ISSN 0371-0874, CN 31-1352/Q



厉永强, 付苏, 王来, 刘彬, 石贞玉*, 邓锦波*

河南大学护理学院神经生物研究所,开封 475004



关键词: 自噬; 缺氧缺血; 氧化应激; 细胞凋亡


[Autophagy and hypoxic ischemic brain injuries.] [Article in Chinese]

LI Yong-Qiang, FU Su, WANG Lai, LIU Bin, SHI Zhen-Yu*, DENG Jin-Bo*

Institute of Neurobiology, Nursing College, Henan University, Kaifeng 475004, China


Autophagy is a highly evolutionarily conserved physiological mechanism of organism, including several stages such as autophagosomes formation, the fusion of lysosomes and autophagosomes, and autophagosomes degradation. In physiological conditions, autophagy is responsible for clearing the spoiled organelles and long-lived proteins to maintain the homeostasis of cells and organism. Meanwhile, autophagy is also involved in the formation and development of diseases, but the mechanism has not been confirmed yet. The relationship between autophagy and hypoxic ischemic brain injuries represented by stroke is a research hotpot in recent years, but there is no clear conclusion about autophagy’s role and mechanism in hypoxic ischemic brain injuries. We reviewed the activation, function and mechanism of autophagy in hypoxic ischemic brain injuries, in order to provide some perspectives on these researches.

Key words: autophagy; hypoxia and ischemia; oxidative stress response; apoptosis

收稿日期:2016-11-24  录用日期:2017-03-14

通讯作者:石贞玉,邓锦波  E-mail:,


厉永强, 付苏, 王来, 刘彬, 石贞玉, 邓锦波. 自噬与缺氧缺血性脑损伤[J]. 生理学报 2017; 69 (3): 316-324.

LI Yong-Qiang, FU Su, WANG Lai, LIU Bin, SHI Zhen-Yu, DENG Jin-Bo. [Autophagy and hypoxic ischemic brain injuries.] [Article in Chinese]. Acta Physiol Sin 2017; 69 (3): 316-324 (in Chinese with English abstract).