ISSN 0371-0874, CN 31-1352/Q



刘红1, 袁一旻1, 秦尚尧1, 刘韬2, 苏志达1,*

1海军军医大学神经生物学教研室,分子神经生物学教育部重点实验室,上海 200433;2复旦大学附属中山医院神经内科,上海 200032



关键词: NG2胶质细胞; 生物学特性; 功能; 中枢神经损伤和疾病; 治疗应用


Biological characteristics and functions of NG2-glia

LIU Hong1, YUAN Yi-Min1, QIN Shang-Yao1, LIU Tao2, SU Zhi-Da1,*

1Department of Neurobiology and Key Laboratory of Molecular Neurobiology of Ministry of Education, Navy Military Medical University, Shanghai 200433, China;2Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China


NG2-glia are a major type of glial cells that are widely distributed in the central nervous system (CNS). Under physiological conditions, they mainly differentiate into oligodendrocytes and contribute to the myelination of axons, so they are generally called oligodendrocyte progenitor cells. Emerging evidence suggests that NG2-glia not only act as the precursors of oligodendrocytes but also possess many other biological properties and functions. For example, NG2-glia can form synapse with neurons and participate in energy metabolism and immune regulation. Under pathological conditions, NG2-glia can also differentiate into astrocytes, Schwann cells and even neurons, which are involved in CNS injury and repair. Therefore, a deeper understanding of the biological characteristics and functions of NG2-glia under physiological and pathological conditions will be helpful for the treatment of CNS injury and disease. This article reviews the recent advances in the biological characteristics and functions of NG2-glia.

Key words: NG2-glia; biological characteristics; functions; CNS injury and disease; therapeutic application

收稿日期:2020-11-25  录用日期:2021-02-26

通讯作者:苏志达  E-mail:


刘红, 袁一旻, 秦尚尧, 刘韬, 苏志达. NG2胶质细胞的生物学特性和功能[J]. 生理学报 2021; 73 (6): 940-952.

LIU Hong, YUAN Yi-Min, QIN Shang-Yao, LIU Tao, SU Zhi-Da. Biological characteristics and functions of NG2-glia. Acta Physiol Sin 2021; 73 (6): 940-952 (in Chinese with English abstract).