Zhuan Zhou

Zhuan Zhou, 1984, B.S. Electronic instrumentation, Tongji University , Shanghai .  1990, Ph.D. (Prof. Huaguang Kang's lab) Biomedical Engineering, Huazhong University of Science and Technology (HUST), Wuhan .  Nov. 1990-Feb. 1993, postdoctoral fellow (Dr. Erwin Neher's lab), Max-Planck-Institute for Biophysical Chemistry, Goettingen , Germany .  Feb. 1993 - Oct. 1995, Research Instructor (Dr. Stanley Misler's lab), Departments of Physiology, Washington University . St. Louis , USA . Nov. 1995-97, Researcher Assistant Professor, Department of Physiology, Loyola University, Chicago, USA.  Sep. 1997-99, professor and head, Department of Neuroscience and Biophysics, University of Science and Technology of China , Hefei .  Apr. 1993-2000, professor and director, Nov. 1999-2004, Principle Investigator, Institute of Neuroscience , Chinese Academy of Sciences.  Consul of Biophysical Society of China , Chair of Neurobiophysics Committee (2002-2006). Consul of Chinese Association of Physiological Society (2002-2006). He is now a Senior Investigator and PI of the Celluar of Biophysics Laboratory at IMM, PKU.

 

SCI paper

1.   Lie-Cheng Wang, Wei Xiong, Jing Zheng, Yang Zhou, Hui Zheng, Chen Zhang, Liang-Hong Zheng, Xue-Liang Zhu, Zhi-Qi Xiong, He-Ping Cheng, Lu-Yang Wang and Zhuan Zhou* (2006) The timing of endocytosis following activation of a G-protein-coupled receptor in a sensory neuron. Biophysical Journal, (in press)

2.   Chen XK, Wang LC, Zhou Y, Zheng LH and Zhou Z* (2005) Kiss-and-Run” glutamate secretion in culture and freshly isolated rat hippocampal astrocytes. J. Neurosci., 25(40):9236 –9243.

3.   Xiao-Ke Chen, Lie-Cheng Wang, Yang Zhou, Qian Cai, Murali Prakriya, Kai-Lai Duan, Zu-Hang Sheng, Christopher Lingle and Zhuan Zhou* (2005) Endogenous activation of GPCRs modulates quantal size in chromaffin cells: roles of Gbg and PKC. Nature Neuroscience, 8(9):1160 - 1168.

4.   Kunfu Ouyang, Hui Zheng, Xiaomei Qin, Chen Zhang, Dongmei Yang, Xian Wang, Caihong Wu, Zhuan Zhou*, Heping Cheng* 2005Ca2+ Sparks and Secretion in Dorsal Root Ganglion Neurons. Proc Natl Acad Sci U S A., 102:12259-64.

5.   Bei Wu, Ye-Ming Wang, Wei Xiong, Liang-Hong Zheng, Chong-Luo Fu, Iain C. Bruce, Chen Zhang* and Zhuan Zhou* (2005) Optimization of a multi-channel puffer system for rapid delivery of solutions during patch-clamp experiments. Frontiers in Bioscience. 10:761-7

6.   Hua Yang, Chen Zhang, Hui Zheng, Wei Xiong, Zhuan Zhou, Tao Xu, Jiu Ping Ding (2005) A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons. Eur. Biophy. J., 34:1007-16

7.   Jing Yao, Xiang Chen, Yang Zhou, Li-Jun Yao, Xiao-Ke Chen, Nai-Xia Zhang, Zhuan Zhou, Tao Xu, Hou-Ming Wu, Jiu-Ping Ding (2005) BmP09, a ‘Long-Chain’ Scorpion Peptide Blocker of BK Channels. J. Biol. Chem. 280(15):14819-28

8.  Xiao RP, Cheng HP, Zhou Z, Chen YQ, Wu CH & Gu XC (2004) Can China Join in main stream of Molecular Medicine? Nature, 432: A44-47

9.  Xu CQ, He LL, Brone B, Martin-Eauclaire MF, Van Kerkhove E, Zhou Z, Chi CW. (2004) A novel scorpion toxin blocking small conductance Ca2+ activated K+ channel. Toxicon. 43, 961-71.

10.Chen Zhang, Wei Xiong, Hui Zheng, Liecheng Wang, Bai Lu and Zhuan Zhou* (2004) Calcium- and dynamin-independent endocytosis in dorsal root ganglion neurons. Neuron, 42: 225–236

11.Yu X, Duan KL, Shang CF, Yu HG and Zhou Z* (2004) Calcium influx through hyperpolarization-activated cation channels (Ih channels) contributes to activity-evoked neuronal secretion. Proc Natl Acad Sci U S A., 101:1051-1056.

12.Duan KL, Yu X, Zhang C, and Zhou Z* (2003) Control of Secretion by Temporal Patterns of Action Potentials in Adrenal Chromaffin Cells. J. Neurosci., 23(35):11235-43

13.Xuelin Lou, Xiao Yu, Xiao-Ke Chen, Liming He, Kai-Lai Duan, Anlian Qu, Tao Xu and Zhuan Zhou* (2003) Na channel inactivation: a comparison study between pancreatic islet ß-cells and adrenal chromaffin cells in rat. J. Physiol (Lond) 548: 191-202.

14.Chong-Xu Fan, Xiao-Ke Chen, Chen Zhang, Li-Xiu Wang, Kai-Lai Duan, Lin-Lin He, Ying Cao1, Shang-Yi Liu, Ming-Nai Zhong, Chris Ulens, Jan Tytgat, Ji-Sheng Chen*, Cheng-Wu Chi* and Zhuan Zhou*. (2003) A Novel Conotoxin from Conus betulinus, k-BtX, unique in Cysteine Pattern and in Function as a specific BK Channel Modulator. J. Biol. Chem. 278:12624-33

15.Lan Bao, Shan-Xue Jin, Chen Zhang*, Li-Hua Wang, Zhen-Zhong Xu,Fang-Xiong Zhang, Lie-Chen Wang, Feng-Shou Ning, Hai-Jiang Cai, Ji-Song Guan, Hua-Sheng Xiao, Zhi-Qing D. Xu, Cheng He, Tomas Hokfelt, Zhuan Zhou* and Xu Zhang* (2003) Activation of delta-Opioid Receptors on Dorsal Root Ganglion Neurons Induces Receptor Insertion and Neuropeptide Secretion. Neuron, 37:121-133.

16.Yong-Hua Ji, Jian-Guo Ye, Wei-Xi Wang, Lin-Lin He, Ya-Jun Li, Yan-Ping Yan, Chen Li, Zhi-Yong Tan, Zhuan Zhou. (2003) BmTX3, a Novel Specific Blocker of Ca2+-Activated K+ Channel from Asian Scorpion Venom: Purification, Genomic Organization and Function Assessment. J. Neurochem. 84(2):325-35.

17.Ping Song, Lie-Cheng Wang, Guo-Du Wang, Zhuan ZHou and Zhi-Qi Zhao. (2003) Interleukin-2 regulates calcium current and intracellular calcium via Mu opioid receptors in rat dorsal root ganglion neurons. Neuropharmacology, 43(8):1324-1329

18.He LM, Chen LY, Lou XL, Qu AL, Zhou Z, Xu T. (2003) Rapid inhibitory effects of corticosterone on calcium influx rat dorsal root ganglion neurons. Neuroscience, 116(2):325-33.

19.Zhou Z* & Bers.DM (2002) Time Course of Mitochondrial Antagonists Blockade in Intact Cells. European Journal of Physiology, 445:132-138

20.Wu JJ, He LL, Zhou Z, and Chi ZW (2002) Gene Expression, Mutation and Structure-Function Relationship of Scorpion Toxin BmP05 Active on SKCa Channels. Biochemistry, 41(8):2844-9

21.Zhang C & Zhou Z* (2002) Ca2+-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. Nature Neuroscience, 5(5):425-30 

22.He L, Chen L, Lou X, Qu A, Zhou Z, Xu T. (2002) Evaluation of beta-amyloid peptide 25-35 on calcium homeostasis in cultured rat dorsal root ganglion neurons. Brain Res 939(1-2):65-75

23.Lou XL, Zeng, XH, Qu AL and Zhou Z* (2001) Glucose induced Ca signals in rat pancreatic b cells. Progress in Natural Sciences, 11:109-114

24.Zhou.Z & Bers.DM (2000) Ca influx via L-type Ca channel at voltages positive to the reversal potential in ventricular myocytes. Journal of Physiology ( London ) 523: 57-66

25.Zeng XH, Qu AL, Lou XL, Xu JH, Wang JJ, Wu HX and Zhou Z* (2000) Ca signals induced from calcieum stores in pancreatic islets b-cells. Chinese Science Bulletin, 45:51-56

26.Zhou.Z*, Matlib.MA & Bers.DM* (1998) Cytosolic and mitochondrial Ca2+ signals in patch clamped mammalian ventricular myocytes. Journal of Physiology (London), 507379-403

27.Matlib, Z. Zhou, S. Knight, S. Ahmed, K. Choi, J. Krause-Bauer, R. Phillips, R.Altschuld, Y. Katsube, N. Sperelakis, D. Bers (1998) Oxo-Bridged Dinuclear ruthenium Ammine Complex Specifically inhibits Ca2+ Uptake into mitochendria in vitro and in situ in single cardinac myocytes. J. Biol. Chem.273(17):10223-31,

28.A.Elhamdani ,Z.Zhou & CR.Arttalejo (1998) Timing of dense-core vesicle exocytosis depends on the facilitation L-type Ca channel in adrenal chromaffin cells. J. Neurosci. 18(16):6230-40

29.Wei Shun-hui, Anlian Qu, Hongxiu Wu, Zhuan Zhou (1998). A kinetic model of control on secretion in neuroendocrine cells. IEEE/EMBS, 20: 3083-3086

30.Zhou.Z*, Misler.S & Chow .RH (1996) Rapid fluctuations in transmitter release from single vesicles in bovine adrenal chromaffin cells. Biophysical Journal, 70:1543-52

31.Zhou.Z*, Misler.S (1996) Amperometric detection of quantal secretion from patch-clamped rat pancreatic beta-cells. J Biol Chem 271(1):270-7

32.Zhou.Z*, Misler.S (1995) Amperometric detection of stimulus-induced quantal release of catecholamines from cultured superior cervical ganglion neurons. Proc Natl Acad Sci USA 92(15):6938-42

33.Burnashev, N., Zhou, Z., Neher, E. & Sakmann, B. (1995) Calcium flux and fractional calcium currents through recombinant GluR channels of NMDA-R, AMPA-R and KA-R Subtypes. J. Physiol. ( London ), 485:403-418

34.Zhuan Zhou & Stanley Misler (1995) Action potential induced catecholamine secretion in rat chromaffin cells. Journal of Biological Chemistry, 270: 3498-3505.

35.Zhuan Zhou* & Erwin Neher* (1993). Mobile and immobile Ca buffers in bovine adrenal chromaffin cells. J. Physiol. ( London ). 469: 245-273

36.Schneggenburger,R., Zhou,Z., Konnerth,A. & Neher,E. (1993). Fractional contribution of calcium to the cation current through glutamate receptors. Neuron, 11: 133-143

37.Zhuan Zhou & Erwin Neher (1993). Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells. Pflugers Arch, 425: 511-517.

38.Zhuan Zhou* & Huaguang Kang (1990) patch clamp noise from  seal impedance and the pipette capacitance. Proc. IEEE/EMBS, 12(4):1679-1680.

39.H.G. Kang & Zhuan Zhou (1990) Low noise design of patch clamp amplifier, Proc. IEEE/EMBS, 12(3):1103-1104.