ISSN 0371-0874, CN 31-1352/Q



李玲, 文娟, 庹勤慧, 廖端芳

南华大学药物药理研究所,衡阳 421001;湖南中医药大学药学部中医诊断学系,长沙 410208


死亡结构域相关蛋白(death domain-associated protein, DAXX)是一个多功能的核蛋白,广泛分布于核仁、核质、染色质、早幼粒细胞白血病蛋白核体(PML-NBs)和胞浆等亚细胞区域,对细胞的转录调控、凋亡及细胞周期等生物学活动发挥重要作用。SUMO化修饰(small ubiquitin-like modification)是一种重要的、高度保守的翻译后生物学修饰,大量文献显示SUMO化修饰对DAXX的亚细胞定位及功能的调节具有重要意义。本文对此方面的研究进展做一综述。

关键词: 小泛素相关修饰蛋白; 死亡结构域相关蛋白; 亚细胞定位; 小泛素化


[Effects of SUMOylation on the subcellular localization and function of DAXX.] [Article in Chinese]

Li Ling, WEN Juan, TUO Qin-Hui, LIAO Duan-Fang

Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China; School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China


Death domain-associated protein (DAXX) as a multifunctional nuclear protein widely resides in nucleolus, nucleoplasm, chromatin, promyelocytic leukaemia nuclear bodies (PML-NBs) and cytoplasm. It plays significant roles in transcriptional regulation, apoptosis, cell cycle and other biological activities. Small ubiquitin-like modifier (SUMO) is required for SUMOylation which is a highly conserved post-translational modification in a wide variety of cellular processes. Numerous studies demonstrated that SUMOylation has a great effect on the subcellular localization and functional regulation of DAXX. This review will provide a summary for SUMOylation of DAXX.

Key words: small ubiquitin-like modifier; death domain-associated protein; subcellular localization; SUMOylation

收稿日期:2012-05-10  录用日期:2012-08-20

通讯作者:庹勤慧  E-mail:


李玲, 文娟, 庹勤慧, 廖端芳. SUMO化对DAXX亚细胞定位与功能影响的研究进展[J]. 生理学报 2013; 65 (1): 89-95.

Li Ling, WEN Juan, TUO Qin-Hui, LIAO Duan-Fang. [Effects of SUMOylation on the subcellular localization and function of DAXX.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (1): 89-95 (in Chinese with English abstract).