ISSN 0371-0874, CN 31-1352/Q



成海鹏1, 冯丹丹1, 岳少杰2, 罗自强1,*

1中南大学湘雅医学院生理学系,长沙 410078;2中南大学湘雅医院儿科,长沙 410078



关键词: 铁死亡; 代谢网络; 急性肺损伤; 慢性阻塞性肺疾病; 肺纤维化


The metabolic networks of ferroptosis and links to lung diseases

CHENG Hai-Peng1, FENG Dan-Dan1, YUE Shao-Jie2, LUO Zi-Qiang1,*

1Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China;2Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410078, China


Ferroptosis is a newly discovered non-apoptotic form of regulated cell death driven by iron-dependent lipid peroxidation. The present studies have shown that many metabolic processes and homeostasis are affected by ferroptosis. It is related to many lung diseases, including acute lung injury, chronic obstructive pulmonary disease and pulmonary fibrosis, etc. Currently, the research on ferroptosis is still in its infancy. Previous studies have confirmed that ferroptosis is regulated by a variety of genes, and the mechanism is complex, mainly involving iron homeostasis and lipid peroxidation metabolism. This review summarizes some regulation networks of metabolic processes associated with ferroptosis and discusses the roles of ferroptosis in the pathophysiological progression of many lung diseases. We expected to provide new ideas and references for the treatment of these diseases.

Key words: ferroptosis; metabolic networks; acute lung injury; chronic obstructive pulmonary disease; pulmonary fibrosis

收稿日期:2020-05-21  录用日期:2020-08-17

通讯作者:罗自强  E-mail:

DOI: 10.13294/j.aps.2020.0069


成海鹏, 冯丹丹, 岳少杰, 罗自强. 铁死亡中的代谢调控网络及其与肺相关疾病的联系[J]. 生理学报 2020; 72 (5): 566-574.

CHENG Hai-Peng, FENG Dan-Dan, YUE Shao-Jie, LUO Zi-Qiang. The metabolic networks of ferroptosis and links to lung diseases. Acta Physiol Sin 2020; 72 (5): 566-574 (in Chinese with English abstract).