The mechanism on hyperpolarization of membrane potential induced by adenosine in frog melanotrophs
It has been previously shown that the activation of A_(1) adenosine receptors in frogmelanotroph induced a hyperpolarization accompanied by blockage of spontaneous action potentials. In the present report, we explored mechanisms underlying the above phenomenon using the pacth-clamp technique in whole-cell and cell-attached configuration. The result showed that adenosine could increase the opening of non-voltage-activated potassium channels leading to hyperpolarization, but an inward cation current activated by hyperpolarizing pulse was not involved.
. 腺苷引起促黑素细胞膜电位超极化的离子机制[J]. 生理学报 1998; 50 (5): .
. The mechanism on hyperpolarization of membrane potential induced by adenosine in frog melanotrophs. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).