ISSN 0371-0874, CN 31-1352/Q



陈海霞, 吴燕萍, 李雯, 沈华浩, 陈志华*

浙江省呼吸疾病诊治及研究重点实验室,浙江大学医学院附属第二医院呼吸与危重症医学科,杭州 310009



关键词: 铁死亡; 呼吸系统疾病; 铁死亡诱导剂; 脂质过氧化物


Ferroptosis in respiratory diseases

CHEN Hai-Xia, WU Yan-Ping, LI Wen, SHEN Hua-Hao, CHEN Zhi-Hua*

Key Laboratory of Respiratory Diseases of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China


Ferroptosis is a novel form of regulated cell death which is dependent on iron and reactive oxygen species (ROS) and associated with the accumulation of lipid peroxides. It is obviously different from other cell death types in terms of morphology, biochemistry, genetics, etc. Also, it is related to the production of iron catalyzed lipid peroxides which is triggered by non-enzymatic or enzymatic reactions. Ferroptosis has been proved to be involved in hematological diseases, cardio-cerebrovascular diseases, liver and kidney diseases. This paper will review the definition, mechanism, inducers of ferroptosis, as well as the function of ferroptosis   in respiratory system. We expect to present a new concept for respiratory research and suggest potential targets for clinical prevention and treatment of respiratory diseases.

Key words: ferroptosis; respiratory diseases; ferroptosis inducers; lipid peroxides

收稿日期:2020-04-29  录用日期:2020-08-18

通讯作者:陈志华  E-mail:

DOI: 10.13294/j.aps.2020.0064


陈海霞, 吴燕萍, 李雯, 沈华浩, 陈志华. 铁死亡在呼吸系统疾病中的研究进展及应用[J]. 生理学报 2020; 72 (5): 575-585.

CHEN Hai-Xia, WU Yan-Ping, LI Wen, SHEN Hua-Hao, CHEN Zhi-Hua. Ferroptosis in respiratory diseases. Acta Physiol Sin 2020; 72 (5): 575-585 (in Chinese with English abstract).