周士胜

    周士胜:博士,大连大学医学院生理学教授,医学研究中心主任。1980年毕业于新乡医学院,19897于第四军医大学获硕士学位后留校任教,19967月在第四军医大学获生理学专业博士学位。历任第四军医大学生理学教研室助教、讲师、副教授、教授、博士研究生导师之职,曾任第四军医大学生理学教研室主任以及军队生理与病理生理学会专业委员会副主任委员。2004年转业后被特聘到大连大学医学院工作。现为中国生理学会循环、呼吸、肾脏生理专业委员会委员,辽宁省生理学会理事,大连市医学会生理学分会副主任委员,《生理学报》和《世界华人消化杂志》编委。主要研究领域为(1)离子通道与重大疾病的关系;(2)心血管生理学;(3)细胞生理学。曾赴美国西南医学中心、日本国立生理学研究所和香港大学医学院进行学术交流和科研合作。1997年曾受日本国立生理学研究所所长的特邀,以客座教授身份到日本国立生理学研究所进行客座研究。1999年和2000年先后两次受到日本学术振兴会(JST)战略基础研究(CREST)推进部部长的邀请,参与日本国家CREST项目《细胞容积调节的分子机制及其生理作用》的研究。近年来在氯通道研究方面取得了一定成绩,首次提出了心肌离子通道可能调控阳离子通道的假说;首次用RNA干涉技术研究了胃癌细胞氯通道的特点。迄今为止已主持国家自然科学基金资助项目4项、国家教委留学回国人员基金、军队杰出中青年人才基金和长江学者匹配骨干教师基金各1项。在国内外专业杂志包括《Circulation Research》、《Proc Natl Acad Sci USA》、《American Journal of Physiology》、《Journal of Applied Physiology》、《Pflugers Arch: European Journal of Physiology》等上已发表论文60余篇。

PUBLICATIONS

1.     Zhou SS, Yang J, Li YQ, Zhao LY, Xu M, Ding YF. Effect of Cl- channel blockers on aconitine-induced arrhythmias in rat heart. Exp Physiol. 90:865-872, 2005.

2.    Lai XG, Yang J, Zhou SS, Zhu J, Li GR, Wong TM. Involvement of anion channel(s) in the modulation of the transient outward K+ channel in rat ventricular myocytes. Am J Physiol Cell Physiol. 287:C163-170, 2004.

3.      Zhou SS, Gao Z, Dong L, Ding YF, Zhang XD, Wang YM, Pei JM, Gao F, Ma XL.. Anion channel influence excitation-contraction coupling by modulating L-type Ca2+ channel in ventricular myocytes. J Appl Physiol 93:1660-1668, 2002.

4.      Zhou SS, Takai A, Okada Y. Regulation of Cardiac CFTR Cl Channel Activity By a Mg2+-Dependent Protein Phosphatase. Pflugers Arch-Eur J Physiol 444:327-334, 2002.

5.        Liou HH, Zhou SS, Huang CL. Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. Proc Natl Acad Sci USA 96:5820-5825, 1999.

6.        Zhou SS, Hazama A, and Okada Y. Tyrosine kinase-independent extracellular action of genistein on the CFTR Cl channel. Jpn J Physiol 48:389-396, 1998.

7.     Zhou SS, Takai A, Tominaga M, Okada Y. Phosphatase-mediated enhancement of cardiac cAMP-activated Cl- conductance by a Cl- channel blocker, anthracene-9-carboxylate. Circ Res 81:219-228, 1997.

8.     Zhou SS. Roles of cytoskeleton in the regulation of ion channels. Progress in Physiological Sciences 36:172-175, 2005.

9.     Zhang Y, Jia LT, Li QX, Wang CJ, Zhou SS, Yang AG. Vector construction and silencing effect of volume-regulated chloride channel gene-targeted small interfering RNA. J Fourth Mil Med Univ 26:769-772, 2005.

10.  Jia B, Li ZC, Zhang LL, Dong MQ, Wang YM, Zhou SS. Effects of atrial natriuretic peptide on relaxation and constriction of aorta and pulmonary artery in endotoxemia rat. Chin J Appl Physiol 20:136-140, 2004.

11.    Tian J, Sha JH, Zhou SS, Chen YM. Progress of investigation on volume-regluated anion channels. Progress in Physiological Sciences 35(3):255-258, 2004.

12.    Chen YM, Yang J, Hu YZ, Tian J, Zhou SS. Role of volume-regulated chloride channel in proliferation of human gastric carcinoma cell line SGC7901. J Fourth Mil Med Univ 25(6):489-903, 2004. (in Chinese)

13.    Tian J, Tao L, Cao YX , Dong L, Hu YZ, Yang AG, Zhou SS.  Effects of niflumic acid on the proliferation of human hepatoma cells. Acta Physiologica Sinica  55:160-164, 2003.

14.    Ma H, Pei JM, Wang YM, Yang AG, Zhou SS. Effects of anions and anionchannel blockers on vascular tone in rat aorta. Chin J Appl Physiol 19(2):105-108, 2003.

15.    Ma JJ, Zhou SS, Bao TY, Ju SC, Hu YZ, Yang AG. Inhibitory effects of NPPB on human renal carcinoma cell line GRC-1. J Fourth Mil Med Univ 24(9):822-824, 2003.

16.    Zhang XD, Zang YM, Zhou SS, Zang WJ, Yu XJ, Wang YM. Effect of extracellular chloride concentration on deactivation kinetics of rat ClC-1 chloride channel. Acta Physiologica Sinica 54:196-200, 2002. 

17.    Zhang XD, Zang YM, Zhou SS. The biology and related disease of voltage-gated chloride channel (CIC chloride channel). Progress in Physiological Sciences 32:327-330, 2001.

18.    Gao Z, Zhu MZ, Zhou SS, et al. Effects of genistein on the proliferation of cardiac fibroblasts. Chinese Journal of Pharmacology and Toxicology 15:159-160, 2001.

19.    Zhang QH, Hu YZ, Zhou SS, Wang FZ. Inhibitory effects of genistein on the proliferation of the anterior pituitary cells of rats. Acta Physiologica Sinica 53:51-54, 2001.

20.    Zhou SS, Zang YM. Effects of anthracene-9-carboxylic acid on cardiac ventricular action potential duration and L-type Ca2+ channel in guinea pig. Chinese Journal Applied Physiology 16:1-4, 2000.

21.    Lu SY, Zhu MZ, Zhou SS, Yu J. Study on c-fos expression induced by anthracene-9-carboxylic acid in cultured cardiomyocytes and intracellular factors involved in its regulation. Chinese Journal of Histochemistry and Cytochemistry 9:280-283, 2000.