ISSN 0371-0874, CN 31-1352/Q



胡燎燎, 向晟, 郑莉萍*

南昌大学江西医学院医学实验教学中心,南昌 330031



关键词: 原始卵泡; 静息状态; 信号分子


[Signaling molecules and pathways involved in maintaining the quiescence of primordial follicles.] [Article in Chinese]

HU Liao-liao, XIANG Cheng, ZHENG Li-Ping*

Medical Experimental Teaching Department, Jiangxi Medical College of Nanchang University, Nanchang 330031, China


Clarifying the regulation mechanisms of primordial follicle initiation is crucial for the prevention of premature ovarian failure and treatment of female infertility. Reproductive lifespan in female mammals is related to the size of primordial follicles pool which relies on the balance between activated and quiescent primordial follicles, therefore, the molecular mechanisms underlying recruiting quiescence primordial follicles have become a hotspot recently. Multiple studies have shown that genetic mutations, local ovarian autocrine and paracrine factors, proto-oncogene andtumor-suppressor genes involved in the maintenance of balance between quiescence and activated primordial follicles. In the present review, we summarize the important signaling molecules and pathways that maintain the quiescence of primordial follicles to provide insight for prolonging reproductive lifespan.

Key words: primordial follicles; quiescent state; signaling molecules

收稿日期:2014-08-07  录用日期:2014-10-13

通讯作者:郑莉萍  E-mail:


胡燎燎, 向晟, 郑莉萍. 维持原始卵泡静息状态的相关信号分子及通路[J]. 生理学报 2015; 67 (1): 59-64.

HU Liao-liao, XIANG Cheng, ZHENG Li-Ping. [Signaling molecules and pathways involved in maintaining the quiescence of primordial follicles.] [Article in Chinese]. Acta Physiol Sin 2015; 67 (1): 59-64 (in Chinese with English abstract).