ISSN 0371-0874, CN 31-1352/Q



胡巢凤, 王华东, 王达安, 王彦平, 李楚杰




关键词: 黑色素细胞刺激素; 白细胞介素-1; 腺苷环-磷酸; 下丘脑; 发热

Cui Hong

First Clinical Institute,China Medical University. Shenyang 110001,Liaoning, China


The effect of α- melanocyte-sitmulating hormone (α-MSH ) on IL-1βinduced feverand release of hypothalaminc cAMP was observed in the present work. The results showedthat α-MSH markedly suppressed febrile response (P<0.05) and decreased the cAMPcontent in hgpothalamus in response to icy injection of IL-1β (P<0.01).The cAMPcontent of the medium in which the hypothalamic was incubated for 40 min in thepresence of IL-1βwas significantly increased (P<0.01). However, this increase actioncould be prevented by a pretreatment with α-MSH. The results indicate that the inhibitoryeffect of α-MSH on the enhanced synthesis and release of cAMP in hypothalamus exposedto IL-1β mingt be one of the mechanisms of suppressing fever induced by IL-1β.

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胡巢凤, 王华东, 王达安, 王彦平, 李楚杰. α-黑色素细胞刺激素对白细胞介素-1β发热的解热机理研究[J]. 生理学报 1998; 50 (5): .

Cui Hong. . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).