ISSN 0371-0874, CN 31-1352/Q



陈爽, 范振中, 何瑞荣

河北医科大学基础医学研究所生理室. 石家庄 050017



关键词: 腺苷; 颈动脉窦; 窦神经传入放电

Cui Hong

First Clinical Institute,China Medical University. Shenyang 110001,Liaoning, China


The effects of adenosine (Ado) on the carotid baroreceptor were studied in 36anesthetized rats with isolated carotid sinus perfusion by recording the sinus nerve afferentactivity. The results obtained were as follows: (1)By perfusing the isolated carotid sinuswith 75 μmol/L Ado, the functional curve for inbeinus pressure(ISP)-integral of sinusnerve activity (ISNA) relation was shifted to the left and upward with peak slope (PS)increased from (18.75±0. 12)%/kPa to (22. 21 ±10. 11) %/kPa (P<0.001) and thepeak integral value (PIV) enhanced from (209. 83 ±2. 57) % to (239. 17 ±1 .75) % (P<0.001), while the threshold pressure (TP) and saturation pressure (SP) weresignificantly decreased from 8.57 ± 0.24 to 7. 15 ± 0.23 kPa (P<0.001) and from22.99 ± 0.34 to 21 .21 ± 0.43 kPa (P<0.01). By perfusing with high concentrations ofAdo (125 and 175 μnol/L), the curves for ISP-ISNA relation were shifted to the left andupward further and the changes of the functional parameters such as PS, TP and SP weredose-dependent.

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陈爽, 范振中, 何瑞荣. 腺苷易化大鼠颈动脉窦压力感受器的活动[J]. 生理学报 1998; 50 (5): .

Cui Hong. . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).