张翼

 

 张翼, , 19544月出生,河北安国县人。1975年毕业于内蒙古医学院医学系,1990年于新疆医科大学获医学硕士学位,2000年于中国科学院上海生理研究所获理学博士学位,20002002年于美国哈佛大学医学院作博士后研究,20022003年于美国加州大学戴维斯分校作博士后研究。现任河北医科大学生理学教研室主任、生理学教授、博士生导师,并担任中国生理学会理事,中国生理学会循环、呼吸、泌尿生理专业委员会委员,河北省生理科学会常务理事, 生理学报编委。

 多年来主要从事心血管生理学研究,包括心脏生理学、心肌细胞电生理及其离子通道、低氧心血管生理学及间歇性低氧心脏保护作用,也曾进行低氧诱导呼吸运动控制可塑性的电生理学研究。先后获多项国家自然科学基金、河北省自然科学基金资助,在国内外重要学术期刊发表文章40余篇,其中被SCI期刊收录24篇。

地址:石家庄市中山东路361号河北医科大学生理学教研室050017;

电话: 0311-86265643(办) 传真: 0311-86266811

电子邮件: zhangyhenry@yahoo.com

近年来发表的文章

1.        Zhang LP, Yin JX, Liu Z, Zhang Y, Wang QS, Zhao J. Effect of resveratrol on L-type calcium current in rat ventricular myoxytes. Acta Pharmacol Sin. 2006; 27(2);179-183.

2.        McGuire M, Zhang Y, White DP, Ling L. Phrenic long-term facilitation requires NMDA receptors in the phrenic motonucleus in rats. J. Physiol.(Lond.). 576(2): 599-611,2005.

3.        Zhang Y, Zhong N, Gia J, Zhou Z. Effects of chronic intermittent hypoxia on the hemodynamics of systemic circulation in rats. Jpn J Physiol. 2004 Apr; 54 (2):171-4.

4.        Zhang Y, McGuire M, White DP and Ling L. Serotonin receptor subtypes involved in vagus nerve stimulation-induced phrenic long-term facilitation in rats. Neurosci Lett. 2004 Jun 10; 363(2):108-11.

5.        McGuire M, Zhang Y, White DP and Ling L.  Serotonin Receptor Subtypes Required for Ventilatory Long-Term Facilitation and Its Enhancement after Chronic Intermittent Hypoxia in Awake Rats.   Am J Physiol Regul Integr Comp Physiol. 2004; 286(2):R334-41.

6.        Fang QZ, Zhong N, Zhang Y and Zhou ZN.  Tetrandrine inhibits Ca2+-activated chloride channel in cultured human umbilical vein endothelial cells. Acta Pharmacol Sin. 2004; 25(3):327-333.

7.        Zhang Y, McGuire M, White DP, and  Ling L.  Episodic Phrenic-Inhibitory Vagus Nerve Stimulation Paradoxically Induces Phrenic Long-Term Facilitation in Rats.  J Physiol.(Lond.) 2003; 551(3): 981-991.

8.        Xu YF,  Tuteja D, Zhang Z, Xu DY, Zhang Y, Rodriguez J, Nie LY, Tuxson HR, Young JN, Glatter KA, Vazquez AE, Yamoah EN, and Chiamvimonvat N.  Molecular identification and functional roles of a Ca2+-activated K+ channel in human and mouse hearts.  J. Biol. Chem. 2003; 278(49): 49085-49094.

9.        McGuire M, Zhang Y, White DP and Ling L.  Chronic Intermittent Hypoxia Enhances Ventilatory Long-Term Facilitation in Awake Rats.  J Appl Physiol.  2003; 95:1499-1580.

10.    McGuire M, Zhang Y, White DP and Ling L.  Effect of hypoxic episode number and severity on ventilatory long-term facilitation in awake rats   J. Appl. Physiol. 2002, 93(6): 2155-2161.

11.    Zhong N, Fang QZ, Zhang Y, Xia JS, Qian JQ, Zhou ZN. Inhibitory effects of DDPH on two components of delayed rectifier potassium current in guinea pig ventricular cells. Acta Pharmacol Sin. 2002; 23(7): 601-608.

12.    Zhong N, Zhang Y, Zhu HF, Wang JC, Fang QZ, Zhou ZN. Myocardial capillary angiogenesis and coronary flow in ischemia tolerance rat by adaptation to intermittent high altitude hypoxia. Acta Pharmacol Sin. 2002; 23(4): 305-310.

13.    Zhang XM, Yang S, Zhang Y, Zheng P, Jiang MH, Zhou ZN. Stimulation by melittin of Na+-Ca2+ exchange current in ventricular myocytes of guinea pigs. Acta Pharmacol Sin. 2001; 22(1): 10-14.

14.    Zhang Y, Zhong N, Zhou ZN.  Effects of intermittent hypoxia on action and contraction of rat papillary muscle. Life Sci. 2000; 67(20): 2465-2471.

15.    Zhuang JG, Zhang Y, Zhou ZN. Hypoxic preconditioning upregulates KATP channels through activation of PKC in rat ventricular myocytes.  Acta Pharmacol Sin. 2000; 21(9): 845-849.

16.    Tong QC , Zhang Y, Li DP, Zhou ZN, Ji YH. The blocking effect of BmP02, one novel short-chain scorpion peptide on transient outward K+ channel of adult rat ventricular myocyte. Regul Pept. 2000; 90(1-3): 85-92.

17.  Zhang Y, Zhong N, Zhou ZN.  Estradiol potentiation of antiarrhythmia and antioxidation in intermittent hypoxia rat.  Acta Pharmacol Sin. 2000; 21(7): 609-612.

18.    张翼,钟宁,周兆年. 间歇性低氧对大鼠心肌的抗心律失常与抗氧化效应. 中国生理学报 200052(2): 89-92.

19.    Zhong N, Zhang Y, Fang QZ, Zhou ZN. Intermittent hypoxia exposure-induced heat-shock protein 70 expression increases resistance of rat heart to ischemic injury. Acta Pharmacol Sin. 2000; 21(5): 467-472.

20.  Zhong N, Fang QZ, Zhang Y, Zhou ZN.  Volume- and calcium- activated chloride channels in human umbilical vein endothelial cells. Acta Pharmacol Sin. 2000; 21(3): 215-220.

21.    仰礼真, 张翼,李进嬉,朱依纯,张志雄,李燕,周兆年. 银杏苦內酯B对豚鼠心室肌细胞动作电位及L-型钙电流的影响. 中国药理学通讯. 2000; 16(2):195-198.

22.    Zhong N, Fang QZ, Zhang Y, Zhou ZN.  Inhibition of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenyl-ethylamino) propane hydrochloride on inward rectifier and delayed rectifier K+ currents in guinea pig ventricular myocytes.  Acta Pharmacol Sin. 2000; 21(4): 301-305.

23.    宋立林, 张翼, 谷双振, 卢慎圭, 周兆年  雌二醇对豚鼠心室肌细胞L型钙通道的抑制作用   中国应用生理学杂志  2000; 16(2):145-147.

24.    钟宁,张翼,朱海峰,周兆年 间歇性低氧处理预防缺血再灌注引起的mtDNA缺失和线粒体结构损伤 中国生理学报 2000; 52(5): 375-380.

25.     Xia JS,Guo DL, Zhang Y, Zhou ZN, Zeng FD, Hu CJ. Inhibitory effects of dauricine on potassium currents in guinea pig ventricular myocytes. Acta Pharmacol Sin. 2000; 21(1): 60-64.