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EDUCATION
1999.2-2001.2
Post-doctoral fellow
Department of Pharmacologe, Emory University
Atlanta, GA, USA
1992.12 --
1994.12
Post-doctoral fellow
Institute of Vascular Medicine, the Third Hospital, Beijing
Medical University, China
1989.1 --
1992.10
Ph.D. degree
Department of Cardiovascular Medicine, Xinjiang Medical
College, Urumqi, China and the Second Medicine, Nihon
University, Tokyo, Japan
1985.9 --
1988.9
Master degree of science
Department of Cardiovascular Medicine, Xinjiang Medical
College, Urumqi, China
1977.9 --
1982.9
Bachelor degree of medical science
Xinjiang Medical College, Urumqi, China
EMPLOYMENT
2001.8-present
Professor
Institute of Vascular Medicine, Peking University Third
Hospital, Beijing, China
1994.12 ¨C
2001.7
Associate Professor
Institute of Vascular Medicine, the Third Hospital, Beijing
Medical University,
Beijing, China
1988.9 --
1989.1
Attending physician
Department of Cardiovascular Medicine, the First Hospital,
Xinjiang Medical College,
Urumqi, China
1982.9 --
1985.9
Resident physician
Department of Internal Medicine, the First Hospital, Xinjiang
Medical College,
Urumqi, China
CURRENT ACADEMIC POSITIONS AND PROFESSIONAL SOCIETIES
Member, International
Society for Heart Research
Member, Chinese Society for Pharmacology
Member, Chinese Society for Pathophysiology
Vice chairman, Receptor Section, Chinese Society for Pathophysiology
Council member, Cardiovascular Section, Chinese Society
for Pharmacology
Editor of Molecular Cardiiology of China
SELECTED LIST OF PUBLICATIONS (55 of 86)
1£® Zhang
YY, Yu GS, Chen MZ, Han QD. Effect of alpha1-adrenoceptor
subtypes on beta-adrenoceptor mediated positive inotropic
response in rat left atria. Acta Physiologica Sinica 1994;
46:473
2£® Zhang
YY, Dong ED, Chen MZ, Han QD. Pathway for alpha1-adrenoceptor
and its subtypes to influence the beta-adrenoceptor mediated
positive inotropic response of heart in rats. Chin J Pharmacol
Toxicol 1995; 9:258
3£® Zhang
YY, Han QD, Tian B, et al. Altered effects of alpha1-adrenoceptor
on beta-adrenoceptor induced positive inotropic response
in the rat with cardiac insufficiency. Chin J Pathophysiol
1995; 11:567
4£® Han C
(Han QD), Yu GS, Zhang YY, Xu KM, et al. Alterations of
alpha1-adrenoceptor subtypes in the hearts of thyroxin-treated
rats. Eur J Pharmacol 1995; 294:593
5£® Wang LF,
Yu GS, Zhang YY, et al. Effects of long-term atenolol
treatment on beta-adrenoceptor subtypes in rat heart.
Acta Physiologica Sinica 1995;47:381
6£® Dong ED,
Han QD, Zhang YY, et al. Effect of PKC on vasctriction
mediated by alpha1-adrenoceptor tow subtypes. Chin Sci
Bull 1995; 40:837
7£® Xu KM,
Zhang YY, Qu P, et al. Alteration of cardiac alpha1-adrenergic
receptor subtypes in cardiac insufficient rat. Acta Physiologica
Sinica 1996; 48: 417
8£® Li YF,
Zhang YY, Lu ZZ, Han QD. Effects of long-term propranolol
treatment on number of alpha1-adrenoceptor subtypes in
rat heart. Chin J Pharmacol Toxicol 1996; 10:281
9£® Zhang
YY, Tian B, Chen SH, Han QD. Different susceptibilities
to desensitization of three alpha1-adrenoceptor subtypes
induced by sustained norepinephrine stimulation. Acta
Physiologica Sinica 1997; 49:1
10£® Zhang
YY, Xu KM, Han C. Alterations of Cardiac alpha1-adrenoceptor
subtypes in hypothyroidism rats. Clin Exp Pharmacol Physiol
1997; 24:481
11£® Zhang
YY, Lu Z, Wei H, Han C. Sertindole, a novel alpha1A-adrenoceptor
selective antagonist. Acta Pharmaceutica Sinica 1997;
32:496-501
12£® Zhang
P, Han QD, Zhang YY, et al. Alterations of cardiac and
lymphocyte beta-adrenoceptors in rat with chronic heart
failure. Sci Chin (C)1997;40:113
13£® Li YF,
Zhang YY, Lu ZZ, Han QD. Effects of long-term propranolol
treatment on beta-adrenoceptor response and subtypes in
rat hearts and lymphocytes. Chin J Pharmacol Toxicol 1997;
11:22
14£® Li YF,
Zhang YY, Yi YM, et al. The alterations of cardiac beta-adrenergic
receptor and subtypes in spontaneously hypertensive rats
of 48 weeks old. J Beijing Med Univ 1997; 29:97
15£® Zhu WZ,
Zhang YY, Han C. Characterization of subtype of alpha1-adrenoceptor
mediating vasoconstriction in perfused rat hindlimb. Eur
J Pharmacol 1997; 329:55-61
16£® Li YF,
Zhang YY, Yi YM, Han C. Alteration of cardiac beta-adrenoceptors
and subtypes with increasing age. Acta Physiologica Sinica
1997; 49:281-284
17£® Chen
H, Zhang YY, Han C. Chimeric dopamine D2/angiotensin AT1
receptors: role of the length of third intracellular loop
of D2 receptors in conferring specificity of receptor
binding and G-protein coupling. Acta Pharmacologica Sinica
1997;18:209-213
18£® Dong
E, Zhang YY, Tian B, Lu Z, Han C. Changes of subtypes
of ?1-drenoceptor in blood vessels of cardiac dysfunctional
rats. Chin Pathophysiol 1997; 13:232-235
19£® Lu Z,
Zhang YY, Han C. Comparison of functional alpha1-adrenoceptor
subtypes in aorta between 12 month- and 10 week-old rats.
Acta Physiologica Sinica 1997; 49:414-418
20£® Ipsen
M, Zhang YY, Dragsted N, Han C, Mulvany MJ. The antipsychotic
drug sertindole is a specific inhibitor of alpha1A-adrenoceptors
in rat mesenteric small arteries. Eur J Pharmacol 1997;
336:29-35
21£® Peng
M, Zhang YY, Lu Z, Xue Z, Han C. Analysis of alpha1-adrenoceptor
subtypes on the rat prostate. Chin J Pharmacol Toxicol
1997; 11:253-256
22£® Liang
T, Guan YY, He H, Han C, Zhang Y, Sun J. Comparison of
the Ca2+ movement by activation of alpha 1- adrenoceptor
subtypes in HEK239 cells. Life Sciences 1997;61:2127-2136
23£® Zhang
YY, Han C. Inverse agonist: a novel discovery in receptor
research (review). Progress of Physiology Sciences 1997;
28:9-13
24£® Zhang
YY, Han C. Cross-talk between alpha1- and beta-adrenoceptors
(review). Basic Medical Sciences and Clinics 1997; 17:241-244
25£® Han C,
Zhang YY. Alpha1-Adrenoceptor and its subtypes in prostate(review).
Basic Medical Sciences and Clinics 1997; 17:245-247
26£® Xu KM,
Lu ZZ, Wei H, Zhang YY, Han C. Alteration of ?1-adrenoceptor
subtypes in aortas of 12-month-old spontaneously hypertensive
rats. Eur J Pharmacol 1998;344: 31-36
27£® Xu KM,
Han C, Tian B, Zhang YY. Agonist-induced down-regulation
of ?1B-adrenoceptor in HEK 293 cells transfected with
?1B cDNA. Science in China (Series C) 1998;41:309-314
28£® Sun XG,
Zhang YY, Peng MQ, Lu ZZ, Han C. Alteration of ?1-adrenoceptor
and its subtypes in heart and aorta of insulin-resistant
hypertensive rats. Chin J Pathaphysiol 1998;14:113-117
29£® Gong
HB, Zhang YY, Han C. Alterations of functional ?1-adrenoceptor
and its subtypes in aorta from diabetic hypertensive rats.
J Beijing Med Univ 1998;30:289-292
30£® Zhang
YY, Yi YM, Li YF, Han C. Comparison of cardiac ?1-adrenoceptor
subtypes between 12-month-old and 3-month-old Wistar rats.
Chin J Pharmacol Toxicol 1998;12:101-104
31£® Yi YM,
Zhang YY, Li YF, Liu HX, Han C. Alterations of ?1-adrenoceptor
subtype subtypes in heart of 12 month-old spontaneously
hypertensive rats. Chin J Pathaphysiol 1998;14:226-229
32£® Lu ZZ,
Zhang YY, Liu HX, Han C. Alterations of ?1-adrenoceptor
subtypes in aorta of middle-aged spontaneously hypertensive
rats. Chin J Pathaphysiol 1998;14:337-341
33£® Li HW,
Geng QM, Zhang YY, Han C. Pathways of signal transduction
of intracellular Ca2+ increase mediated by three subtypes
of ?1-adrenoceptor in HEK293 cells. Acta Physiol Sinica
1998;50:349-354
34£® Zhu WZ,
Zhang YY, Han QD. Characterization of subtype of ?1-adrenoceptor
mediating vasconstrition in perfused SHR hindlimb. J Nantong
Med college 1997;17:436-439
35£® Yan M,
Zhang YY, Du XJ, Han C. Functional assessment of ?1-adrenoceptor
subtypes in porcine coronary artery. Clin Exp Pharmacol
Physiol 1998;25:682-685
36£® Zhu WZ,
Zhang YY, Han C. Characterization of subtype of ?1-adrenoceptor
mediating vasoconstriction in perfused rat mesenteric
vascular bed. Acta Pharmacol Sci 1999;20(2):151-156
37£® Wei Hong,
Lu Zhizhen, Zhang Youyi and Han Qide. Analysis of ?1-adrenoceptor
subtypes in neonatal rat heart. Chinese Science Bulletin,
1999, 44(12): 1098-1101
38£® Zhu Wei-zhong,
Gao Ben-bo, Li He-wang, Zhang You-yi, Han Qi-de. Tyrosine
Kinase participates in ?1A-Adrenoceptor-mediated increase
of intracellular calcium in human embryo kidney293 cells.
Acta Pharmacol Sin, 1999£¬20(11): 1025-1030
39£® Zhang
YY, Xu KM, Han C. ?1-Adrenoceptor subtypes mediating inotropic
responses in rat heart. J Pharmacol Exp Ther. 1999 Nov;291(2):829-36.
40£® Zhang
YY, Sun XG and Han QD. The distribution of three ¦Á1-adrenoceptor
subtypes in different components of rat heart. J Beijing
Med Univ 1999,31:103-105
41£® Li, Z.,
Y. Zhang, D. Li, and Y. Feng. Destabilization and mislocalization
of MBP mRNAs in quaking dysmyelination lacking the QKI
RNA-binding proteins. J. Neurosci. 20:4944-49534 (2000)
42£® Zhang
YY and Feng Y. Distinctive molecular mechanisms leads
to diminished myelin basic protein and 2,3-cyclic nucleotide
3-phosphodiesterase in qkv dysmyelination. J Neurochem.
2001£¬ 76£º1-9
43£® Li ZZ,
Zhang YY, Ku L, Wilkinson KD, Warren ST and Feng Y. The
fragile X mental retardation protein inhibits translation
via interacting with mRNA. Nucleic Acids Research. 2001;29:2276-2283
44£® Lei B,
Zhang Y and Han C. Sustained norepinephrine stimulation
induces different regulation of expression in three ¦Á1-adrenoceptor
subtypes. Life Sciences 2001;69:301-308
45£® GAO Ben-Bo,
LEI Bei-Lei, ZHANG You-Yi and HAN Qi-De. Cell proliferation
and Ca2+-calmodulin dependent protein kinase activation
mediated by ?1A- and ?1B-adrenergic receptor in HEK293
cells. Acta Pharmacol Sin, 2000, 21(1): 55-59
46£® Lei BL,
Zhang YY, Han QD. Changes of mRNA expression induced by
sustained norepiniphrine stimulation are different in
subtypes of ?1-adrenoceptor in HEK293 cells. Clinical
and Experimental Pharmacology and Physiology; 2002: 29(12):1084-90
47£® Zhang
Y, Lu Z, Ku L, Chen Y, Wang H, Feng Y*. Tyrosine phosphorylation
of QKI mediates developmental signals to regulate mRNA
metabolism. EMBO J. 2003 Apr 15;22(8):1801-10
48£® Zifan
Lu, Youyi Zhang, Li Ku, Houping Wang, Amir Ahmadian and
Yue Feng*. The quakingviable mutation affects qkI mRNA
expression specifically in myelin-producing cells of the
nervous system. Nucleic Acids Research, 2003;. 31 (15):4616¡À4624
49£® XU Qi,
ZHU Weizhong, L¨¹ Zhizhen, ZHANG Youyi* & HAN Qide
?1A-adrenergic receptor mediated pressor response to phenylephrine
in anesthetized rat. Science in China Ser. C Life Sciences
2003, 33£¨2£©:133-138
50£® SONG
Y, HUANG Y, HAN QD and ZHANG YY*. Characterization of
cAMP accumulation mediated by three ?1-adrenoceptor subtypes
in HEK293 cells. Acta Pharmacol Sin, 2003, 24(6):549-554
51£® HAN JL,
ZHANG YY, LU ZZ, MAO JM, CHEN MZ, HAN QD*. Functional
?1-Adrenergic Receptor Subtypes in Human Right Gastroepiploic
Artery. Acta Pharmacol Sin, 2003, 24 (4):327-331
52£® Feng
Yin, Ping Li, Ming Zheng, Li Chen, Qi Xu, Kai Chen, Yong-yu
Wang, You-yi Zhanag*, and Chide Han. Intereleukin-6 Family
of Cytokines Mediates Isoproterenol-Induced Delayed STAT3
Activation in Mouse Heart. The Journal of Biological Chemistry,
2003 23:21070-21075
53£® Li P,
Li J, Feng X, Li Z, Hou R, Han C, Zhang Y*. Gene expression
profile of cardiomyocytes in hypertrophic heart induced
by continuous norepinephrine infusion in the rats. Cell
Mol Life Sci. 2003;60(10):2200-9
54£® Jinliang
Li, Ping Li, Xinheng Feng, Zhaoping Li, Rong Hou, Chide
Han, Youyi Zhang*. Effects of losartan on pressure overload
induced cardiac gene expression in rats. CEPP 2003;30:827-832
55£® ZHANG
Yong-Zhen, ZHANG You-Yi, CHEN Ming-Zhe, HAN Chide*. ?-Adrenoceptors
potentiate ?1-adrenoceptor mediating inotropic response
in rat left atria. Acta Pharmacologica Sinica 2004; 25(1):
29-34
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