ISSN 0371-0874, CN 31-1352/Q



冯康, 李苏辉, 郭学勤

上海医科大学生理学教研室. 上海 200032



关键词: 室旁核; 血管升压素; 延髓头端腹外侧区; 防御性升压反应


Experments were carried out on male SD rats anesthetuzed with urethane (700 mg/kg) and chloralose (35 mg/kg). The results were as follws: (1) The pressor responsecould be elicited by electrical stimulation of dorsol part of midbrain periaqueductal gray(dPAG) for 5 s every 5 min. The pressor response for each series of dPAG stimulationwithin 50 min was constant. Tthis pressor response could be decreased by electrolyticcauterization Of paraventricular (PVN) area, but unaffected by electrolytic lesion offornix, anterior hypothalamic area, nucleas dorsomedialis hyopthalami and nucleusventromedicalis hypothalami (2) Microinjection of an AVP-V1 receptor antagonist(CH2)5 [Tyr (Me)2AVP] (each side 0. 1 nmol/0. 1 μl) into the bilateral rostalventrolateral medulla (rVLM) partially inhibited the pressor response induced by PVNstimulation or by microinjection of D, L-homocysteric acid (DLH) (0. 1 mol/0.2 μl) intothe PVN, but the mean artrtial pressure (MBP) and heart rate (HR) did not show anychange when an AVP-V1 recept

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冯康, 李苏辉, 郭学勤. 室旁核在刺激中脑防御反应区诱发防御性升压反应中的作用[J]. 生理学报 1998; 50 (5): .

, , . . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).