ISSN 0371-0874, CN 31-1352/Q



董京辉, 刘志伟, 黄少玲, 黄聿*

Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China



关键词: 维生素D; 维生素D受体; 肾素-血管紧张素系统; 氧化应激; 心血管功能


Cardiovascular benefits of vitamin D

Jinghui Dong, Chi Wai Lau, Siu Ling Wong, Yu Huang*



Vitamin D is essential for maintaining calcium and phosphate homeostasis, and vitamin D analogues have been prescribed to treat osteoporosis and hyperparathyroidism. Emerging evidence suggests that cardiovascular and chronic kidney diseases are closely associated with vitamin D deficiency resulting from either decreased sunshine exposure or inadequate intake. Vitamin D is through stimulating vitamin D receptor to form a transcriptional complex with cofactors to modulate approximately 3% gene transcription. For example, renin, matrix metalloprotease, and tumor necrosis factor-α are regulated by vitamin D. Both experimental and clinical studies support the health benefits of vitamin D in the cardiovascular system, and such benefits include protecting cardiac function, lowering blood pressure, improving endothelial function, inhibiting oxidative stress, and reducing the activity of renin-angiotensin system. This article will briefly review the cardiovascular benefits of vitamin D and its bioactive analogues and discuss the novel cellular and molecular mechanisms accounting for cardiovascular protection.

Key words: vitamin D; vitamin D receptor; renin-angiotensin system; oxidative stress; cardiovascular function

收稿日期:  录用日期:

通讯作者:黄聿  E-mail:


董京辉, 刘志伟, 黄少玲, 黄聿. 维生素D对心血管系统保护作用的研究进展[J]. 生理学报 2014; 66 (1): 30-36.

Jinghui Dong, Chi Wai Lau, Siu Ling Wong, Yu Huang. Cardiovascular benefits of vitamin D. Acta Physiol Sin 2014; 66 (1): 30-36 (in Chinese with English abstract).