李博文, 冯丽丽, 田振军*
胰岛素样生长因子-1 (insulin-like growth factor-1, IGF-1)是分子结构与胰岛素类似的多肽类物质。IGF-1在组织生长发育、细胞代谢、增殖、分化和凋亡中发挥关键作用。IGF-1主要由肝脏分泌，其分泌量占总体的75%，剩余25%由骨骼肌、心、肾和脾等器官分泌。IGF-1可靶向心脏、血管、肝脏、骨和骨骼肌等多种组织和器官发挥作用。IGF-1在多种代谢性疾病的防治中发挥重要作用。不同类型的运动对不同器官中IGF-1水平的影响不同。本文对IGF-1防治代谢性疾病及其在运动领域的研究进展进行综述。
Research progress of the role of IGF-1 in metabolic diseases and the effect of exercise intervention
LI Bo-Wen, FENG Li-Li, TIAN Zhen-Jun*
Department of Sports and Cardiovascular Health, Institute of Sports Biology, College of Physical Education, Shaanxi Normal University, Xi’an 710119, China
Insulin-like growth factor-1 (IGF-1) is a peptide with a similar molecular structure to insulin. IGF-1 plays a key role in tissue growth and development, as well as cell metabolism, proliferation, differentiation and apoptosis. Liver is the main source of IGF-1, with the production of IGF-1 up to 75% of the total in the whole body, while the remaining 25% are secreted by skeletal muscles, heart, kidney, spleen and other organs. Target organs of IGF-1 include heart, blood vessels, liver, bone and skeletal muscles. It has been well documented that IGF-1 plays an important role in the prevention and treatment of metabolic diseases. Different types of exercise have different effects on IGF-1 expression with organ differences. In this article, we reviewed the preventive and therapeutic effects of IGF-1 on metabolic diseases and IGF-1-mediated exercise-induced benefits.
通讯作者：田振军 E-mail: email@example.com
李博文, 冯丽丽, 田振军. 胰岛素样生长因子-1与代谢性疾病及运动干预的研究进展[J]. 生理学报 2021; 73 (2): 342-352.
LI Bo-Wen, FENG Li-Li, TIAN Zhen-Jun. Research progress of the role of IGF-1 in metabolic diseases and the effect of exercise intervention. Acta Physiol Sin 2021; 73 (2): 342-352 (in Chinese with English abstract).