ISSN 0371-0874, CN 31-1352/Q



马秀英, 范振中, 何瑞荣

河北医科大学基础医学研究所生理室. 河北, 石家庄 050017



关键词: 腺苷; 腺苷受体; 心交感传入纤维; 延髓腹外侧头端区

Effects of intraventricular and epicardial application of adenosine on electrical activity of medullary pgl neurons

Ma Xiuying, Fan Zhenzhong, He Ruirong

Department of Physiology, Institute of Basic Medicine, Hebei Medical University. Shijiazhuang 050017, Hebei, China


The effects of intraventricular injection and epicardial application of adenosine on spontaneous electrical activity of nucleus paragigantocellularis lateralis (PGL) neurons in rostral ventrolateral medulla(RVLM) were examined in 35 anesthetized rats with sinoaortic denervation and vagotomy. The results obtained were as follows: (1) The sPOntaneous discharge of 121 PGL neurons (mean discharge rate: 22.5+-1.9 spikes/s) were recorded in 35 rats. (2) In resp0nse to intraventricular injection of adenosine (0.5 #mu#mol/kg), mean arterial pressure (MAP) was initially increased by 1.7+-0.2 kPa(P<0.001) and subsequently decreased by 4.6+-0.5 kPa(P<0.001), while the heart rate (HR) was decreased by 126.5+-12.3 bpm (P<0.001). Of 35 PGL spontaneous discharge units responsive to intraventricu1ar injection of adenosine, 30 showed an average increase from 21.9+-2.6 to 29.2+-3.4 spikes/s (P<0.001), 3 with no change, while 2 with a decrease.

Key words: Adenosine;Adenosine receptors;Cardiac sympathetic afferents;Rostral ventrolateral medulla

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马秀英, 范振中, 何瑞荣. 心室内和心外膜应用腺苷对延髓PGL神经元电活动的影响 [J]. 生理学报 1997; 49 (5): .

Ma Xiuying, Fan Zhenzhong, He Ruirong. Effects of intraventricular and epicardial application of adenosine on electrical activity of medullary pgl neurons. Acta Physiol Sin 1997; 49 (5): (in Chinese with English abstract).