ISSN 0371-0874, CN 31-1352/Q



谭建新, 王亚君, 朱喜科*

中国医科大学附属盛京医院实验研究中心,沈阳 110004



关键词: 胸腺增龄性萎缩; 再生 ; 性激素 ; 细胞因子 ; 转录因子 ; 细胞移植 ; microRNA


Progresses in therapeutic strategies for thymic rejuvenation

TAN Jian-Xin, WANG Ya-Jun, ZHU Xi-Ke**

Research Center, Shengjing Hospital of China Medical University, Shenyang 110004, China


The thymus is a vital primary lymphoid organ that provides unique microenvironments for the proliferation, differentiation, and maturation of T cells. With advancing age, however, the thymus gradually undergoes age-related involution and reduction in immune function, which are characterized by decrease in tissue size, cellularity, and naïve T cell output. This dynamic process leads to the reduced efficacy of the immune system with age and contributes to the increased susceptibility to infection, autoimmune disease, and cancer. In addition, bone marrow transplantation, radio-chemotherapy and virus infection also impair the thymus and give rise to decline in immune function. Therefore, understanding the molecular mechanisms involved in age-related thymic involution and development of novel therapeutic strategies for thymic rejuvenation have gained considerable interests in recent years. This review emphasizes thymic microenvironments and thymocyte-stromal cell interactions and summarizes our current knowledge about thymic rejuvenation in terms of sex steroid, cytokines, growth factors, hormones, transcription factors, cell graft, and microRNAs. At the end of each discussion, we also highlight unanswered issues and describe possible future research directions.

Key words: thymic age-related involution; rejuvenation ; sex steroid ; cytokines ; transcription factors ; cell graft ; microRNA

收稿日期:2015-08-03  录用日期:2015-11-25

通讯作者:朱喜科  E-mail:


谭建新, 王亚君, 朱喜科. 胸腺再生的研究进展与策略[J]. 生理学报 2016; 68 (1): 75-86.

TAN Jian-Xin, WANG Ya-Jun, ZHU Xi-Ke*. Progresses in therapeutic strategies for thymic rejuvenation. Acta Physiol Sin 2016; 68 (1): 75-86 (in Chinese with English abstract).