ISSN 0371-0874, CN 31-1352/Q



JohnCLonghurst*, StephanieCTjen-A-Looi

加州大学欧文分校医学院,生理、生物物理和药理学院;Susan Samueli综合医学研究中心,欧文 CA 92697,美国



关键词: 交感神经系统; 转录调节 ; 肾素 ; 去甲肾上腺素 ; 高血压


Evidence-based blood pressure reducing actions of electroacupuncture: mechanisms and clinical application

John C Longhurst*, Stephanie C Tjen-A-Looi

Susan Samueli Center for Integrative Medicine; Departments of Medicine, Physiology and Biophysics and Pharmacology, University of California, Irvine, Irvine, CA 92697, USA


Hypertension is a serious world-wide health problem as it increases cardiovascular atherosclerotic risk, stroke and attending morbidity and mortality.  Both systolic and diastolic blood pressures and particularly systolic pressure increase with aging.  The downsides from pharmacological therapy have led to consideration of additional treatments, including acupuncture, which evokes endogenous neural-hormonal systems to lower blood pressure. Using basic science studies to guide clinical approaches to research, it is apparent that low frequency, low intensity electroacupuncture reduces sympathetic outflow in approximately 70% of patients with mild to moderate hypertension who are off antihypertensive drugs. Systolic and, to a lesser extent, diastolic arterial blood pressures can be lowered over two to four weeks for prolonged periods, lasting as long as one month, after cessation of an eight weeks of once weekly stimulation. Many questions about long-term therapy, treatment of resistant patients and efficacy in patients on medication remain to be studied. Current data, however, suggest that there may be a role of acupuncture in treatment of hypertension.  

Key words: sympathetic; transcriptional regulation ; renin ; norepinephrine ; hypertension

收稿日期:2017-02-23  录用日期:2017-06-02

通讯作者:JohnCLonghurst  E-mail:

DOI: 10.13294/j.aps.2017.0035


JohnCLonghurst, StephanieCTjen-A-Looi. 电针降压作用的证据、机制和临床应用[J]. 生理学报 2017; 69 (5): 587-597.

John C Longhurst, Stephanie C Tjen-A-Looi. Evidence-based blood pressure reducing actions of electroacupuncture: mechanisms and clinical application. Acta Physiol Sin 2017; 69 (5): 587-597