Shi-Sheng ZHOU

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NAME: Shi-Sheng ZHOU (M.D., Ph.D.)

 

ADDRESS

Institute of Basic Medical Sciences & Department of Physiology, Medical College , Dalian University .

           Dalian Economic Technological Development Zone, Dalian 116622,

           Liaoning , China

Tel: 86-411-87402740

Fax: 86-411-87402053

e-mail: zhouss@dlu.eud.cn

 

EDUCATION

8.1993~7.1996 Postgraduate Student, Doctor Degree in Medicine

Specialty: Cardiovascular Physiology

Department of Physiology, The Fourth Military Medical University , Xi'an , Shaanxi 710032, China

8.1986~7.1989 Postgraduate Student, Master Degree in Medicine

Specialty: Cardiovascular Physiology

Department of Physiology, The Fourth Military Medical University , Xi'an , Shaanxi 710032, China

3.1977~3.1981 Undergraduate Student of Medicine

Xinxiang Medical College , Xinxiang , Henan , China

 

PROFESSIONAL EXPERIENCE

10.2004~present: Professor, Institute of Basic Medical Sciences , Medical College , Dalian University . Dalian Economic Technological Development Zone, Dalian 116622, Liaoning , China

10.2001~9.2004: Professor, Director of Department of Physiology, The Fourth Military Medical University , Xi'an , Shaanxi 710032, China

10.1999~9.2001: Associated Professor, Director of Department of Physiology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China

8.1996~10.1999: Associated Professor, Vice-Director, Department of Physiology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China

6.2002~9.2002: Visiting professor, Department of Physiology, Medical College, University of Hong Kong, Hong Kong, China

4.2000~5.2000: Visiting Scientist, Department of Cellular and Molecular Physiology, National Institute for Physiological Sciences, Okazaki 444, Japan

1.1999~6.1999: Visiting Scientist, Department of Cellular and Molecular Physiology, National Institute for Physiological Sciences, Okazaki 444, Japan

6.1998~12.1998: Visiting Scholar, U.T. Southwestern Medical Center at Dallas, Department of Internal Medicine, H5-126, 5323 Harry Hines Blvd, Dallas, TX 75235, USA

11.1997~12.1997 Visiting Professor, Department of Cellular and Molecular Physiology, National Institute for Physiological Sciences, Okazaki 444, Japan

6.1997~9.1997 Visiting Professor, National Institute for Physiological Sciences, Okazaki 444, Japan

3.1995~4.1996 Visiting Scientist, Department of Cellular and Molecular Physiology, National Institute for Physiological Sciences, Okazaki 444, Japan

12.1990~7.1996 Lecturer, Department of Physiology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China

4.1981~7.1986 Research Assistant, Department of Physiology, Xinxiang Medical College, Xinxiang, Henan, P.R. China

 

RESEARCH AREAS

Major in Cardiovascular Physiology; Cellular and Molecular Physiology; Channelopathy.

 

GRANTS:

1. National Natural Science Foundation of China , No. 30570665 (2006-2008)

2. National Natural Science Foundation of China , No. 30270602 (2003-2005)

3. National Natural Science Foundation of China , No. 39870318 (1999-2001)

4. National Natural Science Foundation of China , No. 39770281 (1998-2000)

5. Foundation for University Key Teachers by the Ministry of Education of China (2001-2002)

6. Fund for Distinguished Young Scholars of the PLA (2001-2003).

7. Initial Fund from Chinese Education Minister (1998)

 

PUBLICATIONS

1.     Zhou SS, Yang J, Li YQ, Zhao LY, Xu M, Ding YF. Effect of Cl- channel blockers on aconitine-induced arrhythmias in rat heart. Exp Physiol. 90:865-872, 2005.

2.    Lai XG, Yang J, Zhou SS, Zhu J, Li GR, Wong TM. Involvement of anion channel(s) in the modulation of the transient outward K+ channel in rat ventricular myocytes. Am J Physiol Cell Physiol. 287:C163-170, 2004.

3.      Zhou SS, Gao Z, Dong L, Ding YF, Zhang XD, Wang YM, Pei JM, Gao F, Ma XL.. Anion channel influence excitation-contraction coupling by modulating L-type Ca2+ channel in ventricular myocytes. J Appl Physiol 93:1660-1668, 2002.

4.      Zhou SS, Takai A, Okada Y. Regulation of Cardiac CFTR Cl¨C Channel Activity By a Mg2+-Dependent Protein Phosphatase. Pflugers Arch-Eur J Physiol 444:327-334, 2002.

5.        Liou HH, Zhou SS, Huang CL. Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. Proc Natl Acad Sci USA 96:5820-5825, 1999.

6.        Zhou SS, Hazama A, and Okada Y. Tyrosine kinase-independent extracellular action of genistein on the CFTR Cl¨C channel. Jpn J Physiol 48:389-396, 1998.

7.     Zhou SS, Takai A, Tominaga M, Okada Y. Phosphatase-mediated enhancement of cardiac cAMP-activated Cl- conductance by a Cl- channel blocker, anthracene-9-carboxylate. Circ Res 81:219-228, 1997.

8.     Zhou SS. Roles of cytoskeleton in the regulation of ion channels. Progress in Physiological Sciences 36:172-175, 2005.

9.     Zhang Y, Jia LT, Li QX, Wang CJ, Zhou SS, Yang AG. Vector construction and silencing effect of volume-regulated chloride channel gene-targeted small interfering RNA. J Fourth Mil Med Univ 26:769-772, 2005.

10.  Jia B, Li ZC, Zhang LL, Dong MQ, Wang YM, Zhou SS. Effects of atrial natriuretic peptide on relaxation and constriction of aorta and pulmonary artery in endotoxemia rat. Chin J Appl Physiol 20:136-140, 2004.

11.    Tian J, Sha JH, Zhou SS, Chen YM. Progress of investigation on volume-regluated anion channels. Progress in Physiological Sciences 35(3):255-258, 2004.

12.    Chen YM, Yang J, Hu YZ, Tian J, Zhou SS. Role of volume-regulated chloride channel in proliferation of human gastric carcinoma cell line SGC7901. J Fourth Mil Med Univ 25(6):489-903, 2004. (in Chinese)

13.    Tian J, Tao L, Cao YX , Dong L, Hu YZ, Yang AG, Zhou SS.  Effects of niflumic acid on the proliferation of human hepatoma cells. Acta Physiologica Sinica  55:160-164, 2003.

14.    Ma H, Pei JM, Wang YM, Yang AG, Zhou SS. Effects of anions and anionchannel blockers on vascular tone in rat aorta. Chin J Appl Physiol 19(2):105-108, 2003.

15.    Ma JJ, Zhou SS, Bao TY, Ju SC, Hu YZ, Yang AG. Inhibitory effects of NPPB on human renal carcinoma cell line GRC-1. J Fourth Mil Med Univ 24(9):822-824, 2003.

16.    Zhang XD, Zang YM, Zhou SS, Zang WJ, Yu XJ, Wang YM. Effect of extracellular chloride concentration on deactivation kinetics of rat ClC-1 chloride channel. Acta Physiologica Sinica 54:196-200, 2002. 

17.    Zhang XD, Zang YM, Zhou SS. The biology and related disease of voltage-gated chloride channel (CIC chloride channel). Progress in Physiological Sciences 32:327-330, 2001.

18.    Gao Z, Zhu MZ, Zhou SS, et al. Effects of genistein on the proliferation of cardiac fibroblasts. Chinese Journal of Pharmacology and Toxicology 15:159-160, 2001.

19.    Zhang QH, Hu YZ, Zhou SS, Wang FZ. Inhibitory effects of genistein on the proliferation of the anterior pituitary cells of rats. Acta Physiologica Sinica 53:51-54, 2001.

20.    Zhou SS, Zang YM. Effects of anthracene-9-carboxylic acid on cardiac ventricular action potential duration and L-type Ca2+ channel in guinea pig. Chinese Journal Applied Physiology 16:1-4, 2000.

21.    Lu SY, Zhu MZ, Zhou SS, Yu J. Study on c-fos expression induced by anthracene-9-carboxylic acid in cultured cardiomyocytes and intracellular factors involved in its regulation. Chinese Journal of Histochemistry and Cytochemistry 9:280-283, 2000.