ISSN 0371-0874, CN 31-1352/Q



应慧敏1, 张焱2,*

1杭州市西溪医院内分泌科,杭州 310023;2深圳大学生命与海洋科学学院,深圳 518071



关键词: 离子组; 微量元素; 复杂疾病; 生物信息学; 网络


Progress on ionomics of complex diseases

YING Hui-Min1, ZHANG Yan2,*

1Department of Endocrinology, Hangzhou Xixi Hospital, Hangzhou 310023, China;2College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518071, China


Ionomics is a new multidisciplinary scientific field for investigating the composition and distribution of all chemical elements in specific biological systems as well as their variations under different physiological and pathological conditions. It combines both high-throughput techniques for element profile measurement and bioinformatic methods, which provides new ideas for obtaining a systems-level understanding of biological utilization and functions of these elements. More and more results of researches suggest that ionomics has important theoretical and practical values in etiological study, early diagnosis and screening, and therapeutic strategy selection for complex diseases. In this review, we focus on current advances in the ionomic studies of several complex diseases, which may help further understand the effect and important properties of individual elements, as well as their dynamic ionomic networks in the occurrence and development of diseases.

Key words: ionome; ionomics; trace element; complex disease; network

收稿日期:2017-12-15  录用日期:2018-05-03

通讯作者:张焱  E-mail:

DOI: 10.13294/j.aps.2018.0036


应慧敏, 张焱. 复杂疾病的离子组学研究进展[J]. 生理学报 2018; 70 (4): 413-423.

YING Hui-Min, ZHANG Yan. Progress on ionomics of complex diseases. Acta Physiol Sin 2018; 70 (4): 413-423 (in Chinese with English abstract).