张志方, 王竹立, 卢光启
中山医科大学生理教研室. 广东, 广州 510089
关键词： 组胺; 第三脑室; 生长抑素拮抗剂; 胃酸分泌; 硫酸阿托品
Centrally administrated histamine on gastric acid secertion
Zhang Zhifang, Wang Zhuli, Lu Guangqi
Department of Physiology, Sun Yat-Sen University of Medical Sciences. Guangzhou 510089, Guangdong, China
The present experiment is undertaken to study the peripheral mechanism of the inhibitory effect of intra third ventricular administration of histamine (HA, icv) on gastric acid secretion. Gastric acid was continuously washed with 37℃ saline by means of a perfusion pump in male adrenalectomized SD rats. Drugs were injected intravenpusly by a syringe pump and their effect on pentagastrin-induced [10g/(kg·h), iv] gastric acid secretion was measured. The results were as follows: (1) The inhibitory effect of HA on gastric acid secretion was abolished by subdiaphragmatic vagotomy. (2) The inhibitory effect of HA on gastric acid secretion could be abolished by pretreatment with atropine [0.05 mg/(kg·100 min), iv]. (3) Pretreatment with somatostatin antagonist, cyclo[7-aminoheptanoyl-Phe-D-Trp-Lys-(Bzl)], [2～4 #mu#g/(kg·100 min), iv] could a1so block the inhihitory effect of HA on gastric acid secretion in a dose dependent manner.
Key words: Histamine;Third ventricle;Somatostatin antagonist;Gastric acid secretion;Atropine sulfate
张志方, 王竹立, 卢光启. 脑室注射组胺抑制大鼠胃酸分泌的外周机制[J]. 生理学报 1997; 49 (5): .
Zhang Zhifang, Wang Zhuli, Lu Guangqi. Centrally administrated histamine on gastric acid secertion. Acta Physiol Sin 1997; 49 (5): (in Chinese with English abstract).