ISSN 0371-0874, CN 31-1352/Q



何昆仑, 郑秋甫, 牟善初, 李天昌, 庞永正, 唐朝枢

中国人民解放军总医院心肾科. 北京 100853;北京医科大学心血管基础研究所. 北京 100083



关键词: 自发性高血压大鼠; 丝裂素活化蛋白激酶; 血管紧张素Ⅱ; 心肌肥厚; 年龄


Mitogen-activated protein kinases (MAPKs) are thought to be critical components insignal transduction pathways in regulation of cell growth and differentiation. The purposeof the present investigation is to study possible involvement of MAPKs in the progress ofcardiac hypertrophy in spontaneously hypertensive rats (SHRs) and effects of age onAngiotensin Ⅱ (Ang Ⅱ), MAPK activity and cardiac hypertrophy. The animals weredivided into thee groups: 4 months old WKY rats (n=8), 4 month old SHRs (n=8)and 15 month old SHRs (n=6). Ratio of heart to body weight was measured. Ang Ⅱwas determined by RIA. MAPK activity in cardiac tissue was assayed by the "in-gel"myelin basic protein phosphorylation. The results show that in comparison with 4 monthold WKY rats, Ang Ⅱ in plasma and cardiac tissues were elevated (216.4%, P<0.01; 101.2%, P < 0.01 ) in 4 months old SHRs, while the MAPK activity wasincreased 107.0% (P < 0.01 ) with a parallel cardiac hypertrophy (P<0.01).

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何昆仑, 郑秋甫, 牟善初, 李天昌, 庞永正, 唐朝枢. 自发性高血压大鼠心肌肥厚和心肌MAPK、AngⅡ的关系[J]. 生理学报 1998; 50 (5): .

, , , , , . . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).