ISSN 0371-0874, CN 31-1352/Q



张子叶1, 向导2, 罗贝贝1,*

1上海体育学院运动科学学院,上海 200438;2海军军医大学海军特色医学中心,上海 200433



关键词: 胃肠类器官; 肝脏类器官; 微环境; 运动; 低氧


Organoids derived from the digestive system and their perspective applications in exercise physiology

ZHANG Zi-Ye1, XIANG Dao2, LUO Bei-Bei1,*

1School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China;2Naval Research Institute, Naval Medical University, Shanghai 200433, China


Organoid, formed from organ-specific cells, is a group of self-renewal and self-organizing cells growing in a 3-dimensional structure. With the recent progress on microenvironment regulation, stem cell differentiation and organ development, organoids have been constructed and used as promising tools for a wide range of multidisciplinary biomedical applications. Exercise disrupts the internal environment homeostasis, which brings a series of physiological alterations to the digestive system. The current animal or human models are necessary, but not sufficient to monitor the fluctuating microenvironment of gastrointestinal epithelial cells or hepatocytes during exercise. This review described the construction and application of digestive system organoids, as well as the effect of exercise on the microenvironment of intestinal epithelial cells and hepatocytes. The perspective applications of digestive system organoids in exercise physiology were also stated. Using organoid technologies, the possible mechanisms of the exercise- induced dynamic physiological changes would be explored in a new dimension.

Key words: gastrointestinal organoid; hepatic organoid; microenvironment; exercise; hypoxia

收稿日期:2020-08-11  录用日期:2021-01-25

通讯作者:罗贝贝  E-mail:

DOI: 10.13294/j.aps.2021.0017


张子叶, 向导, 罗贝贝. 消化系统类器官及其在运动生理学研究中的应用前景[J]. 生理学报 2021; 73 (3): 509-517.

ZHANG Zi-Ye, XIANG Dao, LUO Bei-Bei. Organoids derived from the digestive system and their perspective applications in exercise physiology. Acta Physiol Sin 2021; 73 (3): 509-517 (in Chinese with English abstract).