.   Huang-Tian Yang, Edward G. Lakatta and Kenneth R. Boheler. Site-directed excision and replacement of a ryanodine receptor 2 (RyR2) gene exon in embryonic stem cells and differentiation in vitro to cardiac myocytes. Circulation. 102 (18): II-141 (684), 2000

34.   Yi Zhu, Huang-Tian Yang and Kenneth R. Boheler. Identification of novel transcripts implicated in the progression to a senescent myocardium: results from microarrays. Circulation. 102 (18): II-142, 2000

35.    Huang-Tian Yang, David Tweedie, Su Wang, Antonio Guia, Tatiana Vinogradova, Konstantin Bogdanov, Paul D. Allen, Michael D. Stern, Edward G. Lakatta and Kenneth R. Boheler. Cardiac Ryanodine Receptor2 (RyR2) Regulates the Spontaneous Rate of Contraction of Cardiomyocytes Differentiated from Embryonic Stem Cells. Circualtion 104(17):II194, 2001

36.   Koban MU, Brugh SA, Riordon DR, Dellow KA, Yang HT, Tweedie D, Boheler KR.
A distant upstream region of the rat multipartite Na(+)-Ca(2+) exchanger NCX1 gene promoter is sufficient to confer cardiac-specific expression. Mech Dev. 109(2):267-79, 2001

37.  Huang-Tian Yang, David Tweedie, Su Wang, Antonio Guia, Tatiana Vinogradova, Konstantin Bogdanov, Paul D. Allen, Michael D. Stern, Edward G. Lakatta and Kenneth R. Boheler. The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development. Proc. Natl. Acad. Sci. USA. 99(14): 9225-9230, 2002

38.   杨黄恬　干细胞：科技领域的热点。科学54(3):12-14, 2002

39.   Boheler K.R, Czyz J., Tweedie D., Yang H-T, Anisimov S.V., Wobus A.W. Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ. Res. 91:189-201, 2002

40.   Wobus AM, Guan K, Yang HT, Boheler KR. Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation. Methods Mol. Biol. 185: 127-156, 2002

41.   杨黄恬，傅继东. 胚胎干细胞在体外向心肌细胞的分化：现状和展望。中国病理生理杂志 18(13):1667, 2002

42.   杨黄恬，Kenneth R. Boheler. 建立Ryanodine受体-2基因剔除的胚胎干细胞系并在体外分化成心肌细胞. 中国病理生理杂志 18(13):1784, 2002

43.     傅继东、 陈乐、 于会梅、王嵘、 杨黄恬. Ryanodin 受体2增快胚胎发育期心肌细胞胞浆内钙瞬变. 中国病理生理杂志 19(11): 1536, 2003

44.    陈乐、 傅继东、 杨黄恬. a1B肾上腺素受体参与间歇性低氧大鼠心肌保护机制. 中国病理生理杂志 19(11): 1532, 2003

45.    Yang Huang-Tian, Kenneth R. Boheler. In vitro Differentiation of Embryonic Stem (ES) cells to Cardioyocytes lacking the Sarcoplasmic Reticulum Ryanodine Receptor. Acta Pharmacol. Sin. 23(4):344-345, 2003

46.     Yan Xie,Yi Zhu, Wei-zhong Zhu, Le Chen, Zhao-Nian Zhou, Wen-Jun Yuan, Huang-Tian Yang. Contribution of phospholamban phosphorylation to the cardioprotection of intermittenthypoxia in ischemia-reperfused rat heart. Journal of the Hong Kong College of Cardiology 11(Suppl. 1): A10, 2003

47.    Ji-Dong Fu, Hui-Mei Yu, Rong Wang, Le Chen, Huang-Tian Yang. Changes of spontaneous Ca2+ transients during cardiomyocyte development: the role of type 2 ryanodine receptor. J Mol Cell Cardiol 37 (1): 224-225, 2004

48.   谢燕，朱卫中，朱仪，陈乐，周兆年，杨黄恬. 间歇性低氧适应对心肌严重钙超载损伤的作用. 中国病理生理杂志, 20(3): 2435, 2004

49.    谢燕，朱仪，朱卫中，陈乐，周兆年，杨黄恬. Phospholamban双位点磷酸化在间歇性低氧适应对抗心肌缺血再灌注损伤中的作用. 中国病理生理杂志, 20(3),: 2436, 2004

50.    Wei-Zhong Zhu, Jian-Wen Dong, Hai-Lei Ding, Huang-Tian Yang and Zhao-Nian Zhou. Postnatal development in intermittent hypoxia enhances resistance to myocardial ischemia/reperfusion in male rats. Eur. J. Appl. Physiol. 91(5-6):716-22, 2004

51.    Yan Xie, Wei-Zhong Zhu, Yi Zhu, Le Chen, Zhao-Nian Zhou, Huang-Tian Yang. Intermittent high altitude hypoxia protects the heart against lethal Ca2+ overload injury. Life Science. 76(5):559-72, 2004

52.   Hai-lei Ding, Hai-feng Zhu, Jian-wen Dong, Wei-zhong Zhu, Wei-wei Yang, Huang-tian Yang, Zhao-nian Zhou. Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury. Acta Pharmacol. Sin. 26(3):315-22, 2005

53.   Yan Xie, Yi Zhu, Wei-Zhong Zhu, Le Chen, Zhao-Nian Zhou, Wen-Jun Yuan and Huang-Tian Yang. Role of dual site phospholamban phosphorylation in intermittent hypoxia-induced cardioprotection against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 288:H2594-H2602, 2005

54.    Huang-Tian Yang, Yan Xie, Yi Zhu, Wei-Zhong Zhu, Le Chen, Zhao-Nian Zhou. Contribution of phospholamban phosphorylation to increased tolerance of the intermittent hypoxic heart to ischemic injury. FASAB J. 19(4):A707, 2005

55.   Huang-Tian Yang, Yan Xie, Yi Zhu, Wei-Zhong Zhu, Le Chen, Zhao-Nian Zhou. Contribution of phospholamban phosphorylation to increased tolerance of the intermittent hypoxic heart to ischemic injury. FASEB J. 19(4):A707, 2005

56.    Hong CHEN, Xing-jun WU, Xi-yuan LU, Liang ZHU, Li-ping WANG, Huang-tian YANG, Hong-Zhuan CHEN, Wenjun YUAN. Phosphorylated heat shock protein 27 is involved in enhanced heart tolerance to ischemia in short-term type 1 diabetic rats. Acta Pharmacologica Sinica 26(7):806-12. 2005

57.   Yang Huang-Tian. Cardioprotection of intermittent hypoxia adaptation: regulation of Ca²⁺ homeostasis.,CAPS News Communication生理通讯24(1²)： P14, 2005

58.    Fa-Bao Zhang; Li Li; Bo Fang; Ding-Liang Zhu; Huang-Tian Yang; Ping-Jin Gao Passage-restricted differentiation potential of mesenchymal stem cells into cardiomyocyte-like cells. Biochemical and Biophysical Research Communications.336: 784－792. 2005