ISSN 0371-0874, CN 31-1352/Q

最新录用

肺衰老在慢性呼吸系统疾病中的研究进展

周凯1,陈龙2,秦晓群1,向阳1,瞿湘萍1,刘惠君1,刘持1*

中南大学基础医学院生理学系1,长沙 410078;新疆医科大学基础医学院机能实验中心2,乌鲁木齐 830017

摘要

细胞衰老是一个极其复杂的过程,其特征表现为线粒体结构功能障碍、端粒缩短、炎症微环境、蛋白稳态失衡、表观遗传改变、DNA损伤修复异常等进而导致组织器官的结构功能损伤诱发衰老相关疾病发生发展。衰老包括龄引起生理性衰老,还包括多种因素所诱病理性衰老。值得注意的是,肺作为与外界空气直接接触的靶器官易于多种刺激而出现病理性早衰,即肺衰。研究发现在大多数慢性呼吸系统疾病的肺内都存在一定比例衰老细胞,但是这些衰老细胞诱导肺衰老及其在慢性呼吸系统疾病中的内在机制仍很不清楚。本文重点描述了肺衰老的诱因和分类,肺衰老参与慢性呼吸系统疾病的内在机制及抗衰老治疗在慢性呼吸系统疾病的应用有望为临床上慢性呼吸系统疾病的防治提供新的研究思路和理论依据

关键字: 细胞衰老;慢性呼吸系统疾病;SASP;Senolytic药物;CAR-T细胞疗法;

分类号:R332

Research Progress of Lung Aging in Chronic Respiratory Diseases

ZHOU Kai1, CHEN Long2, QIN Xiao-Qun1, XIANG Yang1, QU Xiang-Ping1, LIU Hui-Jun1, LIU Chi1*

1Department of Physiology, School of Basic Medical Science, Central South University, Changsha 410078,China 2Functional Experiment Center, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830017, China

Abstract

Cell aging is an extremely complex process, which is characterized by mitochondrial structural dysfunction, telomere shortening, inflammatory microenvironment, protein homeostasis imbalance, epigenetic changes, abnormal DNA damage and repair, etc. Aging is usually accompanied by structural and functional damage of tissues and organs which further its underlying mechanism in chronic respiratory diseases and the underlying mechanism is still obscure. This paper focuses on the causes and classification of lung aging, the internal mechanism of lung aging involved in chronic respiratory diseases, and the application of anti-aging treatments in chronic respiratory diseases. We expect to provide new research ideas and theoretical basis for the clinical prevention and treatment in chronic respiratory diseases.

Key words: Cell senescence; Chronic respiratory disease; Senescence-Associated Secretory Phenotype (SASP); Senolytic drugs; Chimeric antigen receptor (CAR)-T cell therapy;

收稿日期:2021-05-27  录用日期:2021-07-12